Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression.

Autor: Degnan AP; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Tora GO; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Huang H; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Conlon DA; Chemical Development, Bristol-Myers Squibb Company , New Brunswick, New Jersey 08903, United States., Davis CD; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Hanumegowda UM; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Hou X; Department of Chemical Synthesis, Bristol-Myers Squibb Company , Princeton, New Jersey 08543, United States., Hsiao Y; Chemical Development, Bristol-Myers Squibb Company , New Brunswick, New Jersey 08903, United States., Hu J; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Krause R; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Li YW; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Newton AE; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Pieschl RL; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Raybon J; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Rosner T; Chemical Development, Bristol-Myers Squibb Company , New Brunswick, New Jersey 08903, United States., Sun JH; Department of Chemical Synthesis, Bristol-Myers Squibb Company , Princeton, New Jersey 08543, United States., Taber MT; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Taylor SJ; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Wong MK; Department of Chemical Synthesis, Bristol-Myers Squibb Company , Princeton, New Jersey 08543, United States., Zhang H; Department of Chemical Synthesis, Bristol-Myers Squibb Company , Princeton, New Jersey 08543, United States., Lodge NJ; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Bronson JJ; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Macor JE; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States., Gillman KW; Research and Development, Bristol-Myers Squibb Company , Wallingford, Connecticut 06492, United States.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2016 Dec 21; Vol. 7 (12), pp. 1635-1640. Date of Electronic Publication: 2016 Oct 18.

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