Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tadanori Kumasaka"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 117, Iss 1, Pp 45-53 (2011)
Abstract.: Ecto-5′-nucleotidase (NT5E), a predominant enzyme that produces extracellular adenosine from AMP, plays an important role in a variety of physiological and pathophysiological processes. This study was performed to identify agents that af
Externí odkaz:
https://doaj.org/article/a74f1e9e6ce94d3f994b0e9dfb7f796a
Publikováno v:
Journal of Neurochemistry. 67:398-406
ATP (1 mM) induced a biphasic increase in intracellular Ca2+ concentration ([Ca2+]i), i.e., an initial transient increase decayed to a level of sustained increase, in NG108-15 cells. The transient increase was inhibited by a phospholipase C inhibitor
Autor:
Norimichi Nakahata, Tadanori Kumasaka, Mayumi Rai, Hirobumi Mashiko, Shin-Ichi Niwa, Masatake Kurita, Sou ichi Kouno
Publikováno v:
European Journal of Pharmacology. 442:17-22
Since the therapeutic efficacy of Li+ in the treatment of mood disorder is observed only after chronic administration, we examined whether long-term Li+ treatment with a therapeutic concentration affected the elevation of intracellular-free Ca2+ conc
Autor:
Mayumi Ogata, Shizuko Takano, Tadanori Kumasaka, Hironori Nakanishi, Norimichi Nakahata, Hirobumi Mashiko, Masatake Kurita, Shin-Ichi Niwa
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 27:208-211
1. Histamine H1 receptor-mediated signalling was compared with muscarinic receptor-mediated signalling in 1321N1 human astrocytoma cells. 2. Short-term (2 min) treatment of cells with phorbol 12-myristate 13-acetate (PMA) resulted in a reduction of i
Autor:
Hironori Nakanishi, Tadanori Kumasaka, Hiromi Ishimoto, Satoko Okubo, Isao Matsuoka, Junko Kimura
Publikováno v:
Folia Pharmacologica Japonica. 106:127-131
Extracellular ATP interacts with membrane-bound receptors to induced several physiological functions. The signal transaction pathways associated with the various ATP receptor subtypes have not been fully elucidated. In the present study, we demonstra
Publikováno v:
Folia Pharmacologica Japonica. 106:138-142
ATP at 100 μM induced a trasient [Ca2+]i increase, while at 1 mM it induced the transient increase followed by a sustained [Ca2+]i increase in NG108-15 cells. We examined the mechanism of this sustained [Ca2+] increase using the fura-2 fluorescent m