Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Tadafumi Hashimoto"'
Publikováno v:
International Journal of Automotive Engineering, Vol 14, Iss 3, Pp 77-83 (2023)
In this study, a computer simulation technique is developed for numerically predicting the residual stress relaxation caused by bending-straightening in quenching-induction-hardened axle shafts. Both the strength and residual stress distributions ins
Externí odkaz:
https://doaj.org/article/17ec6d7f61df44618614c8f529a44002
Autor:
Nanaka Kaneshiro, Masato Komai, Ryosuke Imaoka, Atsuya Ikeda, Yuji Kamikubo, Takashi Saito, Takaomi C. Saido, Taisuke Tomita, Tadafumi Hashimoto, Takeshi Iwatsubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103869- (2022)
Summary: Endosomal anomalies because of vesicular traffic impairment have been indicated as an early pathology of Alzheimer’| disease (AD). However, the mechanisms and therapeutic targets remain unclear. We previously reported that βCTF, one of th
Externí odkaz:
https://doaj.org/article/124f74c73d5442159b8dfea2961c3d7f
Autor:
Tadafumi Hashimoto, Daisuke Fujii, Yasushi Naka, Mayu Kashiwagi-Hakozaki, Yuko Matsuo, Yusuke Matsuura, Tomoko Wakabayashi, Takeshi Iwatsubo
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-18 (2020)
Abstract Massive deposition of amyloid β peptides (Aβ) as senile plaques (SP) characterizes the brain pathology of Alzheimer’s disease (AD). SPs exhibit a variety of morphologies, although little is known about the SP components that determine th
Externí odkaz:
https://doaj.org/article/f30fc230e2c14ed3b0912241e753772d
Autor:
Haiyan An, Gioana Litscher, Naruaki Watanabe, Wenbin Wei, Tadafumi Hashimoto, Takeshi Iwatsubo, Vladimir L. Buchman, Tatyana A. Shelkovnikova
Publikováno v:
Neurobiology of Disease, Vol 162, Iss , Pp 105585- (2022)
Formation of cytoplasmic RNA-protein structures called stress granules (SGs) is a highly conserved cellular response to stress. Abnormal metabolism of SGs may contribute to the pathogenesis of (neuro)degenerative diseases such as amyotrophic lateral
Externí odkaz:
https://doaj.org/article/5d63137f0a32465ab65af9032e87e214
Autor:
Yoichiro Abe, Natsumi Ikegawa, Keitaro Yoshida, Kyosuke Muramatsu, Satoko Hattori, Kenji Kawai, Minetaka Murakami, Takumi Tanaka, Wakami Goda, Motohito Goto, Taichi Yamamoto, Tadafumi Hashimoto, Kaoru Yamada, Terumasa Shibata, Hidemi Misawa, Masaru Mimura, Kenji F. Tanaka, Tsuyoshi Miyakawa, Takeshi Iwatsubo, Jun-ichi Hata, Takako Niikura, Masato Yasui
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-15 (2020)
Abstract Aquaporin-4 (AQP4) has been suggested to be involved in the pathogenesis of neurodegenerative diseases including Alzheimer’s disease (AD), which may be due to the modulation of neuroinflammation or the impairment of interstitial fluid bulk
Externí odkaz:
https://doaj.org/article/1c8558c64520446089d7b86f40ae3269
Autor:
Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko Matsuo, Naoto Kubota, Takashi Kadowaki, Takeshi Iwatsubo
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-18 (2019)
Abstract Background Based on epidemiological and experimental studies, type 2 diabetes mellitus (T2DM), especially insulin resistance that comprises the core mechanism of T2DM, has been recognized as a significant risk factor for Alzheimer’s diseas
Externí odkaz:
https://doaj.org/article/5c9873e539af42909939d09c0139f91b
Autor:
Haruka Munezane, Hiroaki Oizumi, Tomoko Wakabayashi, Shu Nishio, Tomoko Hirasawa, Takashi Sato, Akihiro Harada, Tomoyuki Yoshida, Takahiro Eguchi, Yuji Yamanashi, Tadafumi Hashimoto, Takeshi Iwatsubo
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4362-4376.e6 (2019)
Summary: Intramuscular motor innervation is an essential process in neuromuscular development. Recently, mutations in COL25A1, encoding CLAC-P/collagen XXV, have been linked to the development of a congenital cranial dysinnervation disorder (CCDD). Y
Externí odkaz:
https://doaj.org/article/9f7b9257524b4cf0896c2cc86be8f09d
Autor:
Sangeun Park, Sei-Kyoung Park, Naruaki Watanabe, Tadafumi Hashimoto, Takeshi Iwatsubo, Tatyana A Shelkovnikova, Susan W Liebman
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008308 (2019)
Proteins associated with familial neurodegenerative disease often aggregate in patients' neurons. Several such proteins, e.g. TDP-43, aggregate and are toxic when expressed in yeast. Deletion of the ATXN2 ortholog, PBP1, reduces yeast TDP-43 toxicity
Externí odkaz:
https://doaj.org/article/715c39ae19a3469ab13eac20d342bec5
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219465 (2019)
Accumulation of amyloid ß (Aß) peptides, the major component of amyloid fibrils in senile plaques, is one of the main causes of Alzheimer's disease. Docosahexaenoic acid (DHA) is a fatty acid abundant in the brain, and is reported to have protectiv
Externí odkaz:
https://doaj.org/article/d429c936195d4518b3a717bd699bcc2e
Autor:
Kaoru Yamamoto, Zen-ichi Tanei, Tadafumi Hashimoto, Tomoko Wakabayashi, Hiroyuki Okuno, Yasushi Naka, Ofer Yizhar, Lief E. Fenno, Masashi Fukayama, Haruhiko Bito, John R. Cirrito, David M. Holtzman, Karl Deisseroth, Takeshi Iwatsubo
Publikováno v:
Cell Reports, Vol 11, Iss 6, Pp 859-865 (2015)
In vivo experimental evidence indicates that acute neuronal activation increases Aβ release from presynaptic terminals, whereas long-term effects of chronic synaptic activation on Aβ pathology remain unclear. To address this issue, we adopted optog
Externí odkaz:
https://doaj.org/article/735a025e6b604e8cb7fe218382bd6e3a