Výsledky vyhledávání - "Tadashi Kurimoto"

Distinct Effects of Z-335, a New Thromboxane A2 Receptor Antagonist, on Rabbit Platelets and Aortic Smooth Muscle

Autor: Yukari Sato, Tokuro Shimura, Shigeyoshi Honma, Takao Tanaka, Makoto Yoshida, Tadashi Kurimoto, Satoko Ohkubo, Norimichi Nakahata

Publikováno v: Pharmacology. 79:50-56

The effect of a novel thromboxane A2 receptor (TP) antagonist, (±)-sodium[2-(4-chlorophenylsulfonylaminomethyl)- indan-5-yl]acetate monohydrate (Z-335), on the U46619-induced responses was compared between rabbit platelets and aorta. Z-335 inhibited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9959547bb5bb9511f831d9867a5c865f
https://doi.org/10.1159/000097632

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Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages

Autor: Takashi Ohashi, Takao Masuda, Tamako Ikeda, Mineo Takei, Yutaka Emori, Tadashi Kurimoto, Mari Kannagi

Publikováno v: Journal of General Virology. 85:2603-2613

Z-100 is an arabinomannan extracted fromMycobacterium tuberculosisthat has various immunomodulatory activities, such as the induction of interleukin 12, interferon gamma (IFN-γ) andβ-chemokines. The effects of Z-100 on human immunodeficiency virus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694e847cbb376d7cccd1e80071a5de2c
https://doi.org/10.1099/vir.0.80046-0

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Drug–drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338

Autor: Keiko Yonezawa, Tohru Sugimoto, Shigeru Furuta, Takeshi Omata, Tadashi Kurimoto, Yoshihiro Kawabata, Xiaochun Cheryl Wu, Emiko Kamada

Publikováno v: European Journal of Pharmacology. 497:223-231

In the present study, the inhibitory properties of N-[2-(diisopropylamino)ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide monohydrochloride trihydrate (Z-338), a novel gastroprokinetic agent, were investigated and compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c15352b253c1c18ab4007adb4e47f3
https://doi.org/10.1016/j.ejphar.2004.06.040

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ATP-Dependent Transport of a Novel Thromboxane A2Receptor Antagonist, [2-(4-Chlorophenylsulfonylaminomethyl)-Indan-5-yl]Acetate (Z-335) and Its Xenobiotic Taurine Conjugate (Z-335-Tau) by Rat Bile Canalicular Membrane Vesicles

Autor: Shigeru Furuta, Mineo Takei, Emiko Kamada, Yoshihiro Kawabata, Kazuho Okudaira, Ryuichiro Nishigaki, Tadashi Kurimoto

Publikováno v: Pharmaceutical Research. 21:467-475

The characteristics of bile canalicular transport processes for xenobiotic taurine conjugates have not yet been clarified. To elucidate the biliary excretion characteristics of xenobiotic taurine conjugates, we investigated the transport of a novel t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c89f0f7e5723aff2dd855d6989bddfc
https://doi.org/10.1023/b:pham.0000019301.97624.5b

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Involvement of CYP2C9 and UGT2B7 in the metabolism of zaltoprofen, a nonsteroidal anti-inflammatory drug, and its lack of clinically significant CYP inhibition potential

Autor: Akio Hiyama, Atsuhiro Inaba, Nobuhiko Kowata, Emiko Kamada, Shigeru Furuta, Michael Hall, Nobuyoshi Akagawa, Anne Matthews, Yoshihiro Kawabata, Tadashi Kurimoto

Publikováno v: British Journal of Clinical Pharmacology. 54:295-303

Aims To identify the cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) isoforms responsible for the formation of the primary metabolite(s) of zaltoprofen, and to predict possible drug interactions by investigating the inhibition of CYP isof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b1511ecee7bcf1c3b346ae9287f6d79
https://doi.org/10.1046/j.1365-2125.2002.01649.x

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Anti-Tumor Mechanism of Z-100, an Immunomodulatory Arabinomannan Extracted fromMycobacterium tuberculosisStrain Aoyama B, on Pulmonary Metastases of B16F10 Melanoma: Restoration of Helper T Cell Responses via Suppression of Glucocorticoid-Genesis

Autor: Hideaki oka, Koji Yoshinaga, Yumiko Shiraishi, Hidetaka Sasaki, Yutaka Emori, Tadashi Kurimoto

Publikováno v: Microbiology and Immunology. 46:343-351

In the present study, the anti-tumor mechanism of Z-100 was investigated with the use of pulmonary metastasis of B16F10 melanoma. In B16F10 mice, Th1 cytokine production (IL-2, IFN-gamma) was suppressed in comparison with normal mice. On the other ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a9fc646843051129550f053cf58712
https://doi.org/10.1111/j.1348-0421.2002.tb02705.x

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Carrier-Mediated Active Transport of a Novel Thromboxane A2 Receptor Antagonist [2-(4-Chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335) into Rat Liver

Autor: Yoshihiro Kawabata, Shigeru Furuta, Ryuichiro Nishigaki, Tadashi Kurimoto, Yutaka Shinozaki

Publikováno v: Drug Metabolism and Disposition. 30:498-504

To elucidate the transport system by which [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335) is taken up into the liver, we investigated the uptake characteristics of Z-335 in isolated rat hepatocytes. In addition, we estimated the hep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b54a55e98edf673f114c70021383945
https://doi.org/10.1124/dmd.30.5.498

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Pharmacodynamic analysis of steroid 5α-reductase inhibitory actions of Z-350 in rat prostate

Autor: Yoshihisa Fukuta, Youich Fukuda, Tohru Sugimoto, Shigeru Furuta, Mineo Takei, Hiroshi Sano, Haruka Miyahara, Tadashi Kurimoto, Emiko Kamada

Publikováno v: European Journal of Pharmacology. 426:105-111

The pharmacodynamics of (S)-4-[3-[4-[1-(4-methylphenyl)-3-[4-(2-methoxyphenyl)piperazine-1-yl]propoxy]benzoyl]indole-1-yl] butyric acid hydrochloride (Z-350), which has alpha(1)-adrenoceptor antagonistic and steroid 5alpha-reductase inhibitory effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca417044a71859bc5f0a3076faa6eed
https://doi.org/10.1016/s0014-2999(01)01208-0

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Hormonal Effects of Z-350, Possessing Steroid 5 a-Reductase Inhibitory and a ι-Adrenoceptor Antagonistic Actions, in the Rat

Autor: Youichi Fukuda, Mineo Takei, Masayuki Ogishima, Tadashi Kurimoto, Yoshihisa Fukuta, Kenji Yoshida, Raita Higashino

Publikováno v: Japanese Journal of Pharmacology. 86:323-328

We examined the hormonal effects of Z-350, (S)-4-[3-(4-{1-(4-methylphenyl)-3-[4-(2-meth-oxyphenyl)piperazine-1-yl]propoxy|benzoyl)indole-1-yl]butyric acid hydrochloride, which has both α1-adrenoceptor blocking activity and steroid 5α -reductase inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0e93739b3ac4d0be82f310ddc3c84f9
https://doi.org/10.1254/jjp.86.323

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Z-335, a new thromboxane A2 receptor antagonist, prevents arterial thrombosis induced by ferric chloride in rats

Autor: Tadashi Kurimoto, Ryuichi Sato, Takao Tanaka

Publikováno v: European Journal of Pharmacology. 401:413-418

We examined the antithrombotic effect of Z-335 ((+/-)-sodium [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate monohydrate), an orally active thromboxane A(2) receptor (TP-receptor) antagonist that ameliorates experimental gangrene, using a ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9372b71e2a3684975a834ef19d5fdbd
https://doi.org/10.1016/s0014-2999(00)00434-9

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