Monoclonal enolase-1 blocking antibody ameliorates pulmonary inflammation and fibrosis

Autor: Wei-Ching Huang, Chi-Fen Chuang, Yung-Tsang Huang, I-Che Chung, Mao-Lin Chen, Tung-Yueh Chuang, Xiu-Li Yang, Yu-Yau Chou, Chih-Hsin Liu, Nai-Yu Chen, Chun-Jen Chen, Ta-Tung Yuan

Publikováno v: Respiratory Research, Vol 24, Iss 1, Pp 1-15 (2023)

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic fatal disease with limited therapeutic options. The infiltration of monocytes and fibroblasts into the injured lungs is implicated in IPF. Enolase-1 (ENO1) is a cytosolic glycolytic

Externí odkaz: https://doaj.org/article/759c1be2a8654217be1fb3b6c082fdbc

Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6H-indolo[3,2-c]quinolin-6-ones as Potent Topoisomerase-I Inhibitors

Autor: Shu Fu Lin, Li-Wei Teng, Ya-Chi Huang, Shyh-Fong Chen, Guan-Ru Huang, Chih-Lin Chang, Pi-Chen Hsu, Min-Sian Huang, Yu-Sheng Gao, Ya-Wen Chan, Jiann-Jyh Huang, Sheng-Chuan Yang, Bo-Han Jian, Yann-Yu Lu, Yu-Fen Chen, Tzu-Hao Lo, Shih-Hsien Chuang, Wen-Yun Hsueh, Po-Hsun Huang, Hsin-Yi Huang, Lien-Hsiang Chang, Win-Yin Wei, Ying-Chou Chen, Her-Sheng Lin, Shan-Yen Chou, Ta-Tung Yuan, Yu-Ting Chao, Ying-Shuan E. Lee, Yi-Feng Kao, Yu-Hsiang Lin, Jo-Chu Lin, Hung-Huang Liu, Shao-Yun Wang, Chin-Hung Lai, Shin-Yi Huang

Publikováno v: Journal of Medicinal Chemistry. 64:1435-1453

In this paper, we present a copper(I)-catalyzed nitrile-addition/N-arylation ring-closure cascade for the synthesis of 5,11-dihydro-6H-indolo[3,2-c]quinolin-6-ones from 2-(2-bromophenyl)-N-(2-cyanophenyl)acetamides. Using CuBr and t-BuONa in dimethyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fcb962b8cc2da85f8b630161defbab0
https://doi.org/10.1021/acs.jmedchem.0c00727

A Novel Enolase-1 Antibody Targets Multiple Interacting Players in the Tumor Microenvironment of Advanced Prostate Cancer

Autor: Mao-Lin Chen, Ta-Tung Yuan, Chi-Fen Chuang, Yung-Tsang Huang, I-Che Chung, Wei-Ching Huang

Publikováno v: Molecular cancer therapeutics. 21(8)

Prostate cancer is one of the most common causes of cancer death in men worldwide, and the treatment options are limited for patients with advanced stages of prostate cancer. Upon oncogenic or inflammatory stimulation, tumor cells or immune cells exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d6a1052a4ddabaffc3b5cc8fe0aa95
https://pubmed.ncbi.nlm.nih.gov/35700013

The Anti-hepatitis B Virus Activity of Boehmeria nivea Extract in HBV-viremia SCID Mice

Autor: Le-Mei Hung, Yiu-Kay Lai, Kai-Ling Huang, Thomas Ta-Tung Yuan, Jia-Ming Chang

Publikováno v: Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-Based Complementary and Alternative Medicine, Vol 7, Iss 2, Pp 189-195 (2010)

Boehmeria niveaextract (BNE) is widely used in southern Taiwan as a folk medicine for hepato-protection and hepatitis treatment. In previous studies, we demonstrated that BNE could reduce the supernatant hepatitis B virus (HBV) DNA in HBV-producing H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d10b37460a8194112c0f41d75184a33
http://europepmc.org/articles/PMC2862930

Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species

Autor: Richard J. Lin, Neil G. Miyamoto, Pamela Toy, Peter J. Kretschmer, John McClary, Thomas Ta-Tung Yuan

Publikováno v: Gene. 278:41-51

We have cloned the full-length cDNA and genomic region of a human prostate specific G-protein coupled receptor with properties characteristic of an olfactory receptor. A partial cDNA sequence of this gene, called PSGR, was recently cloned. The gene c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480a97aabc3a0c8dfb660fcec174d312
https://doi.org/10.1016/s0378-1119(01)00709-0