Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ta-Hsiang Chao"'
Autor:
Tony E. Hugli, Yoshihiro Fukuoka, Jianzhong Sun, Richard D. Ye, Ta Hsiang Chao, Julia A. Ember
Publikováno v:
Protein Science. 8:2304-2311
The human C3a anaphylatoxin receptor (C3aR) is a G protein-coupled receptor (GPCR) composed of seven transmembrane alpha-helices connected by hydrophilic loops. Previous studies of chimeric C3aR/C5aR and loop deletions in C3aR demonstrated that the l
Autor:
Ta-Hsiang Chao, Saskia T. C. Neuteboom, Bharat B. Aggarwal, Anas Younes, Gautam Sethi, Madan M. Chaturvedi, Michael A. Palladino, Kwang Seok Ahn
Publikováno v:
Blood. 110:2286-2295
Salinosporamide A (also called NPI-0052), recently identified from the marine bacterium Salinispora tropica, is a potent inhibitor of 20S proteasome and exhibits therapeutic potential against a wide variety of tumors through a poorly understood mecha
Autor:
Lisardo Boscá, Saskia T. C. Neuteboom, Ta-Hsiang Chao, Michael A. Palladino, Emmanuel A. Theodorakis, Paqui G. Través, Antonio Castrillo, Sonsoles Hortelano, Thanh Lam, Miriam Zeini
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Terpenoids constitute a large family of natural steroids that are widely distributed in plants and insects. We investigated the effects of a series of diterpenes structurally related to acanthoic acid in macrophage functions. We found that diterpenes
Autor:
Saskia T. C. Neuteboom, Scott S Mitchell, Barbara C. M. Potts, Jianlin Xu, Gordafaried Deyanat-Yazdi, Sy Teisan, Ta-Hsiang Chao, Katherine Anne Reed, Rama Rao Manam, Kin S. Lam
Publikováno v:
Journal of Natural Products. 70:269-276
Salinosporamide A (NPI-0052; 3), a highly potent inhibitor of the 20S proteasome, is currently in phase I clinical trials for the treatment of cancer. During the course of purifying multigram quantities of 3 from Salinispora tropica fermentation extr
Autor:
Ta-Hsiang Chao, Lijun Xia, Saskia T. C. Neuteboom, Vito J. Palombella, James C. Cusack, Wei Niu, Michael A. Palladino, Rong Liu, Christine S. Pien
Publikováno v:
Clinical Cancer Research. 12:6758-6764
Purpose: In the current study, we examine the effects of a novel proteasome inhibitor, NPI-0052 (salinosporamide A), on proteasome function and nuclear factor-κB activation and evaluate its ability to enhance treatment response in colon cancer xenog
Autor:
Mugdha Velankar, Anthony Letai, Teru Hideshima, N. Mitsiades, Constantine S. Mitsiades, Dharminder Chauhan, Ta-Hsiang Chao, Huib Ovaa, Klaus Podar, Paul G. Richardson, Michael A. Palladino, Saskia T. C. Neuteboom, Kenneth C. Anderson, Benjamin Nicholson, Hiroshi Yasui, Celia R. Berkers, Guilan Li, Laurence Catley
Publikováno v:
Cancer Cell. 8(5):407-419
SummaryBortezomib therapy has proven successful for the treatment of relapsed and/or refractory multiple myeloma (MM); however, prolonged treatment is associated with toxicity and development of drug resistance. Here, we show that the novel proteasom
Autor:
Gordafaried Deyanat-Yazdi, Ta-Hsiang Chao, Paul R. Jensen, Bao Mai, Kin S. Lam, Barbara C. M. Potts, Michael A. Palladino, William Fenical, Saskia T. C. Neuteboom, Katherine Anne Reed, Benjamin Nicholson, Scott S Mitchell, Rama Rao Manam, Venkat R. Macherla
Publikováno v:
Journal of Medicinal Chemistry. 48:3684-3687
Salinosporamide A (1, NPI-0052) is a potent proteasome inhibitor in development for treating cancer. In this study, a series of analogues was assayed for cytotoxicity, proteasome inhibition, and inhibition of NF-kappaB activation. Marked reductions i
Autor:
Paqui G. Través, G. Kenneth Lloyd, Lyle L. Moldawer, Michael A. Palladino, Sonsoles Hortelano, Binh G. Vong, Lisardo Boscá, Emmanuel A. Theodorakis, Chinmay Chowdhury, Ta Hsiang Chao, Thanh Lam, F. Rena Bahjat
Publikováno v:
ChemBioChem. 6:133-144
The synthesis and the biological evaluation of a new family diterpenes are presented. The synthetic studies were inspired by the structural framework of acanthoic acid (1) and yielded a family of compounds that were evaluated as anti-inflammatory age
Autor:
Masaaki Hayashi, Young Yang, Ta Hsiang Chao, Charles C. King, Jiing Dwan Lee, Jeng Fan Lo, Richard I. Tapping
Publikováno v:
Journal of Biological Chemistry. 276:8631-8634
Activation of the mammalian mitogen-activated protein kinase known as BMK1 is required for growth factor-induced cell proliferation. To understand the mechanism by which BMK1 mediates this cellular response, this kinase was used as bait in a yeast tw
Publikováno v:
Immunologic Research. 21:233-238
Big mitogen-activated protein kinase (MAPK) 1 (BMK1), also known as ERK5, is a recently identified member of the mammalian MAPK family. Cellular stimulation of BMK1 is induced in response to growth factors, oxidative stress, and hyperosmolar conditio