Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Tadao Shibasaki"'
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Akademický článek
Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion
Autor: Ghupurjan Gheni, Masahito Ogura, Masahiro Iwasaki, Norihide Yokoi, Kohtaro Minami, Yasumune Nakayama, Kazuo Harada, Benoit Hastoy, Xichen Wu, Harumi Takahashi, Kazushi Kimura, Toshiya Matsubara, Ritsuko Hoshikawa, Naoya Hatano, Kenji Sugawara, Tadao Shibasaki, Nobuya Inagaki, Takeshi Bamba, Akira Mizoguchi, Eiichiro Fukusaki, Patrik Rorsman, Susumu Seino
Publikováno v: Cell Reports, Vol 9, Iss 2, Pp 661-673 (2014)
Incretins, hormones released by the gut after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion. The effect of incretins on insulin secretion occurs only at elevated glucose concentrations and
Externí odkaz: https://doaj.org/article/63c84696f9bd4fb8a77b9baf72fed23b
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4
Evaluation of cerebrospinal fluid heparan sulfate as a biomarker of neuropathology in a murine model of mucopolysaccharidosis type II using high-sensitivity LC/MS/MS
Autor: Tadao Shibasaki, Ryuji Yamamoto, Sachiho Kida, Masafumi Kinoshita, Hideto Morimoto, Noboru Tanaka, Katsuhiko Tachibana
Publikováno v: Molecular genetics and metabolism. 125(1-2)
Mucopolysaccharidosis type II (MPS II or Hunter syndrome) is a lysosomal storage disorder caused by a deficiency of iduronate-2-sulfatase (IDS), an enzyme that catabolizes glycosaminoglycans (GAGs) including heparan sulfate (HS) and dermatan sulfate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6df7c1bf73931b3f51cd0bcd14900b
https://pubmed.ncbi.nlm.nih.gov/30064964
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6
Actin Dynamics Regulated by the Balance of Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP) and Cofilin Activities Determines the Biphasic Response of Glucose-induced Insulin Secretion
Autor: Takao Yasuda, Hitomi Hamaguchi, Tadao Shibasaki, Yutaka Oiso, Susumu Seino, Masato Tatebe, Harumi Takahashi, Tadaomi Takenawa, Chihiro Seki, Eita Uenishi
Publikováno v: Journal of Biological Chemistry. 288:25851-25864
Actin dynamics in pancreatic β-cells is involved in insulin secretion. However, the molecular mechanisms of the regulation of actin dynamics by intracellular signals in pancreatic β-cells and its role in phasic insulin secretion are largely unknown
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82f1972cf850672dff82480e58b9b6e
https://doi.org/10.1074/jbc.m113.464420
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7
Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion
Autor: Ritsuko Hoshikawa, Tadao Shibasaki, Kenji Sugawara, Toshiya Matsubara, Benoit Hastoy, Masahito Ogura, Eiichiro Fukusaki, Kazuo Harada, Takeshi Bamba, Ghupurjan Gheni, Xichen Wu, Yasumune Nakayama, Susumu Seino, Nobuya Inagaki, Masahiro Iwasaki, Harumi Takahashi, Akira Mizoguchi, Naoya Hatano, Kohtaro Minami, Kazushi Kimura, Norihide Yokoi, Patrik Rorsman
Publikováno v: Cell Reports
Cell Reports, Vol 9, Iss 2, Pp 661-673 (2014)
Summary Incretins, hormones released by the gut after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion. The effect of incretins on insulin secretion occurs only at elevated glucose concentrat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8880fbe6946ffcf705e39bfb7b8a654f
https://ora.ox.ac.uk/objects/uuid:abe5ec6a-9cb7-419e-ab49-2b02c2a26e9f
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8
GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis
Autor: Yang De Marinis, Stefan Amisten, Patrik Rorsman, Yusuke Moritoh, Tadao Shibasaki, Martin Bengtsson, Susumu Seino, Reshma Ramracheya, Quan Zhang, Orit Braha, Enming Zhang, Fernando Abdulkader, Albert Salehi, Erik Renström, Matthias Braun, Fiona M. Gribble, Frank Reimann, Caroline E. Ward, Lena Eliasson, Abdella M. Habib, Anders Rosengren
Publikováno v: Cell Metabolism; 11(6), pp 543-553 (2010)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Glucagon secretion is inhibited by glucagon-like peptide-1 (GLP-1) and stimulated by adrenaline. These opposing effects on glucagon secretion are mimicked by low (1-10 nM) and high (10 muM) concentrations of forskolin, respectively. The expression of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b2f94a42a3a0ea06c89c48e1538c3f
https://doi.org/10.1016/j.cmet.2010.04.007
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9
Elucidation of the function and role of cAMP sensor Epac2A in insulin secretion
Autor: Tadao Shibasaki
Publikováno v: Diabetology International. 3:187-196
Insulin secretion is regulated by various intracellular signals including Ca2+, ATP, cAMP, and phospholipid-derived signals. Although glucose-induced insulin secretion (GIIS) is the principal mechanism of insulin secretion, its potentiation by cAMP i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30535dc287ae3efd2f6df3d00522c691
https://doi.org/10.1007/s13340-012-0094-7
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10
Treating diabetes today: a matter of selectivity of sulphonylureas
Autor: Harumi Takahashi, Tadao Shibasaki, Toshimasa Takahashi, Susumu Seino
Publikováno v: Diabetes, Obesity and Metabolism. 14:9-13
It is well known that sulphonylureas (SUs), commonly used in the treatment of type 2 diabetes mellitus, stimulate insulin secretion by closing ATP-sensitive K(+) (K(ATP) ) channels in pancreatic β-cells by binding to the SU receptor SUR1. SUs are no
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771a6135623443dd9da63e31e78eb7ca
https://doi.org/10.1111/j.1463-1326.2011.01507.x
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