Zobrazeno 1 - 10
of 11
pro vyhledávání: '"TYK2, tyrosine kinase 2"'
Autor:
Rui Sun, Clara Abraham
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 673-697 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Interleukin (IL)23 is a major contributor to inflammatory bowel disease (IBD) pathogenesis and is being pursued as a therapeutic target, both through targeting IL23 alone or in combination with IL12. Unexpected trial outcomes highli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad178b92adfc5ec39a7be2f0f160e40
https://doi.org/10.1016/j.jcmgh.2020.05.007
https://doi.org/10.1016/j.jcmgh.2020.05.007
Autor:
Sabina Semiz
Publikováno v:
Journal of Trace Elements in Medicine and Biology
An increasing evidence suggests that vanadium compounds are novel potential drugs in the treatment of diabetes, atherosclerosis, and cancer. Vanadium has also demonstrated activities against RNA viruses and is a promising candidate for treating acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71bc6d664fd8cc03c2a90929ff0c898c
https://doi.org/10.1016/j.jtemb.2021.126887
https://doi.org/10.1016/j.jtemb.2021.126887
Publikováno v:
The Journal of Biological Chemistry
N-myc-downregulated gene 1 (NDRG1) has potent anti-cancer effects and inhibits cell growth, survival, metastasis, and angiogenesis. Previous studies suggested that NDRG1 is linked to the androgen signaling network, but this mechanistic relationship i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e33581f9dbfbe17c615d55e5392ba6
https://doi.org/10.1016/j.jbc.2021.101414
https://doi.org/10.1016/j.jbc.2021.101414
Publikováno v:
Gene
Graphical abstract A summarized view of recent findings of host proteins interacting with SARS-CoV-2 and genes containing associated variants with COVID-19 susceptibility and severity. The left side of the figure (A) shows host protein interactors (b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729a7d83d94bd58d45ac4fa0ccf9ac4a
http://europepmc.org/articles/PMC8437745
http://europepmc.org/articles/PMC8437745
Autor:
Nobutaka Tsutsu, Shiori Kondo, Keiichiro Mine, Kanako Hirakawa, Yasunobu Yoshikai, Keizo Anzai, Fumiko Kojima, Seiho Nagafuchi, Masae Minami, Akira Okada, Yumi Hibio, Hironori Kurisaki, Shuji Fujimoto, Yasushi Yokogawa
Publikováno v:
EBioMedicine
EBioMedicine, Vol 23, Iss C, Pp 46-51 (2017)
EBioMedicine, Vol 23, Iss C, Pp 46-51 (2017)
Objective Type 1 diabetes (T1D) is known to be caused by Th1 cell-dependent autoimmunity. Recently, we reported that TYK2 promoter variant serves as a putative virus-induced diabetes susceptibility gene associated with deteriorated interferon-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba89f6bbfb05ec31dc78631b7d0c2a1
http://europepmc.org/articles/PMC5605380
http://europepmc.org/articles/PMC5605380
Publikováno v:
Cytokine & Growth Factor Reviews
Interferons (IFN) are key cytokines with multifaceted antiviral and cell-modulatory properties. Three distinct types of IFN are recognized (I-III) based on structural features, receptor usage, cellular source and biological activities. The action of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b33f9602425b8aa361d19eb4ee80b9
http://europepmc.org/articles/PMC7108279
http://europepmc.org/articles/PMC7108279
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 4, Iss 4, Pp 241-247 (2014)
Acta Pharmaceutica Sinica B, Vol 4, Iss 4, Pp 241-247 (2014)
Interferon (IFN) in combination with ribavirin has been the standard of care (SOC) for chronic hepatitis C for the past few decades. Although the current SOC lacks the desired efficacy, and 4 new direct-acting antiviral agents have been recently appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a48b34b744dc874ff4d5273d5887fb
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 5, Iss 1, Pp 245-250 (2015)
FEBS Open Bio, Vol 5, Iss 1, Pp 245-250 (2015)
Highlights • Pseudopotentials of amino acids in a protein predict its photon wavelength emissions. • Spectral power density profiles for each protein in the JAK–STAT pathway converge. • Optimal distance for spectral predictions is between 0.7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538e699feea1e3846c15e4de4439d63e
Autor:
Karbowski LM; Biomolecular Sciences Program, Bioquantum Chemistry Laboratory, Laurentian University , Sudbury, Ontario P3E 2C6, Canada., Murugan NJ; Biomolecular Sciences Program, Bioquantum Chemistry Laboratory, Laurentian University , Sudbury, Ontario P3E 2C6, Canada., Persinger MA; Biomolecular Sciences Program, Bioquantum Chemistry Laboratory, Laurentian University , Sudbury, Ontario P3E 2C6, Canada.
Publikováno v:
FEBS open bio [FEBS Open Bio] 2015 Mar 25; Vol. 5, pp. 245-50. Date of Electronic Publication: 2015 Mar 25 (Print Publication: 2015).
Autor:
Singh S; a Department of Biotherapeutics Research; Boehringer Ingelheim Pharmaceuticals Inc. ; Ridgefield , CT , USA., Kroe-Barrett RR, Canada KA, Zhu X, Sepulveda E, Wu H, He Y, Raymond EL, Ahlberg J, Frego LE, Amodeo LM, Catron KM, Presky DH, Hanke JH
Publikováno v:
MAbs [MAbs] 2015; Vol. 7 (4), pp. 778-91. Date of Electronic Publication: 2015 Apr 23.