Hemochromatosis risk genotype is not associated with colorectal cancer or age at its diagnosis

Autor: Gail P. Jarvik, Xiaoliang Wang, Pierre Fontanillas, Esther Kim, Sirisak Chanprasert, Adam S. Gordon, Lisa Bastarache, Kris V. Kowdley, Tabitha Harrison, Elisabeth A. Rosenthal, Ian B. Stanaway, Stéphane Bézieau, Stephanie J. Weinstein, Polly A. Newcomb, Graham Casey, Elizabeth A. Platz, Kala Visvanathan, Loic Le Marchand, Cornelia M. Ulrich, Sheetal Hardikar, Christopher I. Li, Franzel J.B. van Duijnhoven, Andrea Gsur, Peter T. Campbell, Victor Moreno, Pavel Vodička, Hermann Brenner, Jenny Chang-Claude, Michael Hoffmeister, Martha L. Slattery, Marc J. Gunter, Elom K. Aglago, Sergi Castellví-Bel, Sun-Seog Kweon, Andrew T. Chan, Li Li, Wei Zheng, D. Timothy Bishop, Graham G. Giles, Gad Rennert, Kenneth Offit, Temitope O. Keku, Michael O. Woods, Jochen Hampe, Bethan Van Guelpen, Steven J. Gallinger, Albert de la Chapelle, Heather Hampel, Sonja I. Berndt, Catherine M. Tangen, Annika Lindblom, Alicja Wolk, Andrea Burnett-Hartman, Anna H. Wu, Emily White, Stephen B. Gruber, Mark A. Jenkins, Joanna Mountain, Ulrike Peters, David R. Crosslin

Publikováno v: HGG Advances, Vol 1, Iss 1, Pp 100010- (2020)

Summary: Homozygotes for the higher penetrance hemochromatosis risk allele, HFE c.845G>A (p.Cys282Tyr, or C282Y), have been reported to be at a 2- to 3-fold increased risk for colorectal cancer (CRC). These results have been reported for small sample

Externí odkaz: https://doaj.org/article/c85b050649fe427483d2111e07f0a855

Genome-Wide Association Study of Serum Selenium Concentrations

Autor: Ulrike Peters, James R. Marshall, Charles B. Eaton, Stephen J. Chanock, Yan Liu, Carolyn Hutter, David Duggan, Xiaoling Song, Tabitha Harrison, Irena B. King, Stefan Stürup, Jian Gong, Li Hsu

Publikováno v: Nutrients, Vol 5, Iss 5, Pp 1706-1718 (2013)

Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however,

Externí odkaz: https://doaj.org/article/9969f0055c3e40d099938598116fbf5d

The association between genetically elevated polyunsaturated fatty acids and risk of cancer

Autor: Philip C. Haycock, Maria Carolina Borges, Kimberley Burrows, Rozenn N. Lemaitre, Stephen Burgess, Nikhil K. Khankari, Konstantinos K. Tsilidis, Tom R. Gaunt, Gibran Hemani, Jie Zheng, Therese Truong, Brenda M. Birmann, Tracy OMara, Amanda B. Spurdle, Mark M. Iles, Matthew H. Law, Susan L. Slager, Fatemeh Saberi Hosnijeh, Daniela Mariosa, Michelle Cotterchio, James R. Cerhan, Ulrike Peters, Stefan Enroth, Puya Gharahkhani, Loic Le Marchand, Ann C. Williams, Robert C. Block, Christopher I. Amos, Rayjean J. Hung, Wei Zheng, Marc J. Gunter, George Davey Smith, Caroline Relton, Richard M. Martin, Nathan Tintle, Terri Rice, Iona Cheng, Mark Jenkins, Steve Gallinger, Alex J. Cornish, Amit Sud, Jayaram Vijayakrishnan, Margaret Wrensch, Mattias Johansson, Aaron D. Norman, Alison Klein, Alyssa Clay-Gilmour, Andre Franke, Andres V. Ardisson Korat, Bill Wheeler, Björn Nilsson, Caren Smith, Chew-Kiat Heng, Ci Song, David Riadi, Elizabeth B. Claus, Eva Ellinghaus, Evgenia Ostroumova, null Hosnijeh, Florent de Vathaire, Giovanni Cugliari, Giuseppe Matullo, Irene Oi-Lin Ng, Jeanette E. Passow, Jia Nee Foo, Jiali Han, Jianjun Liu, Jill Barnholtz-Sloan, Joellen M. Schildkraut, John Maris, Joseph L. Wiemels, Kari Hemminki, Keming Yang, Lambertus A. Kiemeney, Lang Wu, Laufey Amundadottir, Marc-Henri Stern, Marie-Christine Boutron, Mark Martin Iles, Mark P. Purdue, Martin Stanulla, Melissa Bondy, Mia Gaudet, Lenha Mobuchon, Nicola J. Camp, Pak Chung Sham, Pascal Guénel, Paul Brennan, Philip R. Taylor, Quinn Ostrom, Rachael Stolzenberg-Solomon, Rajkumar Dorajoo, Richard Houlston, Robert B. Jenkins, Sharon Diskin, Sonja I. Berndt, Spiridon Tsavachidis, Stephen J. Channock, Tabitha Harrison, Tessel Galesloot, Ulf Gyllensten, Vijai Joseph, Y. Shi, Wenjian Yang, Yi Lin, Stephen K. Van Den Eeden

Publikováno v: Haycock, P C, Borges, M C, Burrows, K, Gaunt, T R, Hemani, G, Williams, A C, Davey Smith, G, Relton, C L & Martin, R M 2023, ' The association between genetically elevated polyunsaturated fatty acids and risk of cancer ', EBioMedicine, vol. 91, 104510 . https://doi.org/10.1016/j.ebiom.2023.104510

BackgroundThe causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain.MethodsUsing a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in European

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e902eeee7d75ecf1a6cf94541789012e
https://research-information.bris.ac.uk/en/publications/7cd08dd1-622d-4072-b9f5-dc6bdf4f3c0f

Data from A Pooled Analysis of Smoking and Colorectal Cancer: Timing of Exposure and Interactions with Environmental Factors

Autor: Ulrike Peters, John Potter, Emily White, Greg Warnick, Fridtjof Thomas, Deanna Stelling, Martha L. Slattery, Daniela Seminara, Robert Schoen, Thomas Rohan, Amanda I. Phipps, Bethann Pflugeisen, Polly Newcomb, Noralane M. Lindor, Yi Lin, Shuo Jiao, Li Hsu, Richard Hayes, Tabitha Harrison, Edward Giovannucci, Steven Gallinger, Charles S. Fuchs, Michelle Cotterchio, Andrew T. Chan, Graham Casey, Peter T. Campbell, Bette Caan, Sonja Berndt, John A. Baron, Carolyn Hutter, Jian Gong

Background: Considerable evidence suggests that cigarette smoking is associated with a higher risk of colorectal cancer (CRC). What is unclear, however, is the impact of quitting smoking on risk attenuation and whether other risk factors for CRC modi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36361b8044b0a9288cefe512dfacd7cb
https://doi.org/10.1158/1055-9965.c.6516213.v1

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Autor: Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Schmit, Virginia Díez-Obrero, Li Hsu, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Briggs, Victoria Svinti, Kevin Donnelly, Susan Farrington, James Blackmur, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Broderick, James Studd, Jeroen Huyghe, Tabitha Harrison, David Conti, Christopher Dampier, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obón-Santacana, Vicente Martín-Sánchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Hopper, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Duggan, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Böhm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hänninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Männistö, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellví-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Hunter, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Chanock, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stéphane Bézieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters

Publikováno v: Nature Genetics 55 (2023) 1
Nat Genet
Nature Genetics, 55(1), 89-99
Fernandez-rozadilla, C, Timofeeva, M, Chen, Z, Law, P, Thomas, M, Schmit, S, Díez-obrero, V, Hsu, L, Fernandez-tajes, J, Palles, C, Sherwood, K, Briggs, S, Svinti, V, Donnelly, K, Farrington, S, Blackmur, J, Vaughan-shaw, P, Shu, X, Long, J, Cai, Q, Guo, X, Lu, Y, Broderick, P, Studd, J, Huyghe, J, Harrison, T, Conti, D, Dampier, C, Devall, M, Schumacher, F, Melas, M, Rennert, G, Obón-santacana, M, Martín-sánchez, V, Moratalla-navarro, F, Oh, J H, Kim, J, Jee, S H, Jung, K J, Kweon, S, Shin, M, Shin, A, Ahn, Y, Kim, D, Oze, I, Wen, W, Matsuo, K, Matsuda, K, Tanikawa, C, Ren, Z, Gao, Y, Jia, W, Hopper, J, Jenkins, M, Win, A K, Pai, R, Figueiredo, J, Haile, R, Gallinger, S, Woods, M, Newcomb, P, Duggan, D, Cheadle, J, Kaplan, R, Maughan, T, Kerr, R, Kerr, D, Kirac, I, Böhm, J, Mecklin, L, Jousilahti, P, Knekt, P, Aaltonen, L, Rissanen, H, Pukkala, E, Eriksson, J, Cajuso, T, Hänninen, U, Kondelin, J, Palin, K, Tanskanen, T, Renkonen-sinisalo, L, Zanke, B, Männistö, S, Albanes, D, Weinstein, S, Ruiz-narvaez, E, Palmer, J, Buchanan, D, Platz, E, Visvanathan, K, Ulrich, C, Siegel, E, Brezina, S, Gsur, A, Campbell, P, Chang-claude, J, Hoffmeister, M, Brenner, H, Slattery, M, Potter, J, Tsilidis, K, Schulze, M, Gunter, M, Murphy, N, Castells, A, Castellví-bel, S, Moreira, L, Arndt, V, Shcherbina, A, Stern, M, Pardamean, B, Bishop, T, Giles, G, Southey, M, Idos, G, Mcdonnell, K, Abu-ful, Z, Greenson, J, Shulman, K, Lejbkowicz, F, Offit, K, Su, Y, Steinfelder, R, Keku, T, Van Guelpen, B, Hudson, T, Hampel, H, Pearlman, R, Berndt, S, Hayes, R, Martinez, M E, Thomas, S, Corley, D, Pharoah, P, Larsson, S, Yen, Y, Lenz, H, White, E, Li, L, Doheny, K, Pugh, E, Shelford, T, Chan, A, Cruz-correa, M, Lindblom, A, Hunter, D, Joshi, A, Schafmayer, C, Scacheri, P, Kundaje, A, Nickerson, D, Schoen, R, Hampe, J, Stadler, Z, Vodicka, P, Vodickova, L, Vymetalkova, V, Papadopoulos, N, Edlund, C, Gauderman, W, Thomas, D, Shibata, D, Toland, A, Markowitz, S, Kim, A, Chanock, S, Van Duijnhoven, F, Feskens, E, Sakoda, L, Gago-dominguez, M, Wolk, A, Naccarati, A, Pardini, B, Fitzgerald, L, Lee, S C, Ogino, S, Bien, S, Kooperberg, C, Li, C, Lin, Y, Prentice, R, Qu, C, Bézieau, S, Tangen, C, Mardis, E, Yamaji, T, Sawada, N, Iwasaki, M, Haiman, C, Le Marchand, L, Wu, A, Qu, C, Mcneil, C, Coetzee, G, Hayward, C, Deary, I, Harris, S, Theodoratou, E, Reid, S, Walker, M, Ooi, L Y, Moreno, V, Casey, G, Gruber, S, Tomlinson, I, Zheng, W, Dunlop, M, Houlston, R & Peters, U 2022, ' Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries ', Nature Genetics . https://doi.org/10.1038/s41588-022-01222-9, https://doi.org/10.1038/s41588-022-01222-9

Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and East Asian ancestry, identifying 205 independent risk associations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15df4717f873c1a13103310e40445c44
https://research.wur.nl/en/publications/deciphering-colorectal-cancer-genetics-through-multi-omic-analysi