Vasoconstrictor antagonism improves functional and structural vascular alterations and liver damage in rats with early NAFLD

Autor: Christophe Casteleyn, Benedicte Y. De Winter, Sven Francque, Luisa Vonghia, Denise van der Graaff, Isabel Pintelon, Joris G. De Man, Jean-Pierre Timmermans, Wilhelmus J. Kwanten, Shivani Chotkoe

Publikováno v: JHEP Reports
JHEP Reports, Vol 4, Iss 2, Pp 100412-(2022)

Background & Aims Intrahepatic vascular resistance is increased in early non-alcoholic fatty liver disease (NAFLD), potentially leading to tissue hypoxia and triggering disease progression. Hepatic vascular hyperreactivity to vasoconstrictors has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d7ccc5a41f528c2d7c72daa5110765
http://europepmc.org/articles/PMC8749167

Diabetes and hypertension: Pivotal involvement of purinergic signaling

Autor: Vera Maria Morsch, Karine Paula Reichert, Milagros Fanny Vera Castro, Naiara Stefanello, Vanessa Valéria Miron, Andréia Machado Cardoso, Maria Rosa Chitolina Schetinger, Charles Elias Assmann, Nathieli B. Bottari

Publikováno v: Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111273-(2021)
Biomedicine & Pharmacotherapy

Graphical abstract
Highlights • The coexistence of diabetes and hypertension represents a major risk factor for the onset of cardiovascular problems. • The purinergic signaling pathway constitutes a ubiquitous system of cell–cell communica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34db00a41121e428fb7b9d4795d39e99
http://www.sciencedirect.com/science/article/pii/S0753332221000585

The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19

Autor: Kritis, Panagiotis, Karampela, Irene, Kokoris, Styliani, Dalamaga, Maria

Publikováno v: Metabolism Open
Metabolism Open, Vol 8, Iss, Pp 100066-(2020)

The coronavirus disease 2019 (COVID-19) pandemic is still ongoing, while no treatment has been proven effective. COVID-19 pathophysiology involves the activation of three main pathways: the inflammatory, the coagulation and the bradykinin cascades. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e232e9ac29bd6e8e9573505bc456ef
https://pubmed.ncbi.nlm.nih.gov/33205039

Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms

Autor: Lu, Ping-Hsun, Tseng, Chien-Wei, Lee, Jing-Ling, Lee, En-Yu, Lin, Yu-Ping, Lin, I-Hsin, Yu, Min-Chien, Lu, Kuo-Cheng, Kuo, Ko-Lin

Publikováno v: Pharmacological Research-Modern Chinese Medicine

Background : SARS-CoV-2 has led to a sharp increase in the number of hospitalizations and deaths from pneumonia and multiorgan disease worldwide; therefore, SARS-CoV-2 has become a global health problem. Supportive therapies remain the mainstay treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2244e4d95e5172a8359236fa899ba577
https://doi.org/10.1016/j.prmcm.2021.100024

The plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease features

Autor: Jeffrey R. Idle, Diren Beyoğlu, Georg Martin Fiedler, Thomas Pabst, Uta Ceglarek, Linda Kortz

Publikováno v: Pabst, Thomas; Kortz, Linda; Fiedler, Georg Martin; Ceglarek, Uta; Idle, Jeffrey; Beyoglu, Diren (2017). The plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease features. BBA clinical, 7, pp. 105-114. Elsevier 10.1016/j.bbacli.2017.03.002
BBA Clinical

Background Early studies established that certain lipids were lower in acute myeloid leukemia (AML) cells than normal leukocytes. Because lipids are now known to play an important role in cell signaling and regulation of homeostasis, and are often pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d3410160f8bd28df0354d9fef3e46d