D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats

Autor: Antonello Bonci, Kelly Lei, F. Woodward Hopf, Jeffrey A. Simms, Taban Seif, Scott A. Wegner, Robert O. Messing

Publikováno v: Neuropsychopharmacology. 40:2357-2367

There is considerable interest in NMDAR modulators to enhance memory and treat neuropsychiatric disorders such as addiction, depression, and schizophrenia. D-serine and D-cycloserine, the NMDAR activators at the glycine site, are of particular intere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d2d43abb0f60faaf17eb899d73d3c1
https://doi.org/10.1038/npp.2015.84

The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing

Autor: Frederic Woodward Hopf, George Kunos, Taban Seif, Alexandros Makriyannis, Antonello Bonci

Publikováno v: Neuroscience. 193:21-33

Many motivated and addiction-related behaviors are sustained by activity of both dopamine D1- and D2-type receptors (D1Rs and D2Rs) as well as CB1 receptors (CB1Rs) in the nucleus accumbens (NAc). Here, we use in vitro whole-cell patch-clamp electrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b871008e23db076c2eaeecf6e3776435
https://doi.org/10.1016/j.neuroscience.2011.07.055

Endocytosis Promotes Rapid Dopaminergic Signaling

Autor: F. Woodward Hopf, Sarah J. Kotowski, Mark von Zastrow, Antonello Bonci, Taban Seif

Publikováno v: Neuron. 71(2):278-290

D(1) dopamine receptors are primary mediators of dopaminergic signaling in the CNS. These receptors internalize rapidly following agonist-induced activation, but the functional significance of this process is unknown. We investigated D(1) receptor en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd1011a6d024d09eb4509c965fb5e52

MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro

Autor: Shinjae Chung, Taban Seif, F. Woodward Hopf, Olivier Civelli

Publikováno v: PeerJ, Vol 1, p e61 (2013)
Hopf, FW; Seif, T; Chung, S; & Civelli, O. (2013). MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro. PeerJ, 2013(1). doi: 10.7717/peerj.61. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2kf910gb
PeerJ

The MCH and dopamine receptor systems have been shown to modulate a number of behaviors related to reward processing, addiction, and neuropsychiatric conditions such as schizophrenia and depression. In addition, MCH and dopamine receptors can interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11944ff7cd0ca57ce874a00e54ab475a
https://peerj.com/articles/61/

Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity

Autor: Antonello Bonci, Taban Seif, David Kapfhamer, Ulrike Heberlein, Viktor Kharazia, Karen H. Berger, F. Woodward Hopf

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(26)

There is considerable interest in the regulation of sensorimotor gating, since deficits in this process could play a critical role in the symptoms of schizophrenia and other psychiatric disorders. Sensorimotor gating is often studied in humans and ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d767712d63c210dfe5854116b35396
https://pubmed.ncbi.nlm.nih.gov/20592205