Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Tadahiro Nakamura"'
Autor:
Yukinobu Kodama, Ayako Tokunaga, Junya Hashizume, Hiroo Nakagawa, Hitomi Harasawa, Tomoaki Kurosaki, Tadahiro Nakamura, Koyo Nishida, Mikiro Nakashima, Mitsuru Hashida, Shigeru Kawakami, Hitoshi Sasaki
Publikováno v:
Drug Delivery, Vol 28, Iss 1, Pp 542-549 (2021)
We developed a biocompatible splenic vector for a DNA vaccine against melanoma. The splenic vector is a ternary complex composed of plasmid DNA (pDNA), biodegradable dendrigraft poly-L-lysine (DGL), and γ-polyglutamic acid (γ-PGA), the selective up
Externí odkaz:
https://doaj.org/article/fb4c978fa3e54f91a147d0e487eba2de
Autor:
Tomoaki Kurosaki, Yuki Katafuchi, Junya Hashizume, Hitomi Harasawa, Hiroo Nakagawa, Mikiro Nakashima, Tadahiro Nakamura, Chikamasa Yamashita, Hitoshi Sasaki, Yukinobu Kodama
Publikováno v:
Drug Delivery, Vol 28, Iss 1, Pp 1585-1593 (2021)
We previously found that a nanoparticle constructed with an antigen, benzalkonium chloride (BK) and γ-polyglutamic acid (γ-PGA) showed high Th1 and Th2-type immune induction after subcutaneous administration. For prophylaxis of respiratory infectio
Externí odkaz:
https://doaj.org/article/1ae04cee4a2a4aa4a42fa110b05051e5
Autor:
Tomoaki Kurosaki, Hiroki Kanda, Junya Hashizume, Kayoko Sato, Hitomi Harasawa, Tadahiro Nakamura, Hitoshi Sasaki, Yukinobu Kodama
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1983 (2021)
In a previous study, we constructed a lung-targeting lipopolyplex containing polyethyleneimine (PEI), 1,2-di-O-octadecenyl-3-trimethylammonium propane (DOTMA), and N-lauroylsarcosine (LS). The lipopolyplex exhibited an extremely high gene expression
Externí odkaz:
https://doaj.org/article/0208892e048c44ed97c76acfa0360944
Autor:
Eri Hamada, Tomoaki Kurosaki, Junya Hashizume, Hitomi Harasawa, Hiroo Nakagawa, Tadahiro Nakamura, Yukinobu Kodama, Hitoshi Sasaki
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 126 (2021)
We previously found that a complex comprising plasmid DNA (pDNA), polyethylenimine (PEI), and γ-polyglutamic acid (γ-PGA) had high transgene efficiency without cytotoxicity in vitro and in vivo. However, messenger RNA (mRNA) remains an attractive a
Externí odkaz:
https://doaj.org/article/c3a9ead85c6e4ecdba2438dae4bf38bf
Autor:
Yukinobu Kodama, Mikiro Nakashima, Tadayuki Nagahara, Natsuko Oyama, Junya Hashizume, Hiroo Nakagawa, Hitomi Harasawa, Takahiro Muro, Tomoaki Kurosaki, Chikamasa Yamashita, Mitsuru Hashida, Takashi Kitahara, Hitoshi Sasaki, Shigeru Kawakami, Tadahiro Nakamura
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 540 (2020)
The present study investigated a pulmonary delivery system of plasmid DNA (pDNA) and its application to melanoma DNA vaccines. pCMV-Luc, pEGFP-C1, and pZsGreen were used as a model pDNA to evaluate transfection efficacy after inhalation in mice. Nake
Externí odkaz:
https://doaj.org/article/ccca79c866d4453b80411a0836bdca55
Autor:
Tomoaki Kurosaki, Takashi Kitahara, Shintaro Fumoto, Koyo Nishida, Kayo Yamamoto, Hiroo Nakagawa, Yukinobu Kodama, Norihide Higuchi, Tadahiro Nakamura, Hitoshi Sasaki
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 13, Iss 3 (2010)
Purpose. In this study, we developed various ternary complexes of encapsulated polyplexes and lipoplexes using chondroitin sulfate (CS) and investigated their universal usefulness for gene delivery. Methods. To prepare the cationic complexes, pDNA wa
Externí odkaz:
https://doaj.org/article/32c25b7db4a64fc5bf2ef82528e31d41
Autor:
Asako Doi, Kentaro Iwata, Tadahiro Nakamura, Koji Oh, Kenichi Isome, Kohei Hasegawa, Hirokazu Kuroda, Toshikazu Hasuike, Ryutaro Seo, Hisato Kosai, Noriko Nakanishi, Ryohei Nomoto, Riyo Fujiyama, Nobuya Kusunoki, Tomotada Iwamoto, Hiroaki Nishioka, Keisuke Tomii, Yasuki Kihara
Publikováno v:
Journal of Infection and Chemotherapy. 29:289-293
The emergence of the Alpha variant of novel coronavirus 2019 (SARS-CoV-2) is a concerning issue but their clinical implications have not been investigated fully.We conducted a nested case-control study to compare severity and mortality caused by the
Autor:
Yuki Kawauchi, Kyoko Hasegawa, Haruna Yamashita, Tadahiro Nakamura, Yukinobu Kodama, Junya Hashizume, Nozomi Ezaki, Hitoshi Sasaki, Emi Ryu, Koji Ishii, Kyohei Shiojiri, Hitomi Harasawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1081-1087
Naldemedine (NAL), a peripherally acting μ-opioid receptor antagonist, is effective for opioid-induced constipation (OIC). However, diarrhea is the most common adverse event. We investigated the incidence of NAL-induced diarrhea in patients who star
Autor:
Junya Hashizume, Megumi Matsumoto, Hiroshi Yano, Ryota Otsubo, Ayako Fukushima, Kayoko Sato, Hiroo Nakagawa, Hitomi Harasawa, Tadahiro Nakamura, Hitoshi Sasaki, Takeshi Nagayasu, Yukinobu Kodama
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 47:217-224
Autor:
Yuki Katafuchi, Junya Hashizume, Hiroo Nakagawa, Tomoaki Kurosaki, Yukinobu Kodama, Chikamasa Yamashita, Mikiro Nakashima, Hitomi Harasawa, Hitoshi Sasaki, Tadahiro Nakamura
Publikováno v:
Drug Delivery, Vol 28, Iss 1, Pp 1585-1593 (2021)
Drug Delivery
article-version (VoR) Version of Record
Drug Delivery
article-version (VoR) Version of Record
We previously found that a nanoparticle constructed with an antigen, benzalkonium chloride (BK) and γ-polyglutamic acid (γ-PGA) showed high Th1 and Th2-type immune induction after subcutaneous administration. For prophylaxis of respiratory infectio