Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Tadanori Tomita"'
Autor:
Nitin Wadhwani, Sonali Nayak, Yufen Wang, Rintaro Hashizume, Chunfa Jie, Barbara Mania-Farnell, Charles David James, Guifa Xi, Tadanori Tomita
Publikováno v:
Cancers, Vol 15, Iss 13, p 3429 (2023)
Pediatric high-grade gliomas (pHGGs) are common malignant brain tumors without effective treatment and poor patient survival. Abnormal posttranslational modification at the histone H3 tail plays critical roles in tumor cell malignancy. We have previo
Externí odkaz:
https://doaj.org/article/2708f9fc098d4b069bb90de5c206c164
Autor:
S. Joy Trybula, Mark W. Youngblood, Hanna R. Kemeny, Jeffrey R. Clark, Constantine L. Karras, William F. Hartsell, Tadanori Tomita
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Radiation induced cavernomas among children with medulloblastoma are common following external beam radiation (XRT) treatment with either photon or proton beams. However, with the increased utilization of proton beam therapy over the last decade we s
Externí odkaz:
https://doaj.org/article/fdf137679d8340ffa5c582d4dc117b03
Autor:
Rebecca Lewis, Yuping D Li, Lindsey Hoffman, Rintaro Hashizume, Gordan Gravohac, Gavin Rice, Nitin R Wadhwani, Chunfa Jie, Tatiana Pundy, Barbara Mania-Farnell, Chandra S Mayanil, Marcelo B Soares, Ting Lei, Charles D James, Nicolas K Foreman, Tadanori Tomita, Guifa Xi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 6, Pp 505-515 (2019)
BACKGROUND: Ependymomas (EPNs) are the third most common brain tumor in children. These tumors are resistant to available chemotherapeutic treatments, therefore new effective targeted therapeutics must be identified. Increasing evidence shows epigene
Externí odkaz:
https://doaj.org/article/6863059839ef4cb38ffe94340dddc14d
Autor:
Tina Y. Huang, Andrea Piunti, Rishi R. Lulla, Jin Qi, Craig M. Horbinski, Tadanori Tomita, C. David James, Ali Shilatifard, Amanda M. Saratsis
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-12 (2017)
Abstract Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise in young children and are not surgically resectable. These tumors are characterize
Externí odkaz:
https://doaj.org/article/5b0fa5b8d5af4d58a2000afafe4e9abf
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 4, Pp 261-270 (2017)
Human glioma, in particular, malignant forms such as glioblastoma exhibit dismal survival rates despite advances in treatment strategies. A population of glioma cells with stem-like features, glioma cancer stem-like cells (GCSCs), contribute to renew
Externí odkaz:
https://doaj.org/article/1d1bc7d3a7734dada2830214bc6a3627
Publikováno v:
Cancers, Vol 12, Iss 9, p 2621 (2020)
Suprasellar germ cell tumors (S-GCTs) are rare, presenting in either solitary or multifocal fashion. In this study, we retrospectively examine 22 solitary S-GCTs and 20 bifocal germ cell tumors (GCTs) over a 30-year period and demonstrate clinical, r
Externí odkaz:
https://doaj.org/article/e020788015494be6a0db5b7dafd49376
Autor:
Sonali Nayak, Ashorne Mahenthiran, Yongyong Yang, Mark McClendon, Barbara Mania-Farnell, Charles David James, John A. Kessler, Tadanori Tomita, Shi-Yuan Cheng, Samuel I. Stupp, Guifa Xi
Publikováno v:
Cancers, Vol 12, Iss 2, p 516 (2020)
Malignant gliomas are heterogeneous neoplasms. Glioma stem-like cells (GSCs) are undifferentiated and self-renewing cells that develop and maintain these tumors. These cells are the main population that resist current therapies. Genomic and epigenomi
Externí odkaz:
https://doaj.org/article/cbdc51fd2f4a42c1bfd22d6d2af32ebc
Autor:
Sergey Malchenko, Simone Treiger Sredni, Yingtao Bi, Naira V Margaryan, Jerusha Boyineni, Indra Mohanam, Tadanori Tomita, Ramana V Davuluri, Marcelo B Soares
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173106 (2017)
Recently, we described a new animal model of CNS primitive neuroectodermal tumors (CNS-PNET), which was generated by orthotopic transplantation of human Radial Glial (RG) cells into NOD-SCID mice's brain sub-ventricular zone. In the current study we
Externí odkaz:
https://doaj.org/article/41760d633d714e17b447fa3c3bd9d82b
Autor:
Amreena Suri, Anders W. Bailey, Maurício T. Tavares, Hendra Gunosewoyo, Connor P. Dyer, Alex T. Grupenmacher, David R. Piper, Robert A. Horton, Tadanori Tomita, Alan P. Kozikowski, Saktimayee M. Roy, Simone T. Sredni
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2112 (2019)
Polo-like kinase 4 (PLK4) is a cell cycle-regulated protein kinase (PK) recruited at the centrosome in dividing cells. Its overexpression triggers centrosome amplification, which is associated with genetic instability and carcinogenesis. In previous
Externí odkaz:
https://doaj.org/article/aa0a2fae070a4cd0977b4011fb458371
Autor:
Anders W. Bailey, Amreena Suri, Pauline M. Chou, Tatiana Pundy, Samantha Gadd, Stacey L. Raimondi, Tadanori Tomita, Simone Treiger Sredni
Publikováno v:
Bioengineering, Vol 5, Iss 4, p 96 (2018)
Neuroblastoma (NB) is the most common extracranial solid tumor in pediatrics, with rare occurrences of primary and metastatic tumors in the central nervous system (CNS). We previously reported the overexpression of the polo-like kinase 4 (PLK4) in em
Externí odkaz:
https://doaj.org/article/11ff6acefb154c15bbb4c8121a6cac3a