Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Tadeusz F. Molinski"'
Small molecule in situ resin capture provides a compound first approach to natural product discovery
Autor:
Alexander Bogdanov, Mariam N. Salib, Alexander B. Chase, Heinz Hammerlindl, Mitchell N. Muskat, Stephanie Luedtke, Elany Barbosa da Silva, Anthony J. O’Donoghue, Lani F. Wu, Steven J. Altschuler, Tadeusz F. Molinski, Paul R. Jensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Culture-based microbial natural product discovery strategies fail to realize the extraordinary biosynthetic potential detected across earth’s microbiomes. Here we introduce Small Molecule In situ Resin Capture (SMIRC), a culture-independen
Externí odkaz:
https://doaj.org/article/7ba9d42708bb45c1a8547a7ae7e75601
Autor:
Jehad Almaliti, Momen Alhindy, Michael C. Yoon, Vivian Hook, Tadeusz F. Molinski, Anthony J. O’Donoghue, William H. Gerwick
Publikováno v:
ACS Omega, Vol 9, Iss 3, Pp 3997-4003 (2024)
Externí odkaz:
https://doaj.org/article/c37339e22da74790a82befae2753392d
Publikováno v:
Marine Drugs, Vol 21, Iss 8, p 446 (2023)
Petrosamine (1)—a colored pyridoacridine alkaloid from the Belizean sponge, Petrosia sp., that is also a potent inhibitor of acetylcholine esterase (AChE)—was investigated by spectroscopic and computational methods. Analysis of the petrosamine-fr
Externí odkaz:
https://doaj.org/article/15180bbcc43c4836958af6b34e266ac4
Autor:
Xiaxia Di, Ingibjorg Hardardottir, Jona Freysdottir, Dongdong Wang, Kirk R. Gustafson, Sesselja Omarsdottir, Tadeusz F. Molinski
Publikováno v:
Molecules, Vol 28, Iss 7, p 2937 (2023)
Geobarrettin D (1), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including 1H-15N HSQC, 1H-15N HMBC spectra), as well as HRESIMS data.
Externí odkaz:
https://doaj.org/article/c3be15501c57479284de7b26206564c0
Autor:
Tatyana N. Makarieva, Natalia V. Ivanchina, Pavel S. Dmitrenok, Alla G. Guzii, Valentin A. Stonik, Doralyn S. Dalisay, Tadeusz F. Molinski
Publikováno v:
Marine Drugs, Vol 19, Iss 11, p 635 (2021)
Oceanalin B (1), an α,ω-bipolar natural product belonging to a rare family of sphingoid tetrahydoisoquinoline β-glycosides, was isolated from the EtOH extract of the lyophilized marine sponge Oceanapia sp. as the second member of the series after
Externí odkaz:
https://doaj.org/article/d3086b6f6eec4f80aa73bd3c04bba392
Autor:
Makoto N. Masuno, Tadeusz F. Molinski
Publikováno v:
ACS Omega, Vol 3, Iss 7, Pp 7771-7775 (2018)
Externí odkaz:
https://doaj.org/article/e4ad32b8cd3a4c43885396e7ef09598e
Publikováno v:
Marine Drugs, Vol 19, Iss 3, p 126 (2021)
Oceanapiside (OPS), a marine natural product with a novel bifunctional sphingolipid structure, is fungicidal against fluconazole-resistant Candida glabrata at 10 μg/mL (15.4 μM). The fungicidal effect was observed at 3 to 4 h after exposure to cell
Externí odkaz:
https://doaj.org/article/4e6f5ff42a92464896fcc14d96bfb95a
Publikováno v:
Marine Drugs, Vol 17, Iss 2, p 102 (2019)
Bengazoles A–G from the marine sponge Jaspis sp. exhibit potent in vitro antifungal activity against Candida spp. and other pathogenic fungi. The mechanism of action (MOA) of bengazole A was explored in Candida albicans under both liquid culture an
Externí odkaz:
https://doaj.org/article/abc22c76af36477497f4e8819ce34c92
Publikováno v:
Molecules, Vol 24, Iss 1, p 90 (2018)
Sample configurations of distaminolyne A (1a); isolated from the ascidians Pseudodistoma opacum and P. cereum, and collected at different sites in New Zealand, were investigated by two methods: Exciton coupled electronic circular dichroism (EC ECD) o
Externí odkaz:
https://doaj.org/article/392714bf02804e82943e44937f2c52ab
Autor:
Xiaxia Di, Caroline Rouger, Ingibjorg Hardardottir, Jona Freysdottir, Tadeusz F. Molinski, Deniz Tasdemir, Sesselja Omarsdottir
Publikováno v:
Marine Drugs, Vol 16, Iss 11, p 437 (2018)
An UPLC-qTOF-MS-based dereplication study led to the targeted isolation of seven bromoindole alkaloids from the sub-Arctic sponge Geodia barretti. This includes three new metabolites, namely geobarrettin A–C (1–3) and four known compounds, barett
Externí odkaz:
https://doaj.org/article/adf502693d864dd4a9e7590f0092c70d