The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Autor: El Bairi, K., Haynes, H. R., Blackley, E., Fineberg, S., Shear, J., Turner, S., de Freitas, J. R., Sur, D., Amendola, L. C., Gharib, M., Kallala, A., Arun, I., Azmoudeh-Ardalan, F., Fujimoto, L., Sua, L. F., Liu, S. -W., Lien, H. -C., Kirtani, P., Balancin, M., El Attar, H., Guleria, P., Yang, W., Shash, E., Chen, I. -C., Bautista, V., Do Prado Moura, J. F., Rapoport, B. L., Castaneda, C., Spengler, E., Acosta-Haab, G., Frahm, I., Sanchez, J., Castillo, M., Bouchmaa, N., Md Zin, R. R., Shui, R., Onyuma, T., Husain, Z., Willard-Gallo, K., Coosemans, A., Perez, E. A., Provenzano, E., Ericsson, P. G., Richardet, E., Mehrotra, R., Sarancone, S., Ehinger, A., Rimm, D. L., Bartlett, J. M. S., Viale, G., Denkert, C., Hida, A. I., Sotiriou, C., Loibl, S., Hewitt, S. M., Badve, S., Symmans, W. F., Kim, R. S., Pruneri, G., Goel, S., Francis, P. A., Inurrigarro, G., Yamaguchi, R., Garcia-Rivello, H., Horlings, H., Afqir, S., Salgado, R., Adams, S., Kok, M., Dieci, M. 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S., El Gabry, E., Saltz, J., Bria, E., Garufi, G., Hartman, J., Sebastian, M., Olofsson, H., Kooreman, L., Cucherousset, J., Mathieu, M. -C., Ballesteros-Merino, C., Siziopikou, P., Fong, J., Klein, M., Qulis, I. R. I., Wesseling, J., Bellolio, E., Araya, J. C., Naber, S., Cheang, M., Castellano, I., Ales, A., Laenkholm, A. -V., Kulka, J., Quinn, C., Sapino, A., Amendoeira, I., Marchio, C., Braybrooke, J., Vincent-Salomon, A., Korski, K. P., Sofopoulos, M., Stovgaard, E. I. S., Bianchi, S., Bago-Horvath, Z., Yu, C., Regitnig, P., Hall, S., Kos, Z., Sant, S., Tille, J. -C., Gallas, B., Bethmann, D., Savas, P., Mendes, L., Soler, T., van Seijen, M., Gruosso, T., Quintana, A., Giltnane, J., Van den Eynden, G., Duregon, E., de Cabo, R., Recamo, P. C., Gaboury, L., Zimmerman, J., Pop, C. S., Wernicke, A., Williams, D., Gill, A., Solomon, B., Thapa, B., Farshid, G., Gilham, L., Christie, M., O'Toole, S., Hendry, S., Fox, S. B., Luen, S. J., Lakhani, S. 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H., Leung, S., Nielsen, T., Shi, L., Balslev, E., Thagaard, J., Almangush, A., Makitie, A., Joensuu, H., Lundin, J., Drubay, D., Roblin, E., Andre, F., Penault-Llorca, F., Lemonnier, J., Adam, J., Lacroix-Triki, M., Ternes, N., Radosevic-Robin, N., Klaushen, F., Weber, K., Harbeck, N., Gluz, O., Wienert, S., Cserni, G., Vingiani, A., Criscitiello, C., Solinas, C., Curigliano, G., Konishi, E., Suzuki, E., Yoshikawa, K., Kawaguchi, K., Takada, M., Toi, M., Ishida, M., Shibata, N., Saji, S., Kogawa, T., Sakatani, T., Okamoto, T., Moriya, T., Kataoka, T., Shimoi, T., Sugie, T., Mukohara, T., Shu, Y., Kikawa, Y., Kozuka, Y., Sayed, S., Rahayu, R., Ramsaroop, R., Senkus-Konefka, E., Chmielik, E., Cardoso, F., Ribeiro, J., Chan, J., Dent, R., Martin, M., Hagen, C., Guerrero, A., Rojo, F., Comerma, L., Nuciforo, P., Serrano, V. V., Camaea, V. 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Publikováno v: NPJ breast cancer, Vol. 7, no.1, p. 150 [1-17] (2021)
NPJ BREAST CANCER
npj Breast Cancer
npj Breast Cancer, Nature, 2021, 7 (1), ⟨10.1038/s41523-021-00346-1⟩
NPJ Breast Cancer
El Bairi, K, Haynes, H R, Blackley, E, Fineberg, S, Shear, J, Turner, S, de Freitas, J R, Sur, D, Amendola, L C, Gharib, M, Kallala, A, Arun, I, Azmoudeh-Ardalan, F, Fujimoto, L, Sua, L F, Liu, S W, Lien, H C, Kirtani, P, Balancin, M, El Attar, H, Guleria, P, Yang, W, Shash, E, Chen, I C, Bautista, V, Do Prado Moura, J F, Rapoport, B L, Castaneda, C, Spengler, E, Acosta-Haab, G, Frahm, I, Sanchez, J, Castillo, M, Bouchmaa, N, Md Zin, R R, Shui, R, Onyuma, T, Yang, W, Husain, Z, Willard-Gallo, K, Coosemans, A, Perez, E A, Provenzano, E, Choi, H J, Laenkholm, A V, Stovgaard, E I S, Nielsen, T, Balslev, E, Sharma, A, Singh, R & The International Immuno-Oncology Biomarker Working Group 2021, ' The tale of TILs in breast cancer : A report from The International Immuno-Oncology Biomarker Working Group ', npj Breast Cancer, vol. 7, no. 1, 150 . https://doi.org/10.1038/s41523-021-00346-1
npj Breast Cancer, Vol 7, Iss 1, Pp 1-17 (2021)

The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b5e1f9525daaabf93e8da1ce683a07
https://www.repository.cam.ac.uk/handle/1810/331501

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Autor: Kos, Z., Roblin, E., Kim, R. S., Michiels, S., Gallas, B. D., Chen, W., van de Vijver, K. K., Goel, S., Adams, S., Demaria, S., Viale, G., Nielsen, T. O., Badve, S. S., Symmans, W. F., Sotiriou, C., Rimm, D. L., Hewitt, S., Denkert, C., Loibl, S., Luen, S. J., Bartlett, J. M. S., Savas, P., Pruneri, G., Dillon, D. A., Cheang, M. C. U., Tutt, A., Hall, J. A., Kok, M., Horlings, H. M., Madabhushi, A., van der Laak, J., Ciompi, F., Laenkholm, A. -V., Bellolio, E., Gruosso, T., Fox, S. B., Araya, J. C., Floris, G., Hudecek, J., Voorwerk, L., Beck, A. H., Kerner, J., Larsimont, D., Declercq, S., Van den Eynden, G., Pusztai, L., Ehinger, A., Yang, W., Abduljabbar, K., Yuan, Y., Singh, R., Hiley, C., Bakir, M., Lazar, A. J., Naber, S., Wienert, S., Castillo, M., Curigliano, G., Dieci, M. -V., Andre, F., Swanton, C., Reis-Filho, J., Sparano, J., Balslev, E., Chen, I. -C., Stovgaard, E. I. S., Pogue-Geile, K., Blenman, K. R. M., Penault-Llorca, F., Schnitt, S., Lakhani, S. R., Vincent-Salomon, A., Rojo, F., Braybrooke, J. P., Hanna, M. G., Soler-Monso, M. T., Bethmann, D., Castaneda, C. A., Willard-Gallo, K., Sharma, A., Lien, H. -C., Fineberg, S., Thagaard, J., Comerma, L., Gonzalez-Ericsson, P., Brogi, E., Loi, S., Saltz, J., Klaushen, F., Cooper, L., Amgad, M., Moore, D. A., Salgado, R., Hyytiainen, A., Hida, A. I., Thompson, A., Lefevre, A., Gown, A., Lo, A., Sapino, A., Moreira, A. M., Richardson, A., Vingiani, A., Bellizzi, A. M., Guerrero, A., Grigoriadis, A., Garrido-Castro, A. C., Cimino-Mathews, A., Srinivasan, A., Acs, B., Singh, B., Calhoun, B., Haibe-Kans, B., Solomon, B., Thapa, B., Nelson, B. H., Ballesteroes-Merino, C., Criscitiello, C., Boeckx, C., Colpaert, C., Quinn, C., Chennubhotla, C. S., Solinas, C., Drubay, D., Sabanathan, D., Peeters, D., Zardavas, D., Hoflmayer, D., Johnson, D. B., Thompson, E. A., Perez, E., Elgabry, E. A., Blackley, E. F., Reisenbichler, E., Chmielik, E., Gaire, F., F. -I., Lu, Azmoudeh-Ardalan, F., Peale, F., Hirsch, F. R., Acosta-Haab, G., Farshid, G., Broeckx, G., Koeppen, H., Haynes, H. R., Mcarthur, H., Joensuu, H., Olofsson, H., Cree, I., Nederlof, I., Frahm, I., Brcic, I., Chan, J., Ziai, J., Brock, J., Weseling, J., Giltnane, J., Lemonnier, J., Zha, J., Ribeiro, J., Lennerz, J. K., Carter, J. M., Hartman, J., Hainfellner, J., Le Quesne, J., Juco, J. W., van den Berg, J., Sanchez, J., Cucherousset, J., Adam, J., Balko, J. M., Saeger, K., Siziopikou, K., Sikorska, K., Weber, K., Steele, K. E., Emancipator, K., El Bairi, K., Allison, K. H., Korski, K., Buisseret, L., Shi, L., Kooreman, L. F. S., Molinero, L., Estrada, M. V., Van Seijen, M., Lacroix-Triki, M., Sebastian, M. M., Balancin, M. L., Mathieu, M. -C., van de Vijver, M., Rebelatto, M. C., Piccart, M., Goetz, M. P., Preusser, M., Khojasteh, M., Sanders, M. E., Regan, M. M., Barnes, M., Christie, M., Misialek, M., Ignatiadis, M., de Maaker, M., Van Bockstal, M., Harbeck, N., Tung, N., Laudus, N., Sirtaine, N., Burchardi, N., Ternes, N., Radosevic-Robin, N., Gluz, O., Grimm, O., Nuciforo, P., Jank, P., Kirtani, P., Watson, P. H., Jelinic, P., Francis, P. A., Russell, P. A., Pierce, R. H., Hills, R., Leon-Ferre, R., de Wind, R., Shui, R., Leung, S., Tabbarah, S., Souza, S. C., O'Toole, S., Swain, S., Dudgeon, S., Willis, S., Ely, S., Bedri, S., Irshad, S., Liu, S., Hendry, S., Bianchi, S., Braganca, S., Paik, S., Luz, S., Gevaert, T., D'Alfons, T., John, T., Sugie, T., Kurkure, U., Bossuyt, V., Manem, V., Camaea, V. P., Tong, W., Tran, W. T., Wang, Y., Allory, Y., Husain, Z., Bago-Horvath, Z.

Publikováno v: npj Breast Cancer
npj Breast Cancer, Nature, 2020, 6 (1), pp.17. ⟨10.1038/s41523-020-0156-0⟩
NPJ BREAST CANCER
NPJ breast cancer, 6, 1
Dipòsit Digital de la UB
Universidad de Barcelona
npj Breast Cancer, 6(1):17. Nature Publishing Group
The International Immuno-Oncology Biomarker Working Group 2020, ' Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer ', npj Breast Cancer, vol. 6, no. 1, 17 . https://doi.org/10.1038/s41523-020-0156-0
NPJ breast cancer, 6
Kos, Z, Roblin, E, Kim, R S, Michiels, S, Gallas, B D, Chen, W, van de Vijver, K K, Goel, S, Adams, S, Demaria, S, Viale, G, Nielsen, T O, Badve, S S, Symmans, W F, Sotiriou, C, Rimm, D L, Hewitt, S, Denkert, C, Loibl, S, Luen, S J, Bartlett, J M S, Savas, P, Pruneri, G, Dillon, D A, Cheang, M C U, Tutt, A, Hall, J A, Kok, M, Horlings, H M, Madabhushi, A, van der Laak, J, Ciompi, F, Laenkholm, A-V, Bellolio, E, Gruosso, T, Fox, S B, Araya, J C, Floris, G, Hudeček, J, Voorwerk, L, Beck, A H, Kerner, J, Larsimont, D, Declercq, S, Van den Eynden, G, Pusztai, L, Ehinger, A, Singh, R, Balslev, E, Stovgaard, E I S & International Immuno-Oncology Biomarker Working Group 2020, ' Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer ', npj Breast Cancer, vol. 6, pp. 17 . https://doi.org/10.1038/s41523-020-0156-0
NPJ Breast Cancer
npj Breast Cancer, Vol 6, Iss 1, Pp 1-16 (2020)
npj Breast Cancer, 2020, 6 (1), pp.17. ⟨10.1038/s41523-020-0156-0⟩
2020, ' Pitfalls in Assessing Stromal Tumor Infiltrating Lymphocytes (sTILs) in Breast Cancer ', NPJ Breast Cancer . https://doi.org/10.1038/s41523-020-0156-0

Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4063f2cd24ffe1264c2ae53c506385ac
https://lirias.kuleuven.be/handle/123456789/655365

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Autor: Hudecek, J., Voorwerk, L., van Seijen, M., Nederlof, I., de Maaker, M., van den Berg, J., van de Vijver, K. K., Sikorska, K., Adams, S., Demaria, S., Viale, G., Nielsen, T. O., Badve, S. S., Michiels, S., Symmans, W. F., Sotiriou, C., Rimm, D. L., Hewitt, S. M., Denkert, C., Loibl, S., Loi, S., Bartlett, J. M. S., Pruneri, G., Dillon, D. A., Cheang, M. C. U., Tutt, A., Hall, J. A., Kos, Z., Salgado, R., Kok, M., Horlings, H. M., Hyytiainen, A., Hida, A. I., Thompson, A., Lefevre, A., Lazar, A. J., Gown, A., Lo, A., Sapino, A., Madabhushi, A., Moreira, A., Richardson, A., Vingiani, A., Beck, A. H., Bellizzi, A. M., Guerrero, A., Grigoriadis, A., Ehinger, A., Garrido-Castro, A., Vincent-Salomon, A., Laenkholm, A. -V., Sharma, A., Cimino-Mathews, A., Srinivasan, A., Acs, B., Singh, B., Calhoun, B., Haibe-Kans, B., Solomon, B., Thapa, B., Nelson, B. H., Gallas, B. D., Castaneda, C., Ballesteros-Merino, C., Criscitiello, C., Boeckx, C., Colpaert, C., Quinn, C., Chennubhotla, C. S., Swanton, C., Solinas, C., Hiley, C., Drubay, D., Bethmann, D., Moore, D. A., Larsimont, D., Sabanathan, D., Peeters, D., Zardavas, D., Hoflmayer, D., Johnson, D. B., Thompson, E. A., Brogi, E., Perez, E., Elgabry, E. A., Stovgaard, E. S., Blackley, E. F., Roblin, E., Reisenbichler, E., Bellolio, E., Balslev, E., Chmielik, E., Gaire, F., Andre, F., F. -I., Lu, Azmoudeh-Ardalan, F., Rojo, F., Gruosso, T., Ciompi, F., Peale, F., Hirsch, F. R., Klauschen, F., Penault-Llorca, F., Acosta Haab, G., Farshid, G., van den Eynden, G., Curigliano, G., Floris, G., Broeckx, G., Gonzalez-Ericsson, Koeppen, H., Haynes, H. R., Mcarthur, H., Joensuu, H., Olofsson, H., Lien, H. -C., Chen, I. -C., Cree, I., Frahm, I., Brcic, I., Chan, J., Ziai, J., Brock, J., Wesseling, J., Giltnane, J., Kerner, J. K., Thagaard, J., Braybrooke, J. P., van der Laak, J. A. W. M., Lemonnier, J., Zha, J., Ribeiro, J., Lennerz, J. K., Carter, J. M., Saltz, J., Hartman, J., Hainfellner, J., Quesne, J. L., Juco, J. W., Reis-Filho, J., Sanchez, J., Sparano, J., Cucherousset, J., Araya, J. C., Adam, J., Balko, J. M., Saeger, K., Siziopikou, K., Willard-Gallo, K., Weber, K., Pogue-Geile, K. L., Steele, K. E., Emancipator, K., Abduljabbar, K., El Bairi, K., Blenman, K. R. M., Allison, K. H., Korski, K., Pusztai, L., Comerma, L., Buisseret, L., Cooper, L. A. D., Shi, L., Kooreman, L. F. S., Molinero, L., Estrada, M. V., Lacroix-Triki, M., Al Bakir, M., Sebastian, M. M., van de Vijver, M., Balancin, M. L., Dieci, M. V., Mathieu, M. -C., Rebelatto, M. C., Piccart, M., Hanna, M. G., Goetz, M. P., Preusser, M., Khojasteh, M., Sanders, M. E., Regan, M. M., Barnes, M., Christie, M., Misialek, M., Ignatiadis, M., van Bockstal, M., Castillo, M., Amgad, M., Harbeck, N., Tung, N., Laudus, N., Sirtaine, N., Burchardi, N., Ternes, N., Radosevic-Robin, N., Gluz, O., Grimm, O., Nuciforo, P., Jank, P., Gonzalez-Ericsson, P., Kirtani, P., Jelinic, P., Watson, P. H., Savas, P., Francis, P. A., Russell, P. A., Singh, R., Kim, R. S., Pierce, R. H., Hills, R., Leon-Ferre, R., de Wind, R., Shui, R., De Clercq, S., Leung, S., Tabbarah, S., Souza, S. C., O'Toole, S., Swain, S., Dudgeon, S., Willis, S., Ely, S., Kim, S. -R., Bedri, S., Irshad, S., Liu, S. -W., Goel, S., Hendry, S., Bianchi, S., Braganca, S., Paik, S., Wienert, S., Fox, S. B., Luen, S. J., Naber, S., Schnitt, S. J., Sua, L. F., Lakhani, S. R., Fineberg, S., Soler, T., Gevaert, T., D'Alfonso, T., John, T., Sugie, T., Kurkure, U., Bossuyt, V., Manem, V., Camara, V. P., Tong, W., Chen, W., Yang, W., Tran, W. T., Wang, Y., Yuan, Y., Allory, Y., Husain, Z., Bago-Horvath, Z.

Publikováno v: NPJ breast cancer, 6
npj Breast Cancer
npj Breast Cancer, Nature, 2020, 6 (1), pp.15. ⟨10.1038/s41523-020-0155-1⟩
NPJ Breast Cancer
npj Breast Cancer, Vol 6, Iss 1, Pp 1-8 (2020)
2020, ' Application of a risk-management framework for integration of stromal Tumor Infiltrating Lymphocytes in clinical trials ', NPJ Breast Cancer . https://doi.org/10.1038/s41523-020-0155-1
NPJ BREAST CANCER
npj Breast Cancer, 2020, 6 (1), pp.15. ⟨10.1038/s41523-020-0155-1⟩

Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc0eed7935fac67e7046bd597e941f6
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/317463

Metabolomics-Based Machine Learning Models Accurately Predict Breast Cancer Estrogen Receptor Status.

Autor: Arumalla, Kamala K.¹ (AUTHOR) karumalla@alumni.harrisburgu.edu, Haince, Jean-François² (AUTHOR) jhaince@biomarkdiagnostics.com, Bux, Rashid A.³ (AUTHOR) rahmed@biomarkdiagnostics.com, Huang, Guoyu^2,3 (AUTHOR) ghuang@biomarkdiagnostics.com, Tappia, Paramjit S.⁴ (AUTHOR) ptappia@sbrc.ca, Ramjiawan, Bram^4,5 (AUTHOR) bramjiawan@sbrc.ca, Ford, W. Randolph¹ (AUTHOR) marriotts2010@gmail.com, Vaida, Maria¹ (AUTHOR) mvaida@harrisburgu.edu

Publikováno v: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 23, p13029. 14p.

Analysis of tumor nuclear features using artificial intelligence to predict response to neoadjuvant chemotherapy in high-risk breast cancer patients.

Autor: Dodington DW; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Lagree A; Biological Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada., Tabbarah S; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Mohebpour M; Biological Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada., Sadeghi-Naini A; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Electrical Engineering and Computer Science, York University, Toronto, ON, Canada., Tran WT; Biological Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada.; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.; Temerty Centre for Artificial Intelligence Research and Education in Medicine, University of Toronto, Toronto, ON, Canada., Lu FI; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. fangi.lu@sunnybrook.ca.; Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Rm E423a, Toronto, ON, M4N 3M5, Canada. fangi.lu@sunnybrook.ca.

Publikováno v: Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Apr; Vol. 186 (2), pp. 379-389. Date of Electronic Publication: 2021 Jan 23.