Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies

Autor: Nathan J Cheetham, Milla Kibble, Andrew Wong, Richard J Silverwood, Anika Knuppel, Dylan M Williams, Olivia KL Hamilton, Paul H Lee, Charis Bridger Staatz, Giorgio Di Gessa, Jingmin Zhu, Srinivasa Vittal Katikireddi, George B Ploubidis, Ellen J Thompson, Ruth CE Bowyer, Xinyuan Zhang, Golboo Abbasian, Maria Paz Garcia, Deborah Hart, Jeffrey Seow, Carl Graham, Neophytos Kouphou, Sam Acors, Michael H Malim, Ruth E Mitchell, Kate Northstone, Daniel Major-Smith, Sarah Matthews, Thomas Breeze, Michael Crawford, Lynn Molloy, Alex SF Kwong, Katie Doores, Nishi Chaturvedi, Emma L Duncan, Nicholas J Timpson, Claire J Steves

Publikováno v: eLife, Vol 12 (2023)

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody levels can be used to assess humoral immune responses following SARS-CoV-2 infection or vaccination, and may predict risk of future infection. Higher levels of SARS-CoV

Externí odkaz: https://doaj.org/article/3b470fcd4a024f3f9f98813d3730e991

Diverging destinies: ‘social’ data within the TwinsUK cohort [version 1; peer review: 2 approved]

Autor: Deborah Hart, Ruth C E Bowyer, Ellen J Thompson, Andrew Anastasiou, Claire J Steves, Jennifer B Dowd, Golboo Abbasian, María Paz García, Genevieve Lachance

Publikováno v: Wellcome Open Research, Vol 7 (2022)

Background: Twins offer social scientists a unique opportunity to understand the interplay of social factors and physical and mental well-being. TwinsUK is the largest UK registry of adult mono- and dy-zygotic twins, but most of the research that uti

Externí odkaz: https://doaj.org/article/964840f6a9b34e639d6b33f54a0288d4

Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches

Autor: Marko Tijardović, Toma Keser, Gordan Lauc, Markus Perola, Tim D. Spector, Olga Gornik, Massimo Mangino, Domagoj Kifer, Cristina Menni, Mario Falchi, Ana Cvetko

Publikováno v: BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)

IntroductionPrediction of type 2 diabetes mellitus (T2DM) and its preceding factors, such as insulin resistance (IR), is of great importance as it may allow delay or prevention of onset of the disease. Plasma protein N-glycome has emerged as a promis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aea09848ecba2b5a91c6e9cc3c3c14b
https://pubmed.ncbi.nlm.nih.gov/34518155

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Cell-type heterogeneity in adipose tissue is associated with complex traits and reveals disease-relevant cell-specific eQTLs

Autor: Craig A. Glastonbury, Alexessander Couto Alves, Kerrin S. Small, Julia S. El-Sayed Moustafa

Publikováno v: American Journal of Human Genetics
Glastonbury, C A, Couto Alves, A, El-Sayed Moustafa, J S & Small, K S 2019, ' Cell-type heterogeneity in adipose tissue is associated with complex traits and reveals disease-relevant cell-specific eQTLs ', American Journal of Human Genetics, vol. 104, no. 6, pp. 1013-1024 . https://doi.org/10.1016/j.ajhg.2019.03.025

Adipose tissue is an important endocrine organ with a role in many cardiometabolic diseases. It is comprised of a heterogeneous collection of cell types that can differentially impact disease phenotypes. Cellular heterogeneity can also confound -omic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7905f50dd7141e92bedf4e660f18b364
https://doi.org/10.1101/283929