Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Tadatoshi Kubota"'
2
Novel and efficient synthesis of 1β-methylcarbapenems utilizing cyclization of hypervalent iodonium ylides
Autor: Yasuyoshi Iso, Masaharu Kume, Tadatoshi Kubota
Publikováno v: Tetrahedron Letters. 36:8043-8046
lβ-Methylcarbapenems were efficiently synthesized utilizing acid- and rhodium(II)-catalyzed cyclization of iodonium ylide intermediates, which were easily prepared from the corresponding β-keto ester derivatives.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::543a4738915078b9a6cf1995ad01ca4f
https://doi.org/10.1016/0040-4039(95)01703-k
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7
ChemInform Abstract: Novel and Efficient Synthesis of 1β-Methylcarbapenems Utilizing Cyclization of Hypervalent Iodonium Ylides
Autor: Masaharu Kume, Yasuyoshi Iso, Tadatoshi Kubota
Publikováno v: ChemInform. 27
lβ-Methylcarbapenems were efficiently synthesized utilizing acid- and rhodium(II)-catalyzed cyclization of iodonium ylide intermediates, which were easily prepared from the corresponding β-keto ester derivatives.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::080ea08a158f7bbd07740f590642d303
https://doi.org/10.1002/chin.199608269
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8
S-3578, a new broad spectrum parenteral cephalosporin exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Synthesis and structure-activity relationships
Autor: Hideaki Miwa, Kyoji Minami, Yasuhiro Nishitani, Katsuki Yokoo, Koji Ishikura, Hidenori Yoshizawa, Tadatoshi Kubota, Tsutomu Iwaki, Tadashi Irie, Hikaru Itani
Publikováno v: The Journal of antibiotics. 55(11)
A series of 7-aminothiadiazolylcephalosporins having a 1-(substituted)-1H-imidazo[4,5-b]pyridinium group at the C-3' position of the cephem nucleus were synthesized and evaluated for in vitro antibacterial activities. Among the cephalosporins prepare
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b715ba96ac183afe08ee45b41e5a464
https://pubmed.ncbi.nlm.nih.gov/12546419
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9
The 7alpha-methoxy substituent in cephem or oxacephem antibiotics enhances in vivo anti-Helicobacter felis activity in mice after oral administration
Autor: Masaharu Kume, Yoshinao Kobayashi, Tadatoshi Kubota, Masayoshi Doi, Kazuhisa Murakami, Hiroshi Nagata
Publikováno v: The Journal of antimicrobial chemotherapy. 45(6)
The in vivo antibacterial activities of 7alpha-methoxy-cephems or 7alpha-methoxy-1-oxacephems and their demethoxy congeners after oral administration were compared in a mouse model of gastric infection with Helicobacter felis. The MICs of all four pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb4123af27f2b973165ea32f09c66c7
https://pubmed.ncbi.nlm.nih.gov/10837434
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10
Synthesis and structure-activity relationships of 7 beta-[(Z)-2-(2- aminothiazol-4-yl)-3-(substituted)-2-propenoyl-amino]-3- desacetoxymethylcephalosporins
Autor: Koji Ishikura, Kiyoshi Motokawa, Yoshio Hamashima, Hiromu Nakashimizu, Kyoji Minami, Tadatoshi Kubota, Tadashi Yoshida
Publikováno v: The Journal of antibiotics. 47(4)
Synthesis and biological activity of a series of 7 beta-[(Z)-2-(2- aminothiazol-4-yl)-3-(substituted)-2-propenoylamino]-3-cephe m-4-carboxylic acids and their pivaloyloxymethyl esters are described. These acid compounds exhibited potent antibacterial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a10945a71f6a6f39760d15f485ba97
https://pubmed.ncbi.nlm.nih.gov/8195046
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