Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Tadayoshi Hasuma"'
Autor:
Shoji Fukushima, Yoshihisa Yano, Ai Matoba, Tomohiro Yano, Anna Kinoshita, Keiichirou Morimura, Shuzo Otani, Tadayoshi Hasuma, Hideki Wanibuchi
Publikováno v:
Experimental and Therapeutic Medicine. 1:657-661
Point mutations in oncogenes and tumor suppressor genes occur at early stages in the carcinogenic process. Point mutations in ras family oncogenes are the most common mutational events in several types of human cancer, and are available as molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1d50f4edff49c1d6ed519a5c549d32
https://doi.org/10.3892/etm_00000103
https://doi.org/10.3892/etm_00000103
Autor:
Isao Matsui-Yuasa, Tadayoshi Hasuma, Xuedan Huang, Akiko Kojima-Yuasa, Shenghui Xu, David Opare Kennedy
Publikováno v:
The American Journal of Chinese Medicine. 37:169-179
Hepatocellular carcinoma is a type of tumor highly resistant to available chemotherapeutic agents. The treatment of hepatocellular carcinoma remains a challenge that needs new approaches in the future. In a previous study, we demonstrated that the ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c5e9f552dc97cc6ecb6ad10222429a
https://doi.org/10.1142/s0192415x09006758
https://doi.org/10.1142/s0192415x09006758
Autor:
Akiko Kojima-Yuasa, Shenghui Xu, Isao Matsui-Yuasa, Tadayoshi Hasuma, David Opare Kennedy, Toshio Norikura, Xuedan Huang
Publikováno v:
The American Journal of Chinese Medicine. 36:729-744
Anticarcinogenic effects attributed to phytochemicals may be based on synergistic, additive, or antagonistic interactions of many compounds. In our previous study, we demonstrated that the chloroform fraction ( CHCl 3- F ) from Z. jujuba has anticanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5f46181aaba25fab52fb13b003201e
https://doi.org/10.1142/s0192415x08006193
https://doi.org/10.1142/s0192415x08006193
Autor:
Toshio Norikura, Xuedan Huang, David Opare Kennedy, Isao Matsui-Yuasa, Tadayoshi Hasuma, Akiko Kojima-Yuasa
Publikováno v:
The American Journal of Chinese Medicine. 35:517-532
The Zizyphus jujuba fruit has been used as a traditional Chinese medicinal herb and considered to affect various physiological functions in the body for thousands of years. However, its anti-cancer activity and mechanism of action remain to be elucid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ff11f01b90a11d0d703535a1f4bad3
https://doi.org/10.1142/s0192415x0700503x
https://doi.org/10.1142/s0192415x0700503x
Autor:
Yoshihisa Yano, Hitoshi Yamagiwa, Isao Matsui-Yuasa, Tadayoshi Hasuma, David Opare Kennedy, Shuzo Otani, Jerry Moffatt, Akiko Kojima
Publikováno v:
Cancer Letters. 179:25-32
Tea polyphenols have been shown to inhibit tumor cell growth, but there is limited information on their effects on cell signaling and cell cycle control pathways. We have shown the involvement of such mechanisms as activation of mitogenic activated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840746445e4e174828ec380289e21352
https://doi.org/10.1016/s0304-3835(01)00856-4
https://doi.org/10.1016/s0304-3835(01)00856-4
Autor:
Tetsuo Arakawa, Yasuhiro Fujiwara, Takayuki Matsumoto, Tadayoshi Hasuma, Takashi Takashima, Toshio Watanabe, Kazuhide Higuchi, Yoshihisa Yano, Kazunari Tominaga, Shuzo Otani, Nobuhide Oshitani
Publikováno v:
Alimentary Pharmacology & Therapeutics. 16:167-173
Background: Ornithine decarboxylase (ODC), a rate-limiting enzyme of polyamine biosynthesis, mediates epithelial cell proliferation and plays a critical role in the optimal repair of gastric mucosal damage. Several studies have shown that Helicobacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d11e3f494d24c7bfba230c0c84c23f32
https://doi.org/10.1046/j.1365-2036.16.s2.20.x
https://doi.org/10.1046/j.1365-2036.16.s2.20.x
Autor:
Koichi Koshimizu, Tadayoshi Hasuma, Hajime Ohigashi, David Opare Kennedy, Akira Murakami, Shuzo Otani, Akiko Kojima, Isao Matsui-Yuasa, Jerry Moffatt, Yoshihisa Yano
Publikováno v:
Chemico-Biological Interactions. 139:215-230
Elucidation of the mechanisms underlying potential anticancer drugs continues and unraveling these mechanisms would not only provide a conceptual framework for drug design but also promote use of natural products for chemotherapy. To further evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccba86445e38e17e2e1a0ae1a867260
https://doi.org/10.1016/s0009-2797(01)00301-5
https://doi.org/10.1016/s0009-2797(01)00301-5
Autor:
Katsumi Ikeda, Masakazu Yashiro, Kosei Hirakawa-Y.S. Chung, Tetsuro Ishikawa, Tadayoshi Hasuma, Tetsuji Sawada, Fumihiko Hato
Publikováno v:
International Journal of Cancer. 92:181-186
Breast-cancer cells frequently invade into the skin. However, few reports have described the mechanisms responsible for this invasion. In this study, we investigated the effects of skin fibroblasts on the invasion ability of breast-cancer cells, usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::439734a2439be1614e97cda346142302
https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1175>3.0.co
https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1175>3.0.co
Autor:
Shuzo Otani, David Opare Kennedy, Tadayoshi Hasuma, Isao Matsui-Yuasa, Satomi Nishimura, Yoshihisa Yano
Publikováno v:
Chemico-Biological Interactions. 110:159-172
Green tea extract and its polyphenolic components have been found to possess anticarcinogenic, antimutagenic, antihypertensive and antihepatotoxic effects, and several mechanisms have been proposed for these effects. In this study, the effects of fiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc80a093ce211dc91580bd4e0a2053a3
https://doi.org/10.1016/s0009-2797(98)00005-2
https://doi.org/10.1016/s0009-2797(98)00005-2
Autor:
Tadayoshi Hasuma, Kenjiro Otani, Tetsuo Arakawa, Yoshihisa Yano, Kenzo Kobayashi, Isao Matsui-Yuasa, Shuzo Otani
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 274:G299-G305
Oral administration of 1 ml of 3.42 M NaCl solution to rats induced spermidine/spermine N1-acetyltransferase (SSAT) activity in gastric mucosa as well as ornithine decarboxylase (ODC) activity. SSAT activity increased and peaked at 5 h and again at 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf415c5b1b33e40e28a250350142dfea
https://doi.org/10.1152/ajpgi.1998.274.2.g299
https://doi.org/10.1152/ajpgi.1998.274.2.g299