Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Tadatoshi Kubota"'
Autor:
Kyoji Minami, Yasuhiro Nishitani, Hidenori Yoshizawa, Hikaru Itani, Hideaki Miwa, Tadatoshi Kubota
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:4221-4231
Among the prepared C-3′ substituted-pyridinium cephalosporins, a series of 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins bearing 4-[3-(aminoalkyl)-ureido]-1-pyridinium at C-3′ showed highly potent antibacterial act
Publikováno v:
Tetrahedron Letters. 36:8043-8046
lβ-Methylcarbapenems were efficiently synthesized utilizing acid- and rhodium(II)-catalyzed cyclization of iodonium ylide intermediates, which were easily prepared from the corresponding β-keto ester derivatives.
Publikováno v:
ChemInform. 24
Autor:
H. Nakashimizu, Kyoji Minami, T. Yoshida, Koji Ishikura, Kiyoshi Motokawa, Tadatoshi Kubota, Yoshio Hamashima
Publikováno v:
ChemInform. 25
Autor:
Hideaki Miwa, Kyoji Minami, Koji Ishikura, T. Yoshida, Kiyoshi Motokawa, Tadatoshi Kubota, H. Nakashimizu, Y. Kimura, Yoshio Hamashima
Publikováno v:
ChemInform. 25
Publikováno v:
ChemInform. 26
Publikováno v:
ChemInform. 27
lβ-Methylcarbapenems were efficiently synthesized utilizing acid- and rhodium(II)-catalyzed cyclization of iodonium ylide intermediates, which were easily prepared from the corresponding β-keto ester derivatives.
Autor:
Hideaki Miwa, Kyoji Minami, Yasuhiro Nishitani, Katsuki Yokoo, Koji Ishikura, Hidenori Yoshizawa, Tadatoshi Kubota, Tsutomu Iwaki, Tadashi Irie, Hikaru Itani
Publikováno v:
The Journal of antibiotics. 55(11)
A series of 7-aminothiadiazolylcephalosporins having a 1-(substituted)-1H-imidazo[4,5-b]pyridinium group at the C-3' position of the cephem nucleus were synthesized and evaluated for in vitro antibacterial activities. Among the cephalosporins prepare
Autor:
Masaharu Kume, Yoshinao Kobayashi, Tadatoshi Kubota, Masayoshi Doi, Kazuhisa Murakami, Hiroshi Nagata
Publikováno v:
The Journal of antimicrobial chemotherapy. 45(6)
The in vivo antibacterial activities of 7alpha-methoxy-cephems or 7alpha-methoxy-1-oxacephems and their demethoxy congeners after oral administration were compared in a mouse model of gastric infection with Helicobacter felis. The MICs of all four pa
Autor:
Koji Ishikura, Kiyoshi Motokawa, Yoshio Hamashima, Hiromu Nakashimizu, Kyoji Minami, Tadatoshi Kubota, Tadashi Yoshida
Publikováno v:
The Journal of antibiotics. 47(4)
Synthesis and biological activity of a series of 7 beta-[(Z)-2-(2- aminothiazol-4-yl)-3-(substituted)-2-propenoylamino]-3-cephe m-4-carboxylic acids and their pivaloyloxymethyl esters are described. These acid compounds exhibited potent antibacterial