Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tad Kornaga"'
Autor:
Melissa L. Geddie, Dmitri B. Kirpotin, Neeraj Kohli, Tad Kornaga, Bjoern Boll, Maja Razlog, Daryl C. Drummond, Alexey A. Lugovskoy
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Antibody-directed nanotherapeutics (ADNs) represent a promising delivery platform for selective delivery of an encapsulated drug payload to the site of disease that improves the therapeutic index. Although both single-chain Fv (scFv) and Fab antibody
Externí odkaz:
https://doaj.org/article/9d2891dc79f643129c3b3b205c1860ca
Autor:
Lia Luus, Vasileios Askoxylakis, John Wilton, Alexey Lugovskoy, Kenneth J. Olivier, Stephanie Grabow, Jaeyeon Kim, Christine Pien, Geoffrey Kuesters, Suresh K. Tipparaju, Melissa Geddie, Nancy Dumont, Mark E. Hayes, Alexander Koshkaryev, Sarah A Schihl, C. Patrick Reynolds, Rachel Blaydes, Andrew J. Sawyer, James D. Marks, Tad Kornaga, James Suchy, Charles O. Noble, Dmitri B. Kirpotin, Shinji Oyama, Neeraj Kohli, Zhaohua Richard Huang, Walid S. Kamoun, Daryl C. Drummond, Yu Zhou
Publikováno v:
Nature Biomedical Engineering. 3:264-280
Antibody-mediated tumour targeting and nanoparticle-mediated encapsulation can reduce the toxicity of antitumour drugs and improve their efficacy. Here, we describe the performance of a nanotherapeutic encapsulating a hydrolytically sensitive docetax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8e94f819de7e7f6ccdf49b01d0fee2
https://doi.org/10.1038/s41551-019-0385-4
https://doi.org/10.1038/s41551-019-0385-4
Autor:
Suresh K. Tipparaju, Charles O. Noble, Alexander Koshkaryev, Walid S. Kamoun, Jimmy Tran, Tad Kornaga, Daryl C. Drummond, Zhaohua Richard Huang, Christine Pien, Dmitri B. Kirpotin
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 310
Ephrin A2 targeted immunoliposomes incorporating pH-sensitive taxane prodrugs were developed for sustained delivery of active drug to solid tumors. Here we describe the systematic formulation development and characterization of these immunoliposomes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8518d6c9b5dbb65c54db1d72e289f2ed
https://pubmed.ncbi.nlm.nih.gov/31400383
https://pubmed.ncbi.nlm.nih.gov/31400383
Autor:
Ulrik B. Nielsen, Lihui Xu, Kathy Zhang, Daryl C. Drummond, Tad Kornaga, Alexey Lugovskoy, Neeraj Kohli, Yang Jiao, Melissa Geddie, Dmitri B. Kirpotin, Rachel Rennard
Publikováno v:
mAbs. 7:42-52
Antibody-targeted nanoparticles have the potential to significantly increase the therapeutic index of cytotoxic anti-cancer therapies by directing them to tumor cells. Using antibodies or their fragments requires careful engineering because multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6a382dc09e32673b428ce1ff29a329
https://doi.org/10.4161/19420862.2014.985933
https://doi.org/10.4161/19420862.2014.985933
Autor:
Alexey Lugovskoy, Rachel Rennard, Dmitri B. Kirpotin, Melissa Geddie, Tad Kornaga, Birgit Schoerberl, James D. Marks, Maja Razlog, Lihui Xu, Neeraj Kohli, Yang Jiao, Daryl C. Drummond
Publikováno v:
mAbs, vol 9, iss 1
Antibody-targeted nanoparticles have great promise as anti-cancer drugs; however, substantial developmental challenges of antibody modules prevent many candidates from reaching the clinic. Here, we describe a robust strategy for developing an EphA2-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa91df438843b3da3c3a9876275130f
https://escholarship.org/uc/item/1z81p181
https://escholarship.org/uc/item/1z81p181
Autor:
Alexander Koshkaryev, Walid S. Kamoun, Birgit Schoeberl, Zhaohua Richard Huang, James D. Marks, Kenneth R. Olivier, Christine S. Pien, Tad Kornaga, Daryl C. Drummond, Gerald J. Fetterly, Dmitri B. Kirpotin, Charles O. Noble, Suresh K. Tipparaju, Shinji Oyama, Sarah S. Schihl, Mark E. Hayes
Publikováno v:
Cancer Research. 76:3912-3912
Taxanes are widely used to treat solid tumors either in the curative or palliative setting, in first or later lines of therapy. Analysis of docetaxel dose-response relationship strongly suggests that a higher dose would lead to high response, however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f364e758686b143203440947d8c885
https://doi.org/10.1158/1538-7445.am2016-3912
https://doi.org/10.1158/1538-7445.am2016-3912
Autor:
Walid S. Kamoun, Tad Kornaga, Stephan G. Klinz, Daryl C. Drummond, Sarah Blanchette, Alexander Koshkaryev, Ashish Kalra, Jonathan Fitzgerald, Jaeyeon Kim, Lia Luus, Susan E. Bates, Ozan Alkan, Yves Pommier
Publikováno v:
Cancer Research. 76:2075-2075
PARPs (poly ADP ribose polymerases) are a family of enzymes involved in DNA repair via two mechanisms: catalytic inhibition and trapping of PARP-DNA complexes. Inhibition of this repair pathway can result in cell death following DNA damage. Irinoteca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c00ca49653d86fa5b433f935a050026
https://doi.org/10.1158/1538-7445.am2016-2075
https://doi.org/10.1158/1538-7445.am2016-2075
Autor:
Dmitri B. Kirpotin, Lia Luus, Walid S. Kamoun, Tad Kornaga, Daryl C. Drummond, James D. Marks, Alexey Lugovskoy, Minh T. Pham, Lihui Xu, Shinji Oyama, Carl Morrisson, Theresa Feng, Melissa Geddie, Monica L. Murphy
Publikováno v:
Cancer Research. 76:750-750
Ephrin receptor A2 (EphA2) is part of the Ephrin family of cell-cell junction proteins highly overexpressed in several solid tumors, and is associated with poor prognosis. We developed a novel EphA2-targeted docetaxel nanoliposome, leveraging organ s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3de78fa94d27db26ae718546b41b7dcc
https://doi.org/10.1158/1538-7445.am2016-750
https://doi.org/10.1158/1538-7445.am2016-750
Autor:
Lihui Xu, James D. Marks, Alexander Koshkaryev, Walid S. Kamoun, Alexey Lugovosky, Zhaohua Richard Huang, Christine S. Pien, Dmitri B. Kirpotin, Melissa Geddie, Suresh K. Tipparaju, Shinji Oyama, Lia Luus, Tad Kornaga, Daryl C. Drummond
Publikováno v:
Cancer Research. 76:871-871
Ephrins receptors are cell to cell adhesion molecules that mediate signaling and are implicated in neuronal repulsion, cell migration and angiogenesis. Ephrin receptor A2 (EphA2) is part of the ephrin family and was shown to be overexpressed in sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd7e57a4fdffe31ddc2f0ae70608918f
https://doi.org/10.1158/1538-7445.am2016-871
https://doi.org/10.1158/1538-7445.am2016-871
Autor:
Talia Dor, J. Nalinee Upalakalin, Ichiro Shiojima, Thuy L. Phung, Dian Feng, Tad Kornaga, Laura E. Benjamin, Terri Felske, Kenneth Walsh, Jing Fang Sun, Ann M. Dvorak
Publikováno v:
Proceedings of the National Academy of Sciences. 102:128-133
We investigated the functions of Akt during vascular development and remodeling by using an inducible endothelial cell-specific driver of the dominant-active myrAkt. We found that sustained signaling in response to overexpression of myrAkt led to emb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b62f0397617d3aae8df50641ef54416
https://doi.org/10.1073/pnas.0403198102
https://doi.org/10.1073/pnas.0403198102