Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tadatsura Koshika"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 115, Iss 3, Pp 374-382 (2011)
The aim of the current study was to characterize comparatively the binding of muscarinic receptor in the lung of rats intratracheally administered anticholinergic agents (tiotropium, ipratropium, glycopyrrolate) used clinically to treat chronic obstr
Externí odkaz:
https://doaj.org/article/2d3ecc8f9ae64a1eb41bf89dfc6ba249
Autor:
Rie Yamamoto, Youhei Okada, Jun Hirose, Tadatsura Koshika, Yuka Kawato, Masashi Maeda, Rika Saito, Kazuyuki Hattori, Hironori Harada, Yasuhisa Nagasaka, Tatsuaki Morokata
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110819 (2014)
Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid that acts through the members of a family of five G protein-coupled receptors (S1P1-S1P5). S1P1 is a major regulator of lymphocyte trafficking, and fingolimod, whose active metabolit
Externí odkaz:
https://doaj.org/article/237719e5f8af4bd3b995d13d085e28fd
Autor:
Akira Okimoto, Masashi Maeda, Kazuyuki Hattori, Tatsuaki Morokata, Tadatsura Koshika, Kenichiro Shimatani, Jun Hirose, Rie Yamamoto
Publikováno v:
Transplantation proceedings. 51(6)
Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid that acts through the members of a family of 5 G protein-coupled receptors (S1P1 to S1P5). Among these, S1P1 is a major regulator of lymphocyte trafficking. Fingolimod, whose active
Autor:
Tadatsura Koshika, Seung Eun Lee, Hidetaka Hara, Minoru Fujita, David Ayares, Jason Fang, Carol Phelps, David K. C. Cooper
Publikováno v:
Immunology. 134:386-397
α1,3-Galactosyltransferase gene-knockout pigs transgenic for porcine cytotoxic T-lymphocyte antigen 4 immunoglobulin (pCTLA4-Ig) have been produced to reduce T-cell-mediated rejection following xenotransplantation. The level of soluble pCTLA4-Ig in
Publikováno v:
European Journal of Pharmacology. 515:169-178
The effects of tacrolimus on murine acute lung injury were tested, especially in comparison to dexamethasone. Acute lung injury was induced by intratracheal instillation of bleomycin. Oral tacrolimus significantly improved survival rates of bleomycin
Autor:
Ayako Moritomo, Tadatsura Koshika, Toru Kontani, Yuji Matsushima, Hiroshi Nagata, Hisao Hamaguchi, Shinya Nagashima, Makoto Takeuchi
Publikováno v:
Bioorganicmedicinal chemistry. 22(13)
Herein, we describe the synthesis and pharmacological profiles of novel quinuclidinyl heteroarylcarbamate derivatives. Among them, the quinuclidin-4-yl thiazolylcarbamate derivative ASP9133 was identified as a promising long-acting muscarinic antagon
Publikováno v:
Fundamental & Clinical Pharmacology. 11:512-518
The effects of NKH477, a water-soluble forskolin derivative, and dibutyryl-cyclic adenosine monophosphate (dbcAMP) on the release of adrenal catecholamines (CAs) in response to splanchnic nerve stimulation (SNS), acetylcholine (ACh), the nicotinic re
Publikováno v:
European Journal of Pharmacology. 327:135-141
We investigated the role of high conductance (BK(Ca)) and small conductance Ca2(+)-activated K+ (SK(Ca)) channels in adrenal catecholamine release in response to splanchnic nerve stimulation, acetylcholine, the nicotinic receptor stimulant 1,1-dimeth
Publikováno v:
Journal of Cardiovascular Pharmacology. 28:585-590
We examined the effects of glucagon on the release of adrenal catecholamines (CAs) in response to splanchnic nerve stimulation (SNS), acetylcholine (ACh), the nicotinic receptor stimulant 1,1-dimethyl-4-phenyl-piperazinium iodide (DMPP), and muscarin
Pretreatment with FK506 improves survival rate and gas exchange in canine model of acute lung injury
Publikováno v:
American journal of respiratory and critical care medicine. 163(1)
The novel effects of FK506 on shock induced by lipopolysaccharide and phorbol myristate acetate (LPS/PMA) were studied using beagles. Five groups were studied: endotoxin shock control group (both 0.5 mg/kg of LPS and 30 microg/kg of PMA, n = 6); meth