Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tadashi Morikawa"'
Autor:
Tadashi Morikawa, Naoaki Murao, Haruhiko Sato, Hidetomo Kitamura, Yoshinobu Higuchi, Ryoichi Saitoh, Tatsuya Tamura
Publikováno v:
Arthritis Research & Therapy
Background Methotrexate (MTX) is one of the most widely used medications to treat rheumatoid arthritis (RA), and recent studies have also suggested the potential benefit of the drug for the treatment of osteoarthritis (OA) of the knee. MTX is commonl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153cea555b0bce75d2bfbcacead2446a
https://doi.org/10.1186/s13075-016-0971-8
https://doi.org/10.1186/s13075-016-0971-8
Autor:
Takenori Ishizawa, Koichi Takahashi, Kentaro Asanuma, Shigeo Sato, Kenji Nohmi, Ryohchi Suzuki, Tadashi Morikawa, Tomoyuki Watanabe, Yoshinobu Higuchi, Akie Homma, Tatsuya Tamura, Makoto Kanda, Noriyuki Izutani, Takashi Emura, Kazuaki Maeda, Hironoshin Kitagawa, Haruhiko Sato, Tadao Yamazaki, Masahisa Ikemi, Hitoshi Ikeya, Tetsu Matsuura, Tatsuya Kato, Akira Okamachi, Hidetomo Kitamura
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:1062-1075
We previously reported that a conjugate of hyaluronic acid (HA) and methotrexate (MTX) could be a prototype for future osteoarthritis drugs having the efficacy of the two clinically validated agents but with a reduced risk of the systemic side effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9e38bdd739bd26edc8ffc09e1081fb
https://doi.org/10.1016/j.bmc.2009.12.053
https://doi.org/10.1016/j.bmc.2009.12.053
Autor:
Teruzo Miyoshi, Sakayu Shimizu, Masaru Wada, Michihiko Kataoka, Tadashi Morikawa, Masahisa Ikemi
Publikováno v:
Annals of the New York Academy of Sciences. 864:318-322
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b214c1a4560a8fde9d13dc3577d6246b
https://doi.org/10.1111/j.1749-6632.1998.tb10330.x
https://doi.org/10.1111/j.1749-6632.1998.tb10330.x
Autor:
Hironoshin Kitagawa, Tadao Yamazaki, Makoto Kanda, Tomoyuki Watanabe, Tatsuya Tamura, Takenori Ishizawa, Haruhiko Sato, Tatsuya Kato, Noriyuki Izutani, Koichi Takahashi, Ryochi Suzuki, Masahisa Ikemi, Kentaro Asanuma, Shigeo Sato, Akira Okamachi, Yoshinobu Higuchi, Akie Homma, Hidetomo Kitamura, Kazuaki Maeda, Tadashi Morikawa, Hitoshi Ikeya, Tetsu Matsuura, Kenji Nohmi, Takashi Emura
Publikováno v:
Bioorganicmedicinal chemistry. 17(13)
Hyaluronic acid (HA) provides synovial fluid viscoelasticity and has a lubricating effect. Injections of HA preparations into the knee joint are widely used as osteoarthritis therapy. The current HA products reduce pain but do not fully control infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2554a522282b6398500465adad50ca47
https://pubmed.ncbi.nlm.nih.gov/19457673
https://pubmed.ncbi.nlm.nih.gov/19457673
Autor:
Hideaki Yamada, Michihiko Kataoka, Sakayu Shimizu, Teruzo Miyoshi, Masaaki Katoh, Tadashi Morikawa
Publikováno v:
Applied and Environmental Microbiology. 56:2374-2377
Enzyme-catalyzed asymmetric reduction of ethyl 4-chloro-3-oxobutanoate in an organic solvent-water diphasic system was studied. NADPH-dependent aldehyde reductase isolated from Sporobolomyces salmonicolor AKU4429 and glucose dehydrogenase were used a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc6ed61913a0e9c56f842723fb731ec
https://doi.org/10.1128/aem.56.8.2374-2377.1990
https://doi.org/10.1128/aem.56.8.2374-2377.1990
Autor:
Tatsuya Tamura, Yoshinobu Higuchi, Hidetomo Kitamura, Naoaki Murao, Ryoichi Saitoh, Tadashi Morikawa, Haruhiko Sato
Publikováno v:
Arthritis Research & Therapy; 4/1/2016, Vol. 18, p1-11, 11p
Autor:
Teruzo Miyoshi, Hideaki Yamada, Masahisa Ikemi, Masura Wada, Michihiko Kataoka, Tadashi Morikawa, Sakayu Shimizu, Ken-ichi Nishi
Publikováno v:
European journal of biochemistry. 248(2)
D-Threonine aldolase is an enzyme that catalyzes the cleavage of D-threonine into glycine and acetaldehyde. Its activity was found in several genera of bacteria such as Arthrobacter, Alcaligenes, Xanthomonas, and Pseudomonas, but not in yeasts or fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558aa843c8db072711c3af19f7dbe644
https://pubmed.ncbi.nlm.nih.gov/9346293
https://pubmed.ncbi.nlm.nih.gov/9346293
Autor:
Haruhiko Sato, Akie Homma, Takenori Ishizawa, Akira Okamachi, Takashi Emura, Tatsuya Kato, Tetsu Matsuura, Shigeo Sato, Masahisa Ikemi, Hironoshin Kitagawa, Tadashi Morikawa, Koichi Takahashi
Publikováno v:
HETEROCYCLES. 82:273
Optimal amidation conditions between hyaluronic acid (HA) and a methotrexate (MTX)-derived amine that gave rise to a HA-MTX conjugate having a molecular weight of ~2000 kDa have been established based on a model experiment using a tryptophan-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1b1a77559ecef5b059c7e0a8b520b6c
https://doi.org/10.3987/com-10-s(e)41
https://doi.org/10.3987/com-10-s(e)41
Autor:
Sakayu Shimizu, Hideaki Yamada, Teruzo Miyoshi, Masahisa Ikemi, Tadashi Morikawa, Michihiko Kataoka
Publikováno v:
Biochemical Engineering for 2001 ISBN: 9784431681823
D - β -Hydroxy - α - amino acids such as D-threonine are useful as the intermediate in the synthesis of chiral compounds such as antibiotics. It is difficult to synthesize D-threonine stereospecifically because of having two asymmetric carbons at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::319cd80ae53d718735f4149d3b894d84
https://doi.org/10.1007/978-4-431-68180-9_23
https://doi.org/10.1007/978-4-431-68180-9_23
Publikováno v:
Agricultural and Biological Chemistry. 49:1821-1828
In Candida tropicalis cells grown on n-alkanes (C10-C13), the levels of the activities of the enzymes related to fatty acid β—oxidation—acyl-CoA oxidase, enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase and 3-ketoacyl-CoA thiolase—were fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::056110a02da28e3ccd3b95bb03621f52
https://doi.org/10.1271/bbb1961.49.1821
https://doi.org/10.1271/bbb1961.49.1821