Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Tadashi, Kasahara"'
Autor:
Emi Aizawa, Tadayoshi Karasawa, Sachiko Watanabe, Takanori Komada, Hiroaki Kimura, Ryo Kamata, Homare Ito, Erika Hishida, Naoya Yamada, Tadashi Kasahara, Yoshiyuki Mori, Masafumi Takahashi
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Pyroptosis is a form of regulated cell death that is characterized by gasdermin processing and increased membrane permeability. Caspase-1 and caspase-11 have been considered to be essential for gasdermin D processing associated with inflamma
Externí odkaz:
https://doaj.org/article/b76dceaede2544eaac2ccc4136359c28
Autor:
Motoi Kobayashi, Fumitake Usui-Kawanishi, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Nathan Mise, Fujio Kayama, Tadashi Kasahara, Naoyuki Hasebe, Masafumi Takahashi
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176676 (2017)
Cardiac glycosides such as digoxin are Na+/K+-ATPase inhibitors that are widely used for the treatment of chronic heart failure and cardiac arrhythmias; however, recent epidemiological studies have suggested a relationship between digoxin treatment a
Externí odkaz:
https://doaj.org/article/76bcf39fe93f46578d83bb2f31eab493
Autor:
Yuki Uchihara, Fumihito Ueda, Kenji Tago, Yosuke Nakazawa, Tomoyuki Ohe, Tadahiko Mashino, Shigenobu Yokota, Tadashi Kasahara, Hiroomi Tamura, Megumi Funakoshi-Tago
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183003 (2017)
Anaplastic large cell lymphomas (ALCL) are mainly characterized by harboring the fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). The ALK inhibitor, crizotinib specifically induced apoptosis in Ba/F3 cells expressing NPM-ALK by inhi
Externí odkaz:
https://doaj.org/article/59286be9e99243a18acffd284832b14e
Autor:
Yoshiyuki Inoue, Nathan Mise, Ryo Kamata, Tadayoshi Karasawa, Sachiko Watanabe, Hiroaki Kimura, Fumitake Usui-Kawanishi, Tadashi Kasahara, Takanori Komada, Masafumi Takahashi
Publikováno v:
Journal of Cellular Physiology. 235:7554-7566
Although the intimate linkage between hypoxia and inflammation is well known, the mechanism underlying this linkage has not been fully understood. Nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c590a3462d1943322b9a21256507f36f
https://doi.org/10.1002/jcp.29659
https://doi.org/10.1002/jcp.29659
Autor:
Tadashi Kasahara, Yoshio Honma, Hisayoshi Kobayashi, Kyoko Akano, Michio Namikoshi, Taiko Oda
Publikováno v:
Marine Drugs, Vol 3, Iss 2, Pp 64-73 (2005)
Abstract: Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell li
Externí odkaz:
https://doaj.org/article/226cc12ba6ea4304aeea378d5535792c
Autor:
Kenichi Aizawa, Takanori Komada, Ryo Kamata, Yoshiko Mizushina, Masafumi Takahashi, Tadashi Kasahara, Shinichiro Koyama, Naoko Mato, Masashi Bando, Koichi Hagiwara, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe
Publikováno v:
The Journal of Immunology. 203:236-246
Inflammation plays a pivotal role in the pathophysiology of gastric aspiration–induced acute lung injury (ALI). However, its mechanism remains unclear. In this study, we investigated the role of NLRP3 inflammasome–driven IL-1β production in a mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b850d88be29102f49ad5c0207ed0c0
https://doi.org/10.4049/jimmunol.1900168
https://doi.org/10.4049/jimmunol.1900168
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52844 (2013)
The acquired mutation (V617F) of Janus kinase 2 (JAK2) is observed in the majority of patients with myeloproliferative neoplasms (MPNs). In the screening of genes whose expression was induced by JAK2 (V617F), we found the significant induction of c-M
Externí odkaz:
https://doaj.org/article/a57e2be08dbd43c1b18b58d5cf01f6bd
Autor:
Takahashi, Reiko, Sonoda, Yoshiko, Ichikawa, Daiju, Yoshida, Naomi, Eriko, Aizu-Yokota, Tadashi, Kasahara
Publikováno v:
In BBA - General Subjects 2007 1770(4):518-526
Publikováno v:
Mediators of Inflammation, Vol 2010 (2010)
Mucosal damage is a common side effect of many cancer treatments, especially radiotherapy and intensive chemotherapy, which often induce bone marrow (BM) suppression. We observed that acetic acid- (AA-) induced mucosal damage in the colon of mice was
Externí odkaz:
https://doaj.org/article/c7af8fd632114a6dae5b9e9c6781a23d
Autor:
Ai Sadatomo, Tadayoshi Karasawa, Sachiko Watanabe, Hiroaki Kimura, Naohiro Sata, Tadashi Kasahara, Masafumi Takahashi, Yoshiyuki Inoue, Homare Ito, Ryo Kamata, Yoshiko Mizushina, Hisanaga Horie, Jun Nakamura
Publikováno v:
The Journal of Immunology. 199:3306-3315
Accumulating evidence suggests that IL-1β plays a pivotal role in the pathophysiology of hepatic ischemia–reperfusion (I/R) injury; however, the mechanism by which I/R triggers IL-1β production in the liver remains unclear. Recent data have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df74960bba204f13ca7c13929e70fb1c
https://doi.org/10.4049/jimmunol.1700717
https://doi.org/10.4049/jimmunol.1700717