Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Tadanobu Inaba"'
The comparative interaction of human and bovine serum albumins with CYP2C9 in human liver microsomes
Publikováno v:
Life Sciences. 75:2145-2155
The effect of human serum albumin (HSA), in its endogenous, free fatty acid free (FAF) and globulin free (GF) form, on the activity of CYP2C9 was studied in human liver microsomes using tolbutamide as the substrate. The widely used BSA was included t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f96ff45bb0409392e58e9d512ee373
https://doi.org/10.1016/j.lfs.2004.03.032
https://doi.org/10.1016/j.lfs.2004.03.032
Publikováno v:
Life Sciences. 72:1953-1962
The effects of serum proteins on the in vitro hydroxylation pathways of mephenytoin (CYP2C19) and debrisoquine (CYP2D6) were studied to enhance the predictability of in vivo drug metabolism from in vitro assays. Both CYP substrates are known to be we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2760cad883cc645fde80679b09653659
https://doi.org/10.1016/s0024-3205(03)00093-6
https://doi.org/10.1016/s0024-3205(03)00093-6
Autor:
Isamu Yamamoto, Tadanobu Inaba, Akihiko Sumida, Junichi Azuma, Hideyasu Matsuda, Shuichi Fukuen, Tsuyoshi Fukuda
Publikováno v:
Biochemical and Biophysical Research Communications. 298:433-438
The human pregnane X receptor (hPXR) plays a key role in the regulation of both drug metabolism and efflux by inducing the expression of CYP3A4 and MDR1 gene. Using reverse transcription-polymerase chain reaction (RT-PCR) analysis, we identified seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ef466e8f3566e9087a53506dc943f1
https://doi.org/10.1016/s0006-291x(02)02469-5
https://doi.org/10.1016/s0006-291x(02)02469-5
Autor:
Junichi Azuma, Yuka Ikenaga, Shuichi Fukuen, Isamu Yamamoto, Tadanobu Inaba, Hiromi Maune, Tsuyoshi Fukuda
Publikováno v:
Pharmacogenetics. 12:331-334
In this study, we established useful and reliable methods for the direct detection of the variants of CYP3A5 gene by polymerase chain reaction (PCR) and DdeI restriction analysis. The frequency of CYP3A5 related SNPs in 200 healthy Japanese male subj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9000025d16f0e9cedf5de947e11fd2
https://doi.org/10.1097/00008571-200206000-00009
https://doi.org/10.1097/00008571-200206000-00009
Publikováno v:
Toxicology Letters. 119:219-225
The effect of human serum albumin (HSA), alpha1-acid glycoprotein (alpha1-AGP), and alpha- and gamma-globulins on the in vitro metabolism of debrisoquine in human, hamster and rat liver microsomes was studied. Interaction of albumin with cytochrome P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a7117f58cc146e81b6a5cf912984da
https://doi.org/10.1016/s0378-4274(01)00264-8
https://doi.org/10.1016/s0378-4274(01)00264-8
Autor:
Tadanobu Inaba, Shirin Fayz
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:1654-1658
AZT (zidovudine, 3′-azido-3′-deoxythymidine), although metabolized primarily to AZT-glucuronide, is also metabolized to 3′-amino-3′-deoxythmidine (AMT) by reduction of the azide to an amine. The formation of the myelotoxic metabolite AMT has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5e5b8529c207b05f190b1f78446b23
https://doi.org/10.1128/aac.42.7.1654
https://doi.org/10.1128/aac.42.7.1654
Publikováno v:
Toxicology Letters. 93:215-219
The protease inhibitors, ritonavir, indinavir and saquinavir, the most potent anti-HIV drugs developed to date, interact with many drugs by competing for CYP3A4, an enzyme central to the metabolism of a wide variety of compounds. Human liver microsom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3258ffaa5679c6abb787b961664cb9
https://doi.org/10.1016/s0378-4274(97)00098-2
https://doi.org/10.1016/s0378-4274(97)00098-2
Autor:
Rachel F. Tyndale, Franck Broly, Urs A. Meyer, Werner Kalow, Toshifumi Aoyama, Frank J. Gonzalez, Tadanobu Inaba, Tamihide Matsunaga, Harry V. Gelboin
Publikováno v:
Pharmacogenetics. 1:26-32
A variant CYP2D6(C) P450 protein was found in a liver characterized by deficient microsomal metabolism of bufuralol and sparteine, prototypical substrates for the debrisoquine-sparteine drug oxidation polymorphism. This protein was present at decreas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634e7976cd80e8dc11b5f1563bac9764
https://doi.org/10.1097/00008571-199110000-00005
https://doi.org/10.1097/00008571-199110000-00005
Publikováno v:
Toxicology letters. 136(1)
The effects of human and bovine serum proteins on CYP3A activity, using testosterone as the probe substrate, were investigated in human liver microsomes. Serum albumin, alpha-globulins, and alpha(1)-acid glycoprotein (alpha(1)-AGP) of both species si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b45eb6e3c90f7208710bebbb0171b2
https://pubmed.ncbi.nlm.nih.gov/12368055
https://pubmed.ncbi.nlm.nih.gov/12368055
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 30(6)
1. The major metabolites of rifalazil in human are 25-deacetyl-rifalazil and 32-hydroxy-rifalazil. Biotransformation to these metabolites in pooled human liver microsomes, cytosol and supernatant 9000g (S9) fractions was studied, and the enzymes resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a317fa5a519ab8bb528d7adf343898e6
https://pubmed.ncbi.nlm.nih.gov/10923859
https://pubmed.ncbi.nlm.nih.gov/10923859