Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma.

Autor: Naoshi Nishida, Masatoshi Kudo, Takafumi Nishimura, Tadaaki Arizumi, Masahiro Takita, Satoshi Kitai, Norihisa Yada, Satoru Hagiwara, Tatsuo Inoue, Yasunori Minami, Kazuomi Ueshima, Toshiharu Sakurai, Naosuke Yokomichi, Takeshi Nagasaka, Ajay Goel

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e72312 (2013)

Global DNA hypomethylation is a characteristic feature of cancer cells that closely associates with chromosomal instability (CIN). However, the association between these characteristics during hepatocarcinogenesis remains unclear. Herein, we determin

Externí odkaz: https://doaj.org/article/6147168e24e147ae821b2defde2d8d5e

Gankyrin induces STAT 3 activation in tumor microenvironment and sorafenib resistance in hepatocellular carcinoma

Autor: Mamoru Takenaka, Tadaaki Arizumi, Tomohiro Watanabe, Satoru Hagiwara, Kosuke Minaga, Ken Kamata, Norihisa Yada, Masatoshi Kudo, Toshiharu Sakurai, Naoshi Nishida, Yasunori Minami

Publikováno v: Cancer Science

Most hepatocellular carcinomas (HCCs) develop as a result of chronic liver inflammation. We have shown that the oncoprotein gankyrin is critical for inflammation-induced tumourigenesis in the colon. Although the in vitro function of gankyrin is well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c39c33292700b4dfc96f85bef766805
https://doi.org/10.1111/cas.13341

The albumin-bilirubin grade improves hepatic reserve estimation post-sorafenib failure: implications for drug development

Autor: C. Yen, Robert Thimme, Caroline Ward, Ramya Ramaswami, Mario Pirisi, Rohini Sharma, David J. Pinato, Tadaaki Arizumi, Dominik Bettinger, Masatoshi Kudo, Michela Emma Burlone

Publikováno v: Alimentary Pharmacology & Therapeutics. 45:714-722

SummaryBackground Drug development in hepatocellular carcinoma (HCC) is limited by disease heterogeneity, with hepatic reserve being a major source of variation in survival outcomes. The albumin–bilirubin (ALBI) grade is a validated index of liver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa109b28ce7eb6a5a0cac0372fcceaf8
https://doi.org/10.1111/apt.13904

Contents Vol. 35, 2017

Autor: Hobyung Chung, Midori Ando, Takanori Ito, Kayo Seo, Toshiharu Sakurai, Yujiro Nozawa, Natsuko Kobayashi, Toshifumi Tada, Aya Ohtani, Ryuichiro Iwasaki, Soo Ki Kim, Yasuharu Imai, Tomonari Okudaira, Noritomo Shimada, Etsuko Iio, Keiichi Seki, Osamu Nakashima, Ken Kamata, Tadaaki Arizumi, Tomohiro Watanabe, Koji Joko, Hirofumi Izumoto, Michitaka Imai, Hiroshi Ida, Kenichi Harada, Yuka Saijo, Takayuki Iwamoto, Tomohiro Minami, Mamoru Takenaka, Takeshi Okanoue, Akito Iwanaga, Yasuko Umehara, Akemi Tsutsui, Shigeya Hirohata, Yoshitake Hayashi, Takashi Owaki, Shogo Kitahata, Eiji Tsubouchi, Hirokazu Chishina, Soo Ryang Kim, Osakuni Morimoto, Aya Fujinami, Chi Wan Kim, Miho Kaneto, Taisei Murakami, Ke Ih Kim, Koichi Takaguchi, Nobuhura Tamaki, Norihiko Fujita, Yasuhito Tanaka, Yoriaki Komeda, Tomoyuki Ninomiya, Masatoshi Kudo, Tetsuo Takehara, Takashi Kumada, Masashi Kono, Kunihiko Tsuji, Hiroki Sato, Sachiyo Kogita, Susumu Imoto, Hidenori Toyoda, Kazuto Fukuda, Mana Kobayashi, Kazuomi Ueshima, Seitetsu Yoon, Masayoshi Kage, Takumi Igura, Satoko Nakamura, Naoshi Nishida, Shinji Katsushima, Masato Kishida, Atsushi Hiraoka, Toru Ishikawa, Satoru Hagiwara, Takuya Nagano, Kosuke Minaga, Druckerei Stückle, Koichi Mizobuchi, Hidetaro Ueki, Kazuto Tajiri, Akihiro Deguchi, Yoshiyuki Sawai, Terasu Honma, Hironori Ochi, Masahiro Takita, Hideomi Tomida, Eri Morimoto, Hiroyuki Kokuryu, Masanori Nakahara, Keisuke Amano, Toshiaki Yoshida, Marie Ochi, Toyokazu Fukunaga, Yasushi Matsumoto, Tomonori Senoh, Yuji Miyamoto, Masashi Hirooka, Hideki Miyata, Toshiki Komeda, Takashi Hatae, Koichi Tsuneyama, Hiroka Yamago, Kenichiro Mori, Yoichi Hiasa, Airi Kato, Yoshitaka Yamaguchi, Yohei Koizumi, Tomoe Sano, Kojiro Michitaka, Hiroshi Ohashi, Yasunori Minami, Norihisa Yada, Toshihiko Aibiki, Namiki Izumi, Yutaka Horie, Yoshihiko Yano

Publikováno v: Digestive Diseases. 35:I-VIII

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc0dbb8fe9819876d7fe2158feab8798
https://doi.org/10.1159/000481550

Characterization of Pancreatic Tumors with Quantitative Perfusion Analysis in Contrast-Enhanced Harmonic Endoscopic Ultrasonography

Autor: Masatoshi Kudo, Shunsuke Omoto, Mamoru Takenaka, Yogesh Harwani, Takeshi Miyata, Hiroki Sakamoto, Hajime Imai, Ken Kamata, Naoshi Nishida, Toshiharu Sakurai, Kosuke Minaga, Yoshifumi Takeyama, Kentaro Yamao, Yasutaka Chiba, Tadaaki Arizumi, Tomohiro Watanabe, Masayuki Kitano

Publikováno v: Oncology. 93:55-60

Objectives: This study evaluated whether quantitative perfusion analysis with contrast-enhanced harmonic (CH) endoscopic ultrasonography (EUS) characterizes pancreatic tumors, and compared the hemodynamic parameters used to diagnose pancreatic carcin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b237de3965c718904a8700e43f2b729d
https://doi.org/10.1159/000481231