Zobrazeno 1 - 10
of 40
pro vyhledávání: '"TXN2"'
Autor:
Yuji Ikeno, Madeline G. Roman, Colton Allen, Gene B. Hubbard, Geneva M. Cunningham, Lisa C. Flores, Christie Cheng, Yidong Bai
Publikováno v:
Aging Pathobiology and Therapeutics. 2:203-209
Background: This study was conducted to test the effects of thioredoxin (Trx)1 down-regulation in Trx2 transgenic [Tg(TXN2) +/0] mice on lifespan and age-related diseases. Our previous study with Tg(TXN2) +/0 mice showed that mitochondrial Trx overex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aba31b3c49d1ded4bc5b7a0842c89b65
https://doi.org/10.31491/apt.2020.12.041
https://doi.org/10.31491/apt.2020.12.041
Autor:
Bi-Rou Zhong, Guojun Chen, Li Song, Biao Luo, Yuanlin Ma, Li-Tian Hu, Gui-Feng Zhou, Qi-Xin Wen, Xiao-Juan Deng, Kun-Yi Li, Xiao-Jiao Xiang, Jian Chen
Publikováno v:
Journal of Neurochemistry. 157:1351-1365
Thioredoxin-2 (TXN2) is a mitochondrial protein and represents one of the intrinsic antioxidant enzymes. It has long been recognized that mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of Alzheimer's disease (AD). We hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2795df268e74b119aadc1623ae2dd830
https://doi.org/10.1111/jnc.15184
https://doi.org/10.1111/jnc.15184
Autor:
Madeline G, Roman, Lisa C, Flores, Geneva M, Cunningham, Christie, Cheng, Sara, Dube, Colton, Allen, Holly, Van Remmen, Yidong, Bai, Gene B, Hubbard, Thomas L, Saunders, Yuji, Ikeno
Publikováno v:
Aging Pathobiology and Therapeutics. 2:20-31
Objective: In this study, the effects of overexpression of thioredoxin 2 (Trx2) on aging and age-related diseases were examined using Trx2 transgenic mice [Tg(TXN2)+/0]. Because our previous studies demonstrated that thioredoxin (Trx) overexpression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4109c52afb3ea8e5e7a9f4fc3d9653
https://doi.org/10.31491/apt.2020.03.009
https://doi.org/10.31491/apt.2020.03.009
Publikováno v:
Molecular Oncology, Vol 14, Iss 2, Pp 329-346 (2020)
Molecular Oncology
Molecular Oncology
Identification of new genetic pathways or molecular targets that sensitize cancer cells to chemotherapeutic drugs may improve the efficacy of current chemotherapy. Here, we report that downmodulation of UHRF1 (ubiquitin‐like with PHD and RING finge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c1b1768a90761b35c68adcb983e6bc
https://doaj.org/article/8c0b5e5dbf4446f8b51da51d77bcd496
https://doaj.org/article/8c0b5e5dbf4446f8b51da51d77bcd496
Akademický článek
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Publikováno v:
Cancer Management and Research. 11:9685-9699
Purpose PRDX (Peroxiredoxin) family has involved in breast cancer tumorigenesis from the evidence obtained from cell lines, human tissues and mouse models. Nonetheless, the diversified expression patterns, coupled with the prognostic values of PRDX f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64bfb2032914a4bda4c9f4b5bd6811e8
https://doi.org/10.2147/cmar.s229389
https://doi.org/10.2147/cmar.s229389
Publikováno v:
The Kurume Medical Journal. 66:15-27
Various endogenous mitochondria-associated antioxidants protect mitochondria from oxidative stresses such as Superoxide Dismutase 2 (SOD2), Catalase, Glutaredoxin 2 (GLRX2), educed Glutathione (GSH), Glutathione Peroxidase (GPx), and Thioredoxin 2 (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e771b14f27f07186bee36e35a95113c9
https://doi.org/10.2739/kurumemedj.ms661009
https://doi.org/10.2739/kurumemedj.ms661009
Autor:
Jiapeng Yang, Kaiyun Yang, Linwei Tian, Guangjian Li, Guangqiang Zhao, Ying Chen, Qinghua Zhou, Zhenghai Shen, Yunchao Huang
Publikováno v:
Journal of Cellular and Molecular Medicine
The Xuanwei area of Yunnan Province, China, is one of the regions suffering from the highest occurrence and mortality rate of lung cancer in the world. Local residents tend to use bituminous coal as domestic fuel, which causes serious indoor air poll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95035b322152b98dda2b913bc3741d79
https://pubmed.ncbi.nlm.nih.gov/34997815
https://pubmed.ncbi.nlm.nih.gov/34997815
Autor:
Salima Metref, Marc Foretz, Simon Quenneville, Davide Basco, Benoit Viollet, Gwenaël Labouèbe, Bernard Thorens
Publikováno v:
Diabetes
Diabetes, American Diabetes Association, 2020, 69 (11), pp.2253-2266. ⟨10.2337/db20-0577⟩
Diabetes, vol. 69, no. 11, pp. 2253-2266
Diabetes, American Diabetes Association, 2020, 69 (11), pp.2253-2266. ⟨10.2337/db20-0577⟩
Diabetes, vol. 69, no. 11, pp. 2253-2266
International audience; The ventromedial nucleus of the hypothalamus (VMN) is involved in the counterregulatory response to hypoglycemia. VMN neurons activated by hypoglycemia (glucose-inhibited [GI] neurons) have been assumed to play a critical alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e0f11d8a54284d5e6eff6978c37217
https://hal.archives-ouvertes.fr/hal-03025465/document
https://hal.archives-ouvertes.fr/hal-03025465/document
Autor:
Maw-Sheng Lee, Chung-Hsien Liu, Tsung-Hsien Lee, Shun-Fa Yang, Cheng-Hsuan Wu, Po-Hui Wang, Long-Yao Lin, Yun-Yao Huang
Publikováno v:
International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 17, Iss 5089, p 5089 (2020)
Volume 17
Issue 14
International Journal of Environmental Research and Public Health, Vol 17, Iss 5089, p 5089 (2020)
Volume 17
Issue 14
It has been reported that oxidative and nitrative stress might be the pathogenesis of endometriosis. This prospective case-control study attempted to check the connection between single nucleotide polymorphism (SNP) of three antioxidant enzymes (glut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580e3b0aaf9f25fde7dd512f40a17a1a
http://europepmc.org/articles/PMC7400372
http://europepmc.org/articles/PMC7400372