Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Ta-Hsien Lin"'
Autor:
Yu-Ting Huang, An-Chieh Cheng, Hui-Chi Tang, Guo-Cheng Huang, Ling Cai, Ta-Hsien Lin, Kou-Juey Wu, Ping-Hui Tseng, Greg G. Wang, Wei-Yi Chen
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-11 (2021)
Abstract USP7, one of the most abundant ubiquitin-specific proteases (USP), plays multifaceted roles in many cellular events, including oncogenic pathways. Accumulated studies have suggested that USP7, through modulating the MDM2/MDMX-p53 pathway, is
Externí odkaz:
https://doaj.org/article/544bcba015934e9c8d44f0ccba4f1df9
Publikováno v:
Polymers, Vol 15, Iss 6, p 1444 (2023)
The properties of amyloid fibrils, e.g., unique structural characteristics and superior biocompatibility, make them a promising vehicle for drug delivery. Here, carboxymethyl cellulose (CMC) and whey protein isolate amyloid fibril (WPI-AF) were used
Externí odkaz:
https://doaj.org/article/16d3833f7f81400b822b7ea07cb08162
Autor:
Shu-Shun Hsueh, S.-S. (Steven) Wang, Shu-Han Chen, Chia-Lin Wang, W. (Josephine) Wu, Ta-Hsien Lin
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1591 (2022)
Human γD-crystallin (HGDC) is an abundant lens protein residing in the nucleus of the human lens. Aggregation of this and other structural proteins within the lens leads to the development of cataract. Much has been explored on the stability and agg
Externí odkaz:
https://doaj.org/article/8e4511b4df8c47a2a75a7f4e6a049adb
Autor:
Kai-Cyuan He, Yi-Ru Chen, Chu-Ting Liang, Shi-Jie Huang, Chung-Ying Tzeng, Chi-Fon Chang, Shing-Jong Huang, Hsien-Bin Huang, Ta-Hsien Lin
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2571 (2020)
Some mutations which occur in the α/β-discordant region (resides 15 to 23) of β-amyloid peptide (Aβ) lead to familial Alzheimer’s disease (FAD). In vitro studies have shown that these genetic mutations could accelerate Aβ aggregation. We recen
Externí odkaz:
https://doaj.org/article/170a070f8c3e4f7d9af821f05f808b05
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 1, Pp 1068-1079 (2014)
Phostensin is encoded by KIAA1949. 5'-RACEanalysis has been used to identify the translation start site of phostensin mRNA, indicating that it encodes 165 amino acids with an apparent molecular weight of 26 kDa on SDS-PAGE. This low-molecular-weight
Externí odkaz:
https://doaj.org/article/17ec715261b0488b8cc09bba0fe31827
Autor:
Chu-Ting Liang, Hsien-Bin Huang, Chih-Ching Wang, Yi-Ru Chen, Chi-Fon Chang, Ming-Shi Shiao, Yi-Cheng Chen, Ta-Hsien Lin
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154327 (2016)
β-amyloid peptide (Aβ) aggregation has been thought to be associated with the pathogenesis of Alzheimer's disease. Recently, we showed that L17A/F19A substitutions may increase the structural stability of wild-type and Arctic-type Aβ40 and decreas
Externí odkaz:
https://doaj.org/article/b7c44c3f74f54977bae6babf14526c7f
Autor:
Ta-Hsien Lin, Su-Qin Liu, Yu-Shan Lin, Chun-Yu Chen, Ming-Chi Lu, Hsien-Lu Huang, Kuang-Yung Huang, Ning-Sheng Lai, Tzu-Fan Wang, Hsien-Bin Huang
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 12, Pp 15967-15982 (2012)
Phostensin, a protein phosphatase 1 F-actin cytoskeleton-targeting subunit encoded by KIAA1949, consists of 165 amino acids and caps the pointed ends of actin filaments. Sequence alignment analyses suggest that the C-terminal region of phostensin, sp
Externí odkaz:
https://doaj.org/article/88083920d2d04b0da5ddb534cc54ae2d
Autor:
Yi-Ru Chen, Hsien-bin Huang, Chi-Jen Lo, Chih-Ching Wang, Li-Kang Ho, Hsin-Tzu Liu, Ming-Shi Shiao, Ta-Hsien Lin, Yi-Cheng Chen
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61874 (2013)
Alzheimer's disease is the most common form of neurodegenerative disease. Beta-amyloid peptides (Aβ) are responsible for neuronal death both in vitro and in vivo. Previously, L17 and F19 residues were identified as playing key roles in the stabiliza
Externí odkaz:
https://doaj.org/article/cff4d2865d334bd2b6ee9ebfbfe03c3e
Autor:
Chia-Anne Yang, Yung-Han Chen, Shyue-Chu Ke, Yi-Ru Chen, Hsien-Bin Huang, Ta-Hsien Lin, Yi-Cheng Chen
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
The neurotoxicity of Aβ is associated with the formation of free radical by interacting with redox active metals such as Cu2+. However, the relationship between ion-interaction, ion-driven free radical formation, and Aβ conformation remains to be f
Externí odkaz:
https://doaj.org/article/de8d321d66624aeb9a642011885ab9bf
Autor:
Cheng-Yuan Hsia, Anna F.Y. Li, Liang-Tsai Hsiao, Wing-Yiu Lui, Tai-Jay Chang, Kuang-Tzu Huang, Gar-Yang Chau, Chia-Lin Wang, Pin-Hsing Tsaia, Yueh Chien, Kung-Liang King, Ta-Hsien Lin
Publikováno v:
Journal of the Chinese Medical Association. 84:1100-1108
Background Hepatocellular carcinoma (HCC) ranks many tasks in clinical oncology due to possibly develop general tumor in men and, usually lead to malignant to death within years. Researches had reported about major factors for being HCC was male sex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b730b519fe535b6032ae3265ac5c61
https://doi.org/10.1097/jcma.0000000000000628
https://doi.org/10.1097/jcma.0000000000000628