Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist.

Autor: Clarke E; Neuroscience Drug Discovery Unit, Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College, London SE1 1UL, UK., Jarvis CI; Neuroscience Drug Discovery Unit, Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College, London SE1 1UL, UK., Goncalves MB; Neuroscience Drug Discovery Unit, Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College, London SE1 1UL, UK., Kalindjian SB; Neuroscience Drug Discovery Unit, Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College, London SE1 1UL, UK., Adams DR; Sygnature Discovery Limited, Biocity, Pennyfoot Street, Nottingham NG1 1GF, UK., Brown JT; Sygnature Discovery Limited, Biocity, Pennyfoot Street, Nottingham NG1 1GF, UK., Shiers JJ; Sygnature Discovery Limited, Biocity, Pennyfoot Street, Nottingham NG1 1GF, UK., Taddei DMA; Sygnature Discovery Limited, Biocity, Pennyfoot Street, Nottingham NG1 1GF, UK., Ravier E; Sygnature Discovery Limited, Biocity, Pennyfoot Street, Nottingham NG1 1GF, UK., Barlow S; Sygnature Discovery Limited, Biocity, Pennyfoot Street, Nottingham NG1 1GF, UK., Miller I; Sygnature Discovery Limited, Biocity, Pennyfoot Street, Nottingham NG1 1GF, UK., Smith V; Sygnature Discovery Limited, Biocity, Pennyfoot Street, Nottingham NG1 1GF, UK., Borthwick AD; DrugMolDesign, 15 Temple Grove, London NW11 7UA, UK. Electronic address: alan.d.borthwick@drugmoldesign.com., Corcoran JPT; Neuroscience Drug Discovery Unit, Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College, London SE1 1UL, UK.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 Feb 15; Vol. 26 (4), pp. 798-814. Date of Electronic Publication: 2017 Dec 09.