Anti-hepatoma effect of taccalonolide A through suppression of sonic hedgehog pathway

Autor: Hui Tian, Zhenkun He

Publikováno v: Artificial Cells, Nanomedicine, and Biotechnology, Vol 48, Iss 1, Pp 939-947 (2020)

Taccalonolide A has been reported to have anti-tumour efficiency. However, the underlying mechanism for taccalonolides A therapy of hepatocellular carcinoma (HCC) is still obscure. Cell viability was evaluated by cell counting kit-8 (CCK-8) assay. Ap

Externí odkaz: https://doaj.org/article/4137575516e641d19ecaaa3aa937579d

Development of Taccalonolide AJ-Hydroxypropyl-β-Cyclodextrin Inclusion Complexes for Treatment of Clear Cell Renal-Cell Carcinoma

Autor: Jing Han, Siwang Zhang, Junxin Niu, Chunli Zhang, Weichen Dai, Yuanyuan Wu, Lihong Hu

Publikováno v: Molecules, Vol 25, Iss 23, p 5586 (2020)

Background: Microtubule-targeted drugs are the most effective drugs for adult patients with certain solid tumors. Taccalonolide AJ (AJ) can stabilize tubulin polymerization by covalently binding to β-tubulin, which enables it to play a role in the t

Externí odkaz: https://doaj.org/article/f51d0880623c41caa5bf24d982a77475

Taccalonolides: A Novel Class of Microtubule-Stabilizing Anticancer Agents

Autor: Jiangnan Peng, Angela Winstead, Hongtao Yu, Xiaoyan Chen

Publikováno v: Cancers, Vol 13, Iss 920, p 920 (2021)
Cancers

Simple Summary Natural products have continued to play an important role in new drug discovery with a considerable number of marketed drugs being derived from naturally occurring compounds, particularly in the area of cancer. Taccalonolides are a new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab402f9ebe52398738fb90503db4eb52
https://www.mdpi.com/2072-6694/13/4/920

Drugs That Changed Society: Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides

Autor: Søren Brøgger Christensen

Publikováno v: Christensen, S B 2022, ' Drugs That Changed Society : Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides ', Molecules, vol. 27, no. 17, 5648 . https://doi.org/10.3390/molecules27175648

During a screening performed by the National Cancer Institute in the 1960s, the terpenoidpaclitaxel was discovered. Paclitaxel expanded the treatment options for breast, lung, prostateand ovarian cancer. Paclitaxel is only present in minute amounts i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b01c7d3267e0d596eb5fc36aa03bde
https://doi.org/10.3390/molecules27175648

Taccalonolide C-6 Analogues, Including Paclitaxel Hybrids, Demonstrate Improved Microtubule Polymerizing Activities

Autor: April L. Risinger, Shayne D. Hastings, Lin Du

Publikováno v: J Nat Prod

The C-22,23-epoxy taccalonolides are microtubule stabilizers that bind covalently to β-tubulin with a high degree of specificity. We semisynthesized and performed biochemical and cellular evaluations on 20 taccalonolide analogues designed to improve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f43008ffe0e746c29cfc00adf71b7b
https://europepmc.org/articles/PMC8656239/