Výsledky vyhledávání - "Tadashi Imaoka"

Structure–activity relationship of α hormones, the mating factors of phytopathogen Phytophthora

Autor: Jianhua Qi, Arata Yajima, Goro Yabuta, Makoto Ojika, Tomoo Nukada, Shylaja D. Molli, Tadashi Imaoka, Keisuke Shikai

Publikováno v: Bioorganic & Medicinal Chemistry. 20:681-686

The mating hormones α1 and α2 induce sexual reproduction of the phytopathogenic genus Phytophthora. To demonstrate the structural elements responsible to hormonal activity, 17 derivatives of α1 and α2 were synthesized and their hormonal activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230438bf308b0203f932940c00d7372f
https://doi.org/10.1016/j.bmc.2011.12.015

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Abstract A169: Combination of TPC-144, a reversible LSD1 inhibitor, and a hypomethylating agent resulted in synergistic antitumor efficacy in preclinical models of AML

Autor: Yoshikazu Iwasawa, Takahiro Ogawa, Takumitsu Machida, Aki Kawagishi, Akiko Osada, Kenichi Matsuo, Teruhiro Utsugi, Satoshi Yamashita, Ryo Hatanaka, Kenjiro Ito, Tadashi Imaoka

Publikováno v: Molecular Cancer Therapeutics. 17:A169-A169

Background: Lysine-specific demethylase 1A (LSD1/KDM1A) is a flavin adenine dinucleotide (FAD)-dependent histone demethylase that specifically modifies histone H3 lysine 4 and lysine 9. LSD1 activity is implicated in the pathogenesis of several human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::053c529424e1a9d4d0cbc7f813e0f71c
https://doi.org/10.1158/1535-7163.targ-17-a169

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