Výsledky vyhledávání - "Tabasum Sidiq"

Akademický článek

Nod2: a critical regulator of ileal microbiota and Crohn’s disease

Autor: Tabasum Sidiq, Sayuri Yoshihama, Isaac Downs, Koichi S Kobayashi

Publikováno v: Frontiers in Immunology, Vol 7 (2016)

The human intestinal tract harbors large bacterial community consisting of commensal, symbiotic and pathogenic strains, which are constantly interacting with the intestinal immune system. This interaction elicits a non-pathological basal level of imm

Externí odkaz: https://doaj.org/article/a45823758bf746d0b3da21f35ca45a73

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Class I transactivator, NLRC5: a central player in the MHC class I pathway and cancer immune surveillance

Autor: Saptha Vijayan, Tabasum Sidiq, Peter J. van den Elsen, Koichi Kobayashi, Suhail Yousuf

Publikováno v: Vijayan, S, Sidiq, T, Yousuf, S, van den Elsen, P J & Kobayashi, K S 2019, ' Class I transactivator, NLRC5: a central player in the MHC class I pathway and cancer immune surveillance ', Immunogenetics, vol. 71, no. 3, pp. 273-282 . https://doi.org/10.1007/s00251-019-01106-z

Major histocompatibility complex (MHC) class I and class II molecules play critical roles in the activation of the adaptive immune system by presenting antigens to CD8+ and CD4+ T cells, respectively. Although it has been well known that CIITA (MHC c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205855ff2ca28952506eaf2c8cb0c624
https://doi.org/10.1007/s00251-019-01106-z

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NLRC5/CITA: A Key Player in Cancer Immune Surveillance

Autor: Saptha Vijayan, Sayuri Yoshihama, Koichi Kobayashi, Tabasum Sidiq

Publikováno v: Trends in Cancer. 3:28-38

Cancer cells need to escape immune surveillance for successful tumor growth. Loss of MHC class I has been described as a major immune evasion strategy in many cancers. MHC class I transactivator (CITA), NLRC5 [nucleotide-binding domain and leucine-ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e58cc79ae9c6b633ddc5ec03dab5e2
https://doi.org/10.1016/j.trecan.2016.12.003

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Synthesis and immunopotentiating activity of novel isoxazoline functionalized coumarins

Autor: Halmuthur M. Sampath Kumar, Nasarul Islam, Abdul Rouf, Mohammad Sarwar Alam, Mahipal Yadav, Syed Shafi, Swarn Singh, Tabasum Sidiq, Parvinder Pal Singh, Tabasum Ismail, Varma Saikam, Kalicharan Sharma, Anamika Khajuria

Publikováno v: European Journal of Medicinal Chemistry. 123:90-104

A novel series (13) of isoxazoline functionalized coumarins was synthesized through 1,3-dipolar cyclization of nitrile oxides with Allylated coumarins. Synthesis of effective and target selective immunostimulators through conjugation of diversely sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39fcae89f78c4fce8bd7860ca7b5c6f
https://doi.org/10.1016/j.ejmech.2016.07.026

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NLRC5/MHC class I transactivator is a target for immune evasion in cancer

Autor: Isaac Downs, Bjoern Chapuy, Saptha Vijayan, Sayuri Yoshihama, Margaret A. Shipp, Gregory Lizée, Jason Roszik, Koichi Kobayashi, Tabasum Sidiq, Torsten B. Meissner

Publikováno v: Proceedings of the National Academy of Sciences. 113:5999-6004

Cancer cells develop under immune surveillance, thus necessitating immune escape for successful growth. Loss of MHC class I expression provides a key immune evasion strategy in many cancers, although the molecular mechanisms remain elusive. MHC class

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a34e7377bf56edfc51a8de7be524fa
https://doi.org/10.1073/pnas.1602069113

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CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression

Autor: Saptha Vijayan, Isaac Downs, Tabasum Sidiq, Koichi Kobayashi

Publikováno v: BioFactors. 42:349-357

Major histocompatibility complex (MHC) class I and class II molecules play essential roles in the development and activation of the human adaptive immune system. An NLR protein, CIITA (MHC class II transactivator) has been recognized as a master regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a6ed520be0d8e0e625c86922ffaabb4
https://doi.org/10.1002/biof.1285

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Design and Synthesis of Novel 1,2,3-Triazole- and 2-Isoxazoline-BasedBis-Heterocycles as Immune Potentiators

Autor: Anamika Khajuria, Irfan Hyder, Tabasum Sidiq, Sarvar M. Alam, Syed Shafi, Tabasum Ismail, M. Sampath Kumar Halmuthur

Publikováno v: Archiv der Pharmazie. 348:796-807

A series of novel bis-heterocycles encompassing isoxazolines and triazoles were synthesized through a novel one-pot procedure that involves in situ generation of nitrile oxide and its 1,3-dipolar cycloaddition to variedly substituted acrylates. The s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abad199c4e3a7f56889304b4b655fc43
https://doi.org/10.1002/ardp.201400398

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Role of NLRC5 and IRF1 in the induction of MHC class I

Autor: Saptha Vijayan, Torsten B. Meissner, Kyoung-Hee Lee, Yuen-Joyce Liu, Isaac Downs, Tabasum Sidiq, Chi Zhang, Peter J. van den Elsen, Koichi S. Kobayashi

Publikováno v: The Journal of Immunology. 202:64.20-64.20

MHC class I and MHC class II plays a major role in adaptive immune responses through activation of CD8+ T cells or CD4+ T cells respectively, by presenting intracellular or extracellular antigens. The MHC class I transactivator (CITA), NLRC5 was rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dc5af3d1aa473752bb5e0303357f763
https://doi.org/10.4049/jimmunol.202.supp.64.20

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