Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Tadayoshi Karasawa"'
Autor:
Naoya Yamada, Tadayoshi Karasawa, Junya Ito, Daisuke Yamamuro, Kazushi Morimoto, Toshitaka Nakamura, Takanori Komada, Chintogtokh Baatarjav, Yuma Saimoto, Yuka Jinnouchi, Kazuhisa Watanabe, Kouichi Miura, Naoya Yahagi, Kiyotaka Nakagawa, Takayoshi Matsumura, Ken-ichi Yamada, Shun Ishibashi, Naohiro Sata, Marcus Conrad, Masafumi Takahashi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, the organ-specific regulation mechanism is poorly understood. Here, we demonstrate 7-dehydrocholesterol reductase (DHCR7), the ter
Externí odkaz:
https://doaj.org/article/cf67912edd5e4955a7683d3553f31fd5
Autor:
Takayoshi Matsumura, Haruhito Totani, Yoshitaka Gunji, Masahiro Fukuda, Rui Yokomori, Jianwen Deng, Malini Rethnam, Chong Yang, Tze King Tan, Tadayoshi Karasawa, Kazuomi Kario, Masafumi Takahashi, Motomi Osato, Takaomi Sanda, Toshio Suda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The transcription factor MYB has been shown to regulate haematopoietic stem cells but there could be lineage specific enhancers. Here, using lineage tracing and single cell sequencing the authors characterise a Myb −68 enhancer that regulates the d
Externí odkaz:
https://doaj.org/article/f7b34ab06eff47b1947cf8949cde1d29
Autor:
Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Emi Aizawa, Yoshiko Mizushina, Sachiko Watanabe, Chintogtokh Baatarjav, Takayoshi Matsumura, Masafumi Takahashi
Publikováno v:
eLife, Vol 11 (2022)
Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by mutations of NLRP3 gene encoding cryopyrin. Familial cold autoinflammatory syndrome, the mildest form of CAPS, is characterized by cold-induced inflammation induc
Externí odkaz:
https://doaj.org/article/54eab856f68542b9915d303cd6a17e23
Autor:
Michiya SANO, Sayaka SHIMAZAKI, Yasuaki KANEKO, Tadayoshi KARASAWA, Masafumi TAKAHASHI, Akihide OHKUCHI, Hironori TAKAHASHI, Akira KUROSAWA, Yasushi TORII, Hisataka IWATA, Takehito KUWAYAMA, Koumei SHIRASUNA
Publikováno v:
The Journal of Reproduction and Development, Vol 66, Iss 3, Pp 241-248 (2020)
Maternal obesity is one of the major risk factors for pregnancy complications and is associated with low-grade chronic systemic inflammation due to higher levels of pro-inflammatory cytokines such as interleukin (IL)-1β. Pregnant women with obesity
Externí odkaz:
https://doaj.org/article/993315f2e71f4ad2880f68b2caef9ac5
Autor:
Naoya Yamada, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Takanori Komada, Ryo Kamata, Ariunaa Sampilvanjil, Junya Ito, Kiyotaka Nakagawa, Hiroshi Kuwata, Shuntaro Hara, Koichi Mizuta, Yasunaru Sakuma, Naohiro Sata, Masafumi Takahashi
Publikováno v:
Cell Death and Disease, Vol 11, Iss 2, Pp 1-16 (2020)
Abstract Acetaminophen (APAP) overdose is a common cause of drug-induced acute liver failure. Although hepatocyte cell death is considered to be the critical event in APAP-induced hepatotoxicity, the underlying mechanism remains unclear. Ferroptosis
Externí odkaz:
https://doaj.org/article/4c3e813c18814f5e811902c02c3b7717
Autor:
Emi Aizawa, Tadayoshi Karasawa, Sachiko Watanabe, Takanori Komada, Hiroaki Kimura, Ryo Kamata, Homare Ito, Erika Hishida, Naoya Yamada, Tadashi Kasahara, Yoshiyuki Mori, Masafumi Takahashi
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Pyroptosis is a form of regulated cell death that is characterized by gasdermin processing and increased membrane permeability. Caspase-1 and caspase-11 have been considered to be essential for gasdermin D processing associated with inflamma
Externí odkaz:
https://doaj.org/article/b76dceaede2544eaac2ccc4136359c28
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Reproduction involves tightly regulated series of events and the immune system is involved in an array of reproductive processes. Disruption of well-controlled immune functions leads to infertility, placental inflammation, and numerous pregnancy comp
Externí odkaz:
https://doaj.org/article/1172634ba7af4039a6e8234efe11ad2c
Autor:
Tadayoshi Karasawa, Masafumi Takahashi
Publikováno v:
Inflammation and Regeneration, Vol 37, Iss 1, Pp 1-7 (2017)
Abstract Atherosclerosis is an inflammatory disease, which is accompanied by the deposition of cholesterol-rich lipids and the infiltration of macrophages. Other well-known features of atherosclerotic lesions include the deposition of cholesterol cry
Externí odkaz:
https://doaj.org/article/5f74662222d14fc2a88e3326a6dcacf2
Autor:
Tadayoshi Karasawa, Akira Kawashima, Fumitake Usui, Hiroaki Kimura, Koumei Shirasuna, Yoshiyuki Inoue, Takanori Komada, Motoi Kobayashi, Yoshiko Mizushina, Junji Sagara, Masafumi Takahashi
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 348-356 (2015)
Increasing evidence indicates that caspase recruitment domain (CARD)‐mediated caspase‐1 (CASP1) assembly is an essential process for its activation and subsequent interleukin (IL)‐1β release, leading to the initiation of inflammation. Both CAR
Externí odkaz:
https://doaj.org/article/95e95b4fde7c4e91830b0160ad884702
Autor:
Motoi Kobayashi, Fumitake Usui-Kawanishi, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Nathan Mise, Fujio Kayama, Tadashi Kasahara, Naoyuki Hasebe, Masafumi Takahashi
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176676 (2017)
Cardiac glycosides such as digoxin are Na+/K+-ATPase inhibitors that are widely used for the treatment of chronic heart failure and cardiac arrhythmias; however, recent epidemiological studies have suggested a relationship between digoxin treatment a
Externí odkaz:
https://doaj.org/article/76bcf39fe93f46578d83bb2f31eab493