Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Tadashi Kusama"'
Autor:
Yoshio Ogawa, Fumio Ikegami, Atsuhiro Suda, Mayuko Ishii, Kazuko Watanabe, Kuniko Kusama-Eguchi, Takaaki Miyano, Kumiko Ishige, Yoshihisa Ito, Tadashi Kusama, Makoto Yamamoto
Publikováno v:
Food and Chemical Toxicology. 67:113-122
Neurolathyrism is a motor neuron (MN) disease caused by β-N-oxalyl-L-α,β-diaminopropionic acid (L-β-ODAP), an AMPA receptor agonist. L-β-ODAP caused a prolonged rise of intracellular Ca(2+) ([Ca(2+)]i) in rat spinal cord MNs, and the [Ca(2+)]i a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3669d6a523564914d962df759e25305
https://doi.org/10.1016/j.fct.2014.02.021
https://doi.org/10.1016/j.fct.2014.02.021
Autor:
Fumio Ikegami, Fernand Lambein, Tadashi Kusama, Kazuko Watanabe, Kuniko Kusama-Eguchi, Ai Minoura, Naduki Yoshino
Publikováno v:
Food and Chemical Toxicology. 49:636-643
Neurolathyrism is a motor neuron disease caused by the overconsumption of grass pea (Lathyrus sativus L.) containing L-β-ODAP. The precise mechanism to cause motor neuron degeneration has yet to be elucidated, but should agree with the epidemiologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44c578f3c956fd1e9ef5ea6d010d4eb
https://doi.org/10.1016/j.fct.2010.07.049
https://doi.org/10.1016/j.fct.2010.07.049
Autor:
Masahiro Kondo, Akiko Okada-Ogawa, Yoshiyuki Tsuboi, Koichi Iwata, Yoshiki Imamura, Tadashi Kusama
Publikováno v:
PAIN RESEARCH. 26:29-38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::555c38e4a818086517cc0ad6d3788834
https://doi.org/10.11154/pain.26.29
https://doi.org/10.11154/pain.26.29
Autor:
Tadashi Kusama, Peter J. Barnes, W. Mark Elliott, Kazuhiro Ito, Misako Ito, Marco Failla, James C. Hogg, Yasuo To, Yasuo Kizawa, Ian M. Adcock
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 182:897-904
Patients with chronic obstructive pulmonary disease (COPD) show a poor response to corticosteroids. This has been linked to a reduction of histone deacetylase-2 as a result of oxidative stress and is reversed by theophylline.To determine the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3433ce387a20ba3d6ab3caf511a0266
https://doi.org/10.1164/rccm.200906-0937oc
https://doi.org/10.1164/rccm.200906-0937oc
Autor:
Toyofumi Suzuki, Yasuo Kizawa, Keiko Kashiwagi, Yuta Nemoto, Muneharu Miyake, Rie Namiki, Kazuei Igarashi, Takashi Masuko, Tadashi Kusama
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 331:522-530
Tosyl-polyamine derivatives such as N-{4-[4-(guanidinobutylamino)-butylamino]butyl}-4-methylbenzenesulfonamide trihydrochroride (TsHSPMG) have been found to strongly inhibit macroscopic currents through heteromeric N-methyl-D-aspartate (NMDA) recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77a10f858730c3a366ad0bb933e7806
https://doi.org/10.1124/jpet.109.152926
https://doi.org/10.1124/jpet.109.152926
Autor:
Yasuo Kizawa, Keiko Kashiwagi, Takashi Masuko, Tadashi Kusama, Kuniko Kusama-Eguchi, Kazuei Igarashi, Tohru Koike, Eiichi Kimura, Muneharu Miyake
Publikováno v:
Neurochemistry International. 53:38-44
The linear polyamine spermine enhances N-methyl-d-aspartate (NMDA) receptors activity at depolarized membrane potential and shows a voltage-dependent block. Spermine potentiates NMDA receptor currents in the presence of saturating concentrations of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106c10c64b89b942108116d191aa9325
https://doi.org/10.1016/j.neuint.2008.04.009
https://doi.org/10.1016/j.neuint.2008.04.009
Publikováno v:
Journal of Heterocyclic Chemistry. 45:383-387
A novel water-soluble N-methyl-D-aspartate (NMDA) receptor antagonist ATGDMAP 1 as synthesized and the effect of 1 on NMDA receptors was studied using voltage-clamp recordings of recombinant NMDA receptors expressed in Xenopus oocytes. The compound 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a901881e41bbb9653ef4dff977cc5c0d
https://doi.org/10.1002/jhet.5570450214
https://doi.org/10.1002/jhet.5570450214
Autor:
Yoshio Ogawa, Kuniko Kusama-Eguchi, Kazuko Watanabe, Fumio Ikegami, Atsuhiro Suda, Tadashi Kusama
Publikováno v:
Journal of Natural Medicines. 60:107-112
Neurolathyrism is characterized by spastic paraparesis of the legs. It is caused by overconsumption of grass pea (Lathyrus sativus L.; Leguminosae). We studied toxicity of extracts of L. sativus seeds from two different areas—Bangladesh and Canada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57ab554aa4cf3f7955674dd1f02e34be
https://doi.org/10.1007/s11418-005-0020-4
https://doi.org/10.1007/s11418-005-0020-4
Autor:
Atsuhiro Suda, Kazuei Igarashi, Kuniko Kusama-Eguchi, Tadashi Kusama, Kazuko Watanabe, Fumio Ikegami, Yoshio Ogawa
Publikováno v:
Amino Acids. 28:139-143
Neurolathyrisim is a motor neuron disease characterized by spastic paraparesis in the hind legs, and is caused by grass pea, Lathyrus sativus, which contains the excitotoxic amino acid, 3-N-oxalyl-L: -2,3-diaminopropanoic acid (L: -beta-ODAP), an alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b1ed8c2a721b1bcde0990c1f2d5f48
https://doi.org/10.1007/s00726-005-0159-z
https://doi.org/10.1007/s00726-005-0159-z
Autor:
Keiko Kashiwagi, Ikuko Suzuki, Yasuo Kizawa, Kazuko Watanabe, Kuniko Kusama-Eguchi, Takashi Masuko, Tadashi Kusama, Kazuei Igarashi
Publikováno v:
Neuroscience Letters. 371:30-33
Dopamine has numerous functions in the brain and has been shown to modulate responses of N-methyl-D-aspartate (NMDA) receptors on thalamic and hippocampus neurons [N.G. Castro, M.C.F. de Mello, F.G. de Mello, Y. Aracava, Direct inhibition of the N-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514af073d97b4f5c22d6f88a873fe81f
https://doi.org/10.1016/j.neulet.2004.08.030
https://doi.org/10.1016/j.neulet.2004.08.030