Výsledky vyhledávání - "Tadatsugu Sato"

Inhibition of Interferon Regulatory Factor-1 Expression Results in Predominance of Cell Growth Stimulatory Effects of Interferon-γ Due to Phosphorylation of Stat1 and Stat3

Autor: Neal S. Young, Carmine Selleri, Tadatsugu Sato, Jaroslaw P. Maciejewski

Publikováno v: Blood. 90:4749-4758

Interferon-gamma (IFN-gamma) is a potent inhibitor of hematopoiesis in vitro and has been implicated in the pathophysiology of human bone marrow failure syndromes. IFN-gamma both inhibits cell cycling and induces expression of the Fas-receptor, resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81ec60de9b2c608706fe374760ffa51
https://doi.org/10.1182/blood.v90.12.4749.4749_4749_4758

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Secondary colony formation after long-term bone marrow culture using peripheral blood and bone marrow of HIV-infected patients

Autor: Elaine M. Sloand, Jaroslaw P. Maciejewski, Frank F. Weichold, Neal S. Young, Tadatsugu Sato, Sonnie Kim, Princy Kumar

Publikováno v: AIDS. 11:1547-1553

OBJECTIVE: To determine if defective bone marrow function in HIV infection is associated with decreased numbers of progenitor cells or defective stromal cell function. DESIGN: Defective bone marrow function may in part be responsible for the cytopeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5d875cc1dc5038d418e4da1f2a7ec4
https://doi.org/10.1097/00002030-199713000-00002

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Impaired Hematopoiesis in Paroxysmal Nocturnal Hemoglobinuria/Aplastic Anemia Is Not Associated With a Selective Proliferative Defect in the Glycosylphosphatidylinositol-Anchored Protein-Deficient Clone

Autor: Tadatsugu Sato, Jaroslaw P. Maciejewski, Stacie M. Anderson, Neal S. Young, Elaine M. Sloand

Publikováno v: Blood. 89:1173-1181

Paroxysmal nocturnal hemoglobinuria (PNH) results from somatic mutations in the PIG-A gene, leading to poor presentation of glycosylphosphatidylinositol (GPI)-anchored surface proteins. PNH frequently occurs in association with suppressed hematopoies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52698416d4f89093fb5bc25719fba27c
https://doi.org/10.1182/blood.v89.4.1173

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Role of Fas Ligand and Receptor in the Mechanism of T-Cell Depletion in Acquired Immunodeficiency Syndrome: Effect on CD4+ Lymphocyte Depletion and Human Immunodeficiency Virus Replication

Autor: Frank F. Weichold, Jp Maciejewski, Tadatsugu Sato, N. S. Young, Elaine M. Sloand, P. Kumar

Publikováno v: Blood. 89:1357-1363

Direct killing of CD4+ lymphocytes by human immunodeficiency virus-1 (HIV-1) probably cannot account for the magnitude of the loss of these cells during the course of HIV-1 infection. Experimental evidence supports a pathophysiologic role of the apop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf74f7020dfce15170d3c4cf63289201
https://doi.org/10.1182/blood.v89.4.1357

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Involvement of Fas-Mediated Apoptosis in the Inhibitory Effects of Interferon-α in Chronic Myelogenous Leukemia

Autor: Luigi Del Vecchio, Neal S. Young, Jaroslaw P. Maciejewski, Tadatsugu Sato, Bruno Rotoli, A. John Barrett, Luigia Luciano, Carmine Selleri

Publikováno v: Blood. 89:957-964

Interferon-α (IFN-α) is an established treatment for chronic myelogenous leukemia (CML) in chronic phase, but the mechanism of its antileukemic activity is not clear. One possible mechanism of action might include the induction of apoptosis, and es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17cdcab7395c547c51732f8e75622d7
https://doi.org/10.1182/blood.v89.3.957

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A severe and consistent deficit in marrow and circulating primitive hematopoietic cells (long-term culture-initiating cells) in acquired aplastic anemia

Autor: Jaroslaw P. Maciejewski, Tadatsugu Sato, Stacie M. Anderson, Neal S. Young, Carmine Selleri

Publikováno v: Blood. 88:1983-1991

We examined the stem cell compartment of patients with acquired aplastic anemia (AA) using the long-term culture-initiating cell assay (LTC-IC), in parallel with measurements of CD34+ cells and mature hematopoietic progenitors. Secondary colonies fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69ccbf9f7b7affcd028ea537a9e58a4
https://doi.org/10.1182/blood.v88.6.1983.bloodjournal8861983

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Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition

Autor: Carmine Selleri, Jaroslaw P. Maciejewski, Neal S. Young, Tadatsugu Sato

Publikováno v: Blood. 87:4149-4157

Clinical and laboratory studies have suggested involvement of interferon-gamma (IFN-gamma) in the pathophysiology of aplastic anemia. T cells from aplastic anemia (AA) patients secrete IFN-gamma in vitro, activated cytotoxic lymphocytes infiltrate ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ff9b3e26b9192061a6c19c1969f1ab
https://doi.org/10.1182/blood.v87.10.4149.bloodjournal87104149

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Interferon-? and tumor necrosis factor-? suppress both early and late stages of hematopoiesis and induce programmed cell death

Autor: Stacie M. Anderson, Tadatsugu Sato, Neal S. Young, Carmine Selleri, Jaroslaw P. Maciejewski

Publikováno v: Journal of Cellular Physiology. 165:538-546

Increased expression of interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in bone marrow failure disorders suggests a possible pathophysiologic role of these cytokines in disease. In this study, we tested the action of TNF-alph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1dcd9ea301ed9dea25a7bd830693611
https://doi.org/10.1002/jcp.1041650312

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