Výsledky vyhledávání - "Tadashi Hakomori"

Development of extended-release solid dispersion granules of tacrolimus: evaluation of release mechanism and human oral bioavailability

Autor: Daisuke Tsunashima, Tadashi Hakomori, Kazutaka Higaki, Kazunari Yamashita, Kazuhiro Sako, Ken Ichi Ogawara

Publikováno v: Journal of Pharmacy and Pharmacology. 69:1697-1706

Objectives We aimed to prepare a once-daily modified-release oral formulation of tacrolimus by utilizing an extended-release granules (ERG). Methods Extended-release granules were prepared using ethylcellulose (EC), hydroxypropylmethylcellulose (HPMC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d16edaf2340f2cb8edd69cea5b5f93
https://doi.org/10.1111/jphp.12804

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Application of Terahertz Attenuated Total Reflection Spectroscopy to Detect Changes in the Physical Properties of Lactose during the Lubrication Process Required for Drug Formulation

Autor: Kazunari Yamashita, Masafumi Dohi, Katsuhide Terada, Wataru Momose, Tadashi Hakomori, Shusaku Sato, Shuji Noguchi

Publikováno v: CHEMICAL & PHARMACEUTICAL BULLETIN. 65:186-193

Manufacturing the solid dosage form of an orally administered drug requires lubrication to enhance manufacturability, ensuring that critical quality attributes such as disintegration and dissolution of the drug product are maintained during manufactu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa6e60b59a21ef3beb6d344e2e3776c
https://doi.org/10.1248/cpb.c16-00824

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Novel approach to evaluating granulation and segregation level considering the contribution of hydroxypropyl cellulose to the surface property change of granules

Autor: Tadashi Hakomori, Etsuo Yonemochi, Kazunari Sato, Masafumi Dohi, Hirotaka Ando, Yusuke Nozaki

Publikováno v: International journal of pharmaceutics. 581

The granulation process is critical to the uniformity of not only the active ingredient (API) but also other excipients in granules. Insufficient granulation results in unexpected product quality, e.g. delayed dissolution and lack of uniformity of AP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06289a6f16879f2554dc7aeb68eb76d2
https://pubmed.ncbi.nlm.nih.gov/32220585

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New approach to optimizing risk management of the sticking problem using scale-independent critical material attributes and the quantitative process parameter

Autor: Yuko Hara, Tadashi Hakomori, Etsuo Yonemochi, Hirotaka Ando, Masafumi Dohi, Kazunari Sato

Publikováno v: International journal of pharmaceutics. 577

In pharmaceutical manufacturing of solid formulations, blending with a lubricant is a key process in preventing sticking during compression. Sticking not only results in tablets with a disfigured appearance but also brings about the interruption of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63790ddea418efce80b17aea2c53812
https://pubmed.ncbi.nlm.nih.gov/31953089

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Application of terahertz pulse imaging as PAT tool for non-destructive evaluation of film-coated tablets under different manufacturing conditions

Autor: Katsuhide Terada, Wataru Momose, Hiroyuki Yoshino, Kazunari Yamashita, Tadashi Hakomori, Masafumi Dohi, Yuko Hara, Shusaku Sato

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 119:104-113

Film-coated tablets (FCTs) are a popular solid dosage form in pharmaceutical industry. Manufacturing conditions during the film-coating process affect the properties of the film layer, which might result in critical quality problems. Here, we analyze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d61204027c4318013ff3d9f15faa82
https://doi.org/10.1016/j.jpba.2015.11.046

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Impact of process parameters on Mg–St content and tablet surface wettability in the external lubrication method for a rotary tablet press

Autor: Yasunori Iwao, Shuji Noguchi, Kazunari Yamashita, Hiroyuki Hiroma, Hisami Kondo, Tadashi Hakomori, Kazuhiro Sako, Shigeru Itai, Takayuki Kamiya

Publikováno v: Advanced Powder Technology. 27:193-198

External lubrication is a new alternative used in compression processes of the pharmaceutical industry to minimize the negative effect of lubricant and to resolve sticking problems. This method can also prevent the deterioration of tablet properties;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64c4ff4afee9b35c76c9adbbf3d13db0
https://doi.org/10.1016/j.apt.2015.11.012

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Use of Mixer Torque Rheometer to Clarify the Relationship between the Kneading States of Wet Mass and the Dissolution of Final Product in High Shear Granulation

Autor: Tadashi Hakomori, Tomoko Otsuka, Shigeru Itai, Yasunori Iwao, Kazunari Sato, Shin-ichiro Kimura, Kazunari Yamashita, Yosuke Kuroiwa

Publikováno v: Chemicalpharmaceutical bulletin. 66(5)

The properties of wet mass, which indicate the progress of high shear granulation processes, usually have an effect on final product properties, such as tablet dissolution. The mixer torque rheometer (MTR) is a useful tool for quantitatively measurin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9a41fe2628d7aa6db997bc7d32b2fa
https://pubmed.ncbi.nlm.nih.gov/29710051

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