Výsledky vyhledávání - "Tadahiro Fujino"

PCCX1, a Novel DNA-Binding Protein with PHD Finger and CXXC Domain, Is Regulated by Proteolysis

Autor: Mayumi Hasegawa, Toshiya Takano, Shinsuke Shibata, Shin-ichiro Imai, Taishiro Kishimoto, Tadahiro Fujino

Publikováno v: Biochemical and Biophysical Research Communications. 271:305-310

We identified a novel gene PCCX1 that encoded a nuclear protein carrying a PHD finger, a CXXC domain, and an acidic region. The CXXC domain was found to be sufficient for binding to DNA. The acidic region exhibited a high transactivation ability, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3153f821d360cd057632979e8c0368
https://doi.org/10.1006/bbrc.2000.2614

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Immortalization-Susceptible Elements and Their Binding Factors Mediate Rejuvenation of Regulation of the Type I Collagenase Gene in Simian Virus 40 Large T Antigen-Transformed Immortal Human Fibroblasts

Autor: Shin-ichiro Imai, Tomohiro Manabe, Toshiya Takano, Seiji Nishibayashi, Tadahiro Fujino

Publikováno v: Molecular and Cellular Biology. 14:7182-7194

Dramatic changes occur in expression of the type I collagenase gene during the process of immortalization in simian virus 40 large T antigen-transformed human fibroblasts (S. Imai and T. Takano, Biochem. Biophys. Res. Commun. 189:148-153, 1992). From

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5094d339b4d323c3865eb4605d7e9694
https://doi.org/10.1128/mcb.14.11.7182-7194.1994

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CPG15 regulates synapse stability in the developing and adult brain

Autor: Genevieve H. Flanders, Elly Nedivi, Tadahiro Fujino, Jennifer H. Leslie, Erzsebet Borok, Tamas L. Horvath, Ronen Eavri, Jerry L. Chen, Walter C. Lin

Publikováno v: PMC

Use-dependent selection of optimal connections is a key feature of neural circuit development and, in the mature brain, underlies functional adaptation, such as is required for learning and memory. Activity patterns guide circuit refinement through s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c84fe7de6c64cd1a74c3fbd9f580b21d
https://orcid.org/0000-0002-1710-0767

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cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival

Autor: Tadahiro Fujino, Elly Nedivi, Zhen Wu, Marnie A. Phillips, Walter C. Lin

Publikováno v: The Journal of comparative neurology. 507(5)

Many ligands that affect nervous system development are members of gene families that function together to coordinate the assembly of complex neural circuits. cpg15/neuritin encodes an extracellular ligand that promotes neurite growth, neuronal survi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a21d7dce2d7e72bf75996d4d1168674
https://pubmed.ncbi.nlm.nih.gov/18265009

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Regulation of cpg15 by signaling pathways that mediate synaptic plasticity

Autor: Elly Nedivi, Wei-Chung Allen Lee, Tadahiro Fujino

Publikováno v: Molecular and cellular neurosciences. 24(3)

Transcriptional activation is a key link between neuronal activity and long-term synaptic plasticity. Little is known about genes responding to this activation whose products directly effect functional and structural changes at the synapse. cpg15 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59064ef4df4415050fc78dcb6d01e16
https://pubmed.ncbi.nlm.nih.gov/14664806

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Effect of intra-ischemic hypothermia on the expression of c-Fos and c-Jun, and DNA binding activity of AP-1 after focal cerebral ischemia in rat brain

Autor: Kazunori Akaji, Shuzo Sato, Sadao Suga, Tadahiro Fujino, Takashi Horiguchi, Joji Inamasu, Keita Mayanagi, Takeshi Kawase

Publikováno v: Brain research. 975(1-2)

It is unknown whether immediate early gene (IEG) induction and subsequent late gene regulation after ischemia is beneficial or deleterious. The aim of this study was to examine the effect of hypothermia on expression of c-Fos and c-Jun, and AP-1 DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba63f29f5f6f69ebe50f3b91e45b52a3
https://pubmed.ncbi.nlm.nih.gov/12763603

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Dissociation of Oct-1 from the nuclear peripheral structure induces the cellular aging-associated collagenase gene expression

Autor: Seiji Nishibayashi, Koji Takao, Shin-ichiro Imai, Masayuki Tomifuji, Tadahiro Fujino, Toshiya Takano, Mayumi Hasegawa

Publikováno v: Molecular biology of the cell. 8(12)

The cellular aging-associated transcriptional repressor that we previously named as Orpheus was identical to Oct-1, a member of the POU domain family. Oct-1 represses the collagenase gene, one of the cellular aging-associated genes, by interacting wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70879666522bc43ab1d40fab71c13345
https://pubmed.ncbi.nlm.nih.gov/9398664

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A phase I study of intravenous aflibercept with FOLFIRI in Japanese patients with previously treated metastatic colorectal cancer

Autor: Tadahiro Fujino, Atsushi Ohtsu, Nozomu Machida, Yusuke Onozawa, Kentaro Yamazaki, Masako Asayama, Narikazu Boku, Toshihiko Doi, Kensei Yamaguchi, Takayuki Yoshino

Publikováno v: Investigational New Drugs

Summary Aflibercept, a recombinant fusion protein, is a potent inhibitor of vascular endothelial growth factor (VEGF)-A, VEGF-B, and the placental growth factor (PlGF). The present study was an open-label, sequential-cohort, dose-escalation trial of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722586e9223017b54edc47f7e2580663

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