Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Tadahiro Iimura"'
Autor:
Ji-Won Lee, Kaito Mizuno, Haruhisa Watanabe, In-Hee Lee, Takuya Tsumita, Kyoko Hida, Yasutaka Yawaka, Yoshimasa Kitagawa, Akira Hasebe, Tadahiro Iimura, Sek Won Kong
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Multinucleated microglia have been observed in contexts associated with infection, inflammation, and aging. Though commonly linked to pathological conditions, the larger cell size of multinucleated microglia might enhance their phagocytic fu
Externí odkaz:
https://doaj.org/article/42390726e32e40f7b382cf7f7dcc8d93
Autor:
Mana Hashimoto, Haruka Takahashi, Kaori Tabata-Okubo, Noriyuki Nagaoka, Kazuaki Tokunaga, Haruka Matsumori, Yoshihito Ishihara, Masaru Kaku, Tadahiro Iimura, Toru Hara, Hiroshi Kamioka
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Osteocytes form a cellular network by gap junctions between their cell processes. This network is important since intercellular communication via the network is essential for bone metabolism. However, the factors that influence the formation
Externí odkaz:
https://doaj.org/article/55c87e6466734c02a254dd03ec7b8c32
Autor:
Ji-Won Lee, In-Hee Lee, Haruhisa Watanabe, Yunqing Liu, Kazuaki Sawada, Masashi Maekawa, Shunsuke Uehara, Yasuhiro Kobayashi, Yuuki Imai, Sek Won Kong, Tadahiro Iimura
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Osteoclasts uniquely resorb calcified bone matrices. To exert their function, mature osteoclasts maintain the cellular polarity and directional vesicle trafficking to and from the resorbing bone surface. However, the regulatory mechanisms an
Externí odkaz:
https://doaj.org/article/dccf3fbc05964da5941a3b4688ff3648
Autor:
Marie Hoshi-Numahata, Aya Takakura, Atsuko Nakanishi-Kimura, Haruhisa Watanabe, Kentaro Takada, Mai Nishiura, Yoshiaki Sato, Ryoko Takao-Kawabata, Tadahiro Iimura
Publikováno v:
Bone Reports, Vol 19, Iss , Pp 101720- (2023)
Larger animal models with a well-developed Haversian system, as observed in humans, are ideal to analyze cortical bone remodeling in pharmacological studies of anti-osteoporosis drugs, although they have some limitations in controlling individual var
Externí odkaz:
https://doaj.org/article/eb7c927de2464104b88416cc21ea87e8
Autor:
Aya Takakura, Takanori Sato, Ji-Won Lee, Kyoko Hirano, Ryoko Takao-Kawabata, Toshinori Ishizuya, Tadahiro Iimura
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Osteoporosis is an age-related disorder that is characterized by reduced bone mass. Its prevention and treatment are important healthcare issues for maintaining social activity in aged societies. Although bone fractures mostly occur at sites
Externí odkaz:
https://doaj.org/article/26a36f230a114b65a2247292a81b70cf
Autor:
Rika Numano, Akihiro Goryu, Yoshihiro Kubota, Hirohito Sawahata, Shota Yamagiwa, Minako Matsuo, Tadahiro Iimura, Hajime Tei, Makoto Ishida, Takeshi Kawano
Publikováno v:
FEBS Open Bio, Vol 12, Iss 4, Pp 835-851 (2022)
Genetic modification to restore cell functions in the brain can be performed through the delivery of biomolecules in a minimally invasive manner into live neuronal cells within brain tissues. However, conventional nanoscale needles are too short (len
Externí odkaz:
https://doaj.org/article/8904ddec34774351bd08e76161145020
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-10 (2021)
Abstract Tissue-resident macrophages are highly specialized to their tissue-specific microenvironments, activated by various inflammatory signals and modulated by genetic and environmental factors. Osteoclasts and microglia are distinct tissue-reside
Externí odkaz:
https://doaj.org/article/9ebdacaa3b454f7c9db35929423236f8
Autor:
Eriko Hamasaki, Natsuki Wakita, Hiroki Yasuoka, Hikaru Nagaoka, Masayuki Morita, Eizo Takashima, Takayuki Uchihashi, Tetsuya Takeda, Tadashi Abe, Ji-Won Lee, Tadahiro Iimura, Moin A Saleem, Naohisa Ogo, Akira Asai, Akihiro Narita, Kohji Takei, Hiroshi Yamada
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Dynamin is an endocytic protein that functions in vesicle formation by scission of invaginated membranes. Dynamin maintains the structure of foot processes in glomerular podocytes by directly and indirectly interacting with actin filaments. However,
Externí odkaz:
https://doaj.org/article/d8d684637941406b9a5dac408770ee49
Autor:
Ji-Won Lee, Akiyoshi Hoshino, Kazuki Inoue, Takashi Saitou, Shunsuke Uehara, Yasuhiro Kobayashi, Satoshi Ueha, Kouji Matsushima, Akira Yamaguchi, Yuuki Imai, Tadahiro Iimura
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
CCR5 is a co-receptor for HIV, and loss of function is associated with lower incidence of HIV but also with bone-destructive diseases. Here the authors show that ablation of CCR5 impairs osteoclast function and improves resistance to osteoporosis in
Externí odkaz:
https://doaj.org/article/6fe7e4dd266040a8baeee5dab56aa280
Publikováno v:
Japanese Dental Science Review, Vol 53, Iss 1, Pp 2-10 (2017)
Digitalized fluorescence images contain numerical information such as color (wavelength), fluorescence intensity and spatial position. However, quantitative analyses of acquired data and their validation remained to be established. Our research group
Externí odkaz:
https://doaj.org/article/ab5af77d4efe4a0fba04fe109ecb3511