Zobrazeno 1 - 10
of 81
pro vyhledávání: '"TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling"'
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 793-803 (2021)
Toxicology Reports, Vol 8, Iss, Pp 793-803 (2021)
Graphical abstract Schematic representation of experimental design in different groups of mothers and offspring. CTL group: control group; Veh group: vehicle group received normal saline; Ni group: nicotine group received 1 mg/kg/day nicotine, subcut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb38e9b71fd2c048e3659853c95de95b
http://europepmc.org/articles/PMC8038947
http://europepmc.org/articles/PMC8038947
Autor:
Suksan Changlek, Walla Alelwani, Arwa A. Makki, Naymul Karim, Mohammad Nasiruddin Rana, Md. Atiar Rahman, Jitbanjong Tangpong, Dina Hajjar
Publikováno v:
Saudi Journal of Biological Sciences, Vol 27, Iss 12, Pp 3700-3710 (2020)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
Graphical abstract
This research investigated the reno-protective effect of Thunbergia laurifolia Linn. (TL) in a lead-induced toxicity test through the modulation of cell signaling pathways. The study carried out to evaluate the effect of TL le
This research investigated the reno-protective effect of Thunbergia laurifolia Linn. (TL) in a lead-induced toxicity test through the modulation of cell signaling pathways. The study carried out to evaluate the effect of TL le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3c30bb34dee77d6b905625f0c3774a
https://doi.org/10.1016/j.sjbs.2020.08.016
https://doi.org/10.1016/j.sjbs.2020.08.016
Autor:
Marie D. Ralff, Benedito A. Carneiro, Lanlan Zhou, Wen-I Chang, Rohinton Tarapore, Varun V. Prabhu, Joshua N. Honeyman, Attila A. Seyhan, Isacco Ferrarini, Alexander G. Raufi, Lindsey Carlsen, Martin Stogniew, Lee Schalop, Robyn Borsuk, Joshua E. Allen, Aakash Jhaveri, Cassandra Parker, Sara Morrow, Young Lee, Fabio Tavora, Wolfgang Oster, Jocelyn E. Ray, Kelsey E. Huntington, Howard Safran, Anna D Louie, Abed Rahman Kawakibi, Yiqun Zhang, Wafik S. El-Deiry
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)
ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G protein coupled receptor (GPCR) dopamine receptor D2 (DRD2), and as an allosteric agon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788cb5d6703ffa407652b681a16c6c03
http://europepmc.org/articles/PMC7588802
http://europepmc.org/articles/PMC7588802
Publikováno v:
Saudi Journal of Biological Sciences, Vol 27, Iss 8, Pp 2174-2184 (2020)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
Testicular torsion and detorsion (TTD) is a serious urological condition affecting young males that is underlined by an ischemia reperfusion injury (tIRI) to the testis as the pathophysiological mechanism. During tIRI, uncontrolled production of oxyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b9b9c3762cf95184a4b635e3a70e69
http://www.sciencedirect.com/science/article/pii/S1319562X20301364
http://www.sciencedirect.com/science/article/pii/S1319562X20301364
Autor:
Monish Ram, Makena, Myungjun, Ko, Allatah X, Mekile, Nanami, Senoo, Donna K, Dang, John, Warrington, Phillip, Buckhaults, C Conover, Talbot, Steven M, Claypool, Rajini, Rao
Publikováno v:
Redox Biology
A complex interplay between the extracellular space, cytoplasm and individual organelles modulates Ca2+ signaling to impact all aspects of cell fate and function. In recent years, the molecular machinery linking endoplasmic reticulum stores to plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7ddcb82bd1cf66a052007667338928d
https://pubmed.ncbi.nlm.nih.gov/35063802
https://pubmed.ncbi.nlm.nih.gov/35063802
Autor:
Jephte Y. Akakpo, Qingyun Bai, Xiao Yang, Li Yang, Thomas Rülicke, Lili Ji, Kurt Zatloukal, Wen-Xing Ding, Hong-Min Ni, Hui Qian, Hartmut Jaeschke
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3791-3805 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3791-3805 (2021)
Acetaminophen (APAP) overdose can induce liver injury and is the most frequent cause of acute liver failure in the United States. We investigated the role of p62/SQSTM1 (referred to as p62) in APAP-induced liver injury (AILI) in mice. We found that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822a9d722ce09297bbb1ac56b38e95ad
https://pubmed.ncbi.nlm.nih.gov/35024307
https://pubmed.ncbi.nlm.nih.gov/35024307
Publikováno v:
Advanced Drug Delivery Reviews
Graphical abstract
Gene therapy has been widely investigated for the treatment of genetic, acquired, and infectious diseases. Pioneering work utilized viral vectors; however, these are suspected of causing serious adverse events, resulting in th
Gene therapy has been widely investigated for the treatment of genetic, acquired, and infectious diseases. Pioneering work utilized viral vectors; however, these are suspected of causing serious adverse events, resulting in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7413733ccbe4eda7411005d2c1ea69
http://europepmc.org/articles/PMC8518240
http://europepmc.org/articles/PMC8518240
Autor:
Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde30b76b24a28a9236a78a6ec2b0a30
https://pubmed.ncbi.nlm.nih.gov/35024303
https://pubmed.ncbi.nlm.nih.gov/35024303
Autor:
Randolph Ruiz Rodriguez, Fumiko Nakazeki, Takeshi Kimura, Chiharu Otani, Yuya Ide, Sijia Xu, Takahiro Horie, Akira Kakizuka, Toshimitsu Watanabe, Koh Ono, Yui Miyasaka, Satoshi Koyama, Yasuhide Kuwabara, Naritatsu Saito, Masamichi Yamamoto, Tomohiro Nishino, Shin Watanabe, Yasuhiro Nakashima, Tomohiro Yamasaki, Masahiro Kimura, Hitoo Nishi, Motoko Yanagita, Masataka Nishiga, Shuhei Tsuji, Tetsushi Nakao
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 701-714 (2019)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • KUS121 was developed to selectively inhibit the adenosine triphosphatase activity of valosin-containing protein without affecting other cellular functions of valosin-containing protein. • KUS121 preserved adenosi
Highlights • KUS121 was developed to selectively inhibit the adenosine triphosphatase activity of valosin-containing protein without affecting other cellular functions of valosin-containing protein. • KUS121 preserved adenosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ca6171c32bb98e41fff95ae5384ca4
http://www.sciencedirect.com/science/article/pii/S2452302X19301822
http://www.sciencedirect.com/science/article/pii/S2452302X19301822
Autor:
Lotteau, S, Ivarsson, N, Yang, Z, Restagno, D, Colyer, J, Hopkins, P, Weightman, A, Himori, K, Yamada, T, Bruton, J, Steele, D, Westerblad, H, Calaghan, S
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • The authors used human and rat muscle to study the mechanism of statin myopathy and its interaction with exercise. • Statin treatment triggered loss of the modulator protein FKBP from the sarcoplasmic reticulum (
Highlights • The authors used human and rat muscle to study the mechanism of statin myopathy and its interaction with exercise. • Statin treatment triggered loss of the modulator protein FKBP from the sarcoplasmic reticulum (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::386d8d164f9f433715b1d7abcc0fcb6c
http://europepmc.org/articles/PMC6712048
http://europepmc.org/articles/PMC6712048