Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tade Souaiaia"'
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology.
BACKGROUND: Sphingomyelin (SM) and cholesterol are 2 key lipid partners on cell membranes and on lipoproteins. Many studies have indicated the influence of cholesterol on SM metabolism. This study examined the influence of SM biosynthesis on choleste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e355a6096de12c8cb20df4e3531f8d0
https://doi.org/10.1161/atvbaha.123.319031
https://doi.org/10.1161/atvbaha.123.319031
The use of siblings to infer the factors influencing complex traits has been a cornerstone of quantitative genetics. Here we utilise siblings for a novel application: the identification of genetic architecture, specifically that in individuals with e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f6b3d7bb571f420dc6b4c60851b3aa7
https://doi.org/10.1101/2023.02.19.529159
https://doi.org/10.1101/2023.02.19.529159
Autor:
Clive Hoggart, Shing Wan Choi, Judit García-González, Tade Souaiaia, Michael Preuss, Paul O’Reilly
Publikováno v:
bioRxiv
Polygenic Risk Scores (PRS) have huge potential to contribute to biomedical research and to a future of precision medicine, but to date their calculation relies largely on Europeanancestry GWAS data. This global bias makes most PRS substantially less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2435a6006d818f7ac0770df69460d6b3
https://doi.org/10.1101/2023.02.17.528938
https://doi.org/10.1101/2023.02.17.528938
Autor:
Tade Souaiaia, Paul O'Reilly
Publikováno v:
European Neuropsychopharmacology. 63:e155-e156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14689c2c56dd24e908dd0836e239a456
https://doi.org/10.1016/j.euroneuro.2022.07.285
https://doi.org/10.1016/j.euroneuro.2022.07.285
Autor:
Delores A. French, Jonathan A. Oler, Andrew S. Fox, Matthew R Rabska, Jae Mun ‘Hugo’ Kim, Andrew L. Alexander, Ned H. Kalin, Miles Olsen, Joseph D. Nguyen, Patrick H. Roseboom, Rothem Kovner, Eva M. Fekete, Marissa K. Riedel, Walter F. Block, Tade Souaiaia, James A. Knowles, Ethan K. Brodsky
Publikováno v:
Biological psychiatry, vol 86, iss 12
Biol Psychiatry
Biol Psychiatry
Background An early-life anxious temperament (AT) is a risk factor for the development of anxiety, depression, and comorbid substance abuse. We validated a nonhuman primate model of early-life AT and identified the dorsal amygdala as a core component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf925fc80d30c70a15e48f77320427d
https://doi.org/10.1016/j.biopsych.2019.06.022
https://doi.org/10.1016/j.biopsych.2019.06.022
Autor:
Margaux Kenwood, Tade Souaiaia, Rothem Kovner, Andrew Fox, Delores French, Jonathan Oler, Patrick Roseboom, Marissa Riedel, Ned Kalin
Publikováno v:
Biological Psychiatry. 91:S132
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dffa302d9c607b73fea4ee84b99c77fb
https://doi.org/10.1016/j.biopsych.2022.02.345
https://doi.org/10.1016/j.biopsych.2022.02.345
Autor:
Andrew S. Fox, Tade Souaiaia, Rothem Kovner, Marissa K. Riedel, Ned H. Kalin, Jonathan A. Oler, Julie L. Fudge, Patrick H. Roseboom, Delores A. French, James A. Knowles, Cooper. E. Goss, Eva M. Fekete
Publikováno v:
Biological psychiatry, vol 88, iss 8
Biol Psychiatry
Biol Psychiatry
BackgroundChildren exhibiting extreme anxious temperament (AT) are at an increased risk for developing anxiety and depression. Our previous mechanistic and neuroimaging work in young rhesus monkeys linked the central nucleus of the amygdala to AT and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18708a8a682ef16efd57da7bafd0f7a5
https://escholarship.org/uc/item/63d5w7zt
https://escholarship.org/uc/item/63d5w7zt
Autor:
Matthew E. Thornton, Jae Mun ‘Hugo’ Kim, Robert H. Chow, Victoria Wolseley, Adrian Camarena, Oleg V. Evgrafov, Brendan H. Grubbs, Ming-Yi Lin, Christopher P Walker, Tade Souaiaia, James A. Knowles
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Most single cell RNA sequencing protocols start with single cells dispersed from intact tissue. High-throughput processing of the separated cells is enabled using microfluidics platforms. However, dissociation of tissue results in loss of information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e03f82a48f91afe08e81cb4ed26474
https://doi.org/10.1038/s41598-020-58715-y
https://doi.org/10.1038/s41598-020-58715-y
Autor:
James A. Knowles, Oleg V. Evgrafov, Siwei Zhang, Tade Souaiaia, Hanwen Zhang, Abolfazl Doostparast Torshizi, Jubao Duan, Kai Wang, Chris Armoskus, Marc P. Forrest
Publikováno v:
Science Advances
TCF4 acts as a master regulator affecting expression of other genes, which may contribute to the development of schizophrenia.
Applying tissue-specific deconvolution of transcriptional networks to identify their master regulators (MRs) in neurop
Applying tissue-specific deconvolution of transcriptional networks to identify their master regulators (MRs) in neurop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8292c1082379c6096395726cc9ba0e9
http://europepmc.org/articles/PMC6739105
http://europepmc.org/articles/PMC6739105
Autor:
Carlos N. Pato, Valeria N. Spitsyna, Edder Lopez Duarte, Chris Armoskus, Bozena Wrobel, Janet L. Sobell, Michele T. Pato, Kai Wang, Oleg V. Evgrafov, Tade Souaiaia, Christopher P Walker, George M. Simpson, Jonathan Weitz, Helena Medeiros, Jennifer Herstein, James A. Knowles, Adrian Camarena, Joseph D. Nguyen, Jae Mun ‘Hugo’ Kim
Publikováno v:
Biological psychiatry. 88(3)
Genome-wide association studies of schizophrenia have demonstrated that variations in noncoding regions are responsible for most of the common variation heritability of the disease. It is hypothesized that these risk variants alter gene expression. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe87430f5997668417b7062a2c8d6e8
https://pubmed.ncbi.nlm.nih.gov/32143829
https://pubmed.ncbi.nlm.nih.gov/32143829