Výsledky vyhledávání - "Tadakatsu Nakamura"

Phase 1 Studies to Define the Safety, Tolerability, and Pharmacokinetic and Pharmacodynamic Profiles of the Nonsteroidal Mineralocorticoid Receptor Antagonist Apararenone in Healthy Volunteers

Autor: Tadakatsu Nakamura, Atsuhiro Kawaguchi

Publikováno v: Clinical Pharmacology in Drug Development

Apararenone is a long‐acting, nonsteroidal mineralocorticoid receptor antagonist (MRA). The safety, tolerability, and pharmacokinetic (PK) and pharmacodynamic (PD) profiles of single‐ and multiple‐dose apararenone were assessed in 3 phase 1 ran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7e0d97eee550457bc907fba156240f
http://europepmc.org/articles/PMC8048531

Zobrazit plný text záznamu

Drug–Drug Interactions of the Nonsteroidal Mineralocorticoid Receptor Antagonist Apararenone With Midazolam, Warfarin, and Digoxin: A Phase 1 Studies in Healthy Volunteers

Autor: Tadakatsu Nakamura, Hidetoshi Shimizu, Atsuhiro Kawaguchi

Publikováno v: Clinical Therapeutics. 42:2171-2183.e4

Purpose To characterize the clinical relevance of in vitro drug–drug interaction findings with apararenone (MT-3995), the effects of apararenone on the sensitive substrates of cytochrome P450 3A4 (midazolam) and 2C9 (warfarin), and P-glycoprotein (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6dcce01d5c266ebf367565baec3248
https://doi.org/10.1016/j.clinthera.2020.09.002

Zobrazit plný text záznamu

Clinical pharmacology study of cariprazine (MP-214) in patients with schizophrenia (12-week treatment)

Autor: Tadakatsu Nakamura, Atsushi Iwakaji, Masayoshi Imada, Tomoko Kubota, Yasunori Morio, Margit Kapás

Publikováno v: Drug Design, Development and Therapy

Tadakatsu Nakamura,1 Tomoko Kubota,1 Atsushi Iwakaji,1 Masayoshi Imada,1 Margit Kapás,2 Yasunori Morio1 1Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan; 2Developmental Drug Metabolism and Pharmacokinetics,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cb084b8190abff12e9dbf41336688c
https://www.dovepress.com/clinical-pharmacology-study-of-cariprazine-mp-214-in-patients-with-sch-peer-reviewed-article-DDDT

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání