Zobrazeno 1 - 10
of 19 138
pro vyhledávání: '"TUMOR INFILTRATING LYMPHOCYTES"'
Autor:
Juhyeong Park, Soo Kyung Nam, Yoonjin Kwak, Hyeon Jeong Oh, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee, Han-Kwang Yang, Hye Seung Lee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Microsatellite instability-high (MSI-H) gastric cancer (GC) exhibits high tumor-infiltrating lymphocyte (TIL) density. Despite the recognized significance of the immune microenvironment in MSI-H GC, our understanding of TIL remains limited.
Externí odkaz:
https://doaj.org/article/3ae5b3da35ba42e699fe7e2dd928d347
Autor:
Shengnan Yang, Junrong Wang, Zhenwu Du, Chunhua Sheng, Qianyu Liu, Xuewei Lao, Donghui Xu, Ying Pan
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Objective The objective of this study is to develop a novel therapeutic approach for the treatment of ovarian cancer while investigating the role of tumor-infiltrating lymphocytes (TILs) in the context of ovarian cancer therapy. The primary
Externí odkaz:
https://doaj.org/article/7338328e9a284a6c88719f10d6fa9640
Autor:
Yanyan Zhang, Yun Huang, Dianping Yu, Mengting Xu, Hongmei Hu, Qing Zhang, Minchen Cai, Xiangxin Geng, Hongwei Zhang, Jianhua Xia, Mengmeng Guo, Dong Lu, Hanchi Xu, Linyang Li, Xing Zhang, Qun Wang, Sanhong Liu, Weidong Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4312-4328 (2024)
Programmed cell death ligand-1 (PD-L1) is a T cell inhibitory immune checkpoint molecule that interacts with programmed cell death-1 (PD-1) to promote immune escape of tumor cells. Compared with antibody therapies, small molecule drugs show better pr
Externí odkaz:
https://doaj.org/article/a7130bd47bb441cfbc68faa19f780568
Immunomodulatory role of tumor microenvironment on oncological outcomes in advanced laryngeal cancer
Autor:
Anna Rzepakowska, Joanna Olędzka, Piotr Daniel, Marta Mękarska, Michał Żurek, Karol Kulbaka, Łukasz Fus
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background The study evaluated the prognostic impact of the immune microenvironment in LSCC with markers of major immune cells to identify the key determinants of short-term disease-free survival (ST DFS) and reveal factors related to diseas
Externí odkaz:
https://doaj.org/article/b523a5dc63db4a539b5f2018789ead10
Autor:
Anning Zuo, Jinxiang Lv, Wenlong Jia, Yuhao Ba, Shutong Liu, Yuyuan Zhang, Siyuan Weng, Hui Xu, Long Liu, Libo Wang, Xinwei Han, Zaoqu Liu
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Background Tumor-infiltrating lymphocytes (TILs) are significantly implicated in regulating the tumor immune microenvironment (TIME) and immunotherapeutic response. However, little is known about the impact of the resident and exhausted stat
Externí odkaz:
https://doaj.org/article/557d04bf38ae4262b7014cd67332cd7d
Autor:
Esraa Adel Mahmoud Mohamed Atia, Sanaa Abd Elmaged Sammour, Eman Abdel-Salam Ibrahim, Hoda Hassan Abou Gabal, Shimaa Abdelraouf Elgohary
Publikováno v:
The Egyptian Journal of Otolaryngology, Vol 40, Iss 1, Pp 1-11 (2024)
Abstract Background Glycoprotein A repetitions predominant (GARP) is a novel transmembrane protein highly expressed on the surface of regulatory T cells (Tregs), which are a subset of immunosuppressive T lymphocytes that play a major role in inhibiti
Externí odkaz:
https://doaj.org/article/365cf23912ed45cbaba9c07a93e11791
Autor:
Nurkhairul Bariyah Baharun, Afzan Adam, Mohamed Afiq Hidayat Zailani, Nasir M. Rajpoot, Qiaoyi XU, Reena Rahayu Md Zin
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Tumour microenvironment (TME) of breast cancer mainly comprises malignant, stromal, immune, and tumour infiltrating lymphocyte (TILs). Assessment of TILs is crucial for determining the disease’s prognosis. Manual TIL assessments are hamper
Externí odkaz:
https://doaj.org/article/da6cd367228644c7b6e413077cafb088
Autor:
Rokas Stulpinas, Ieva Jakiunaite, Agne Sidabraite, Allan Rasmusson, Dovile Zilenaite-Petrulaitiene, Kestutis Strupas, Arvydas Laurinavicius, Aiste Gulla
Publikováno v:
Current Oncology, Vol 31, Iss 9, Pp 5344-5353 (2024)
Our study included 41 patients fulfilling the Milan criteria preoperatively and aimed to identify individuals at high risk of post-resection HCC relapse, which occurred in 18 out of 41 patients (43.9%), retrospectively. We analyzed whole slide images
Externí odkaz:
https://doaj.org/article/f6b34045679440bd9c94523cef8e69d9
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Based on the joint analysis of multi-omic data and the biological experiments, we demonstrate that FOXF1 inhibits invasion and metastasis of lung adenocarcinoma cells and enhances anti-tumor immunity via regulating MFAP4/FAK signal axis in t
Externí odkaz:
https://doaj.org/article/7b8ca70684864ee9be189757e5711996
Autor:
Ryo Kanoda, Shotaro Nakajima, Satoshi Fukai, Motonobu Saito, Katsuharu Saito, Hiroya Suzuki, Tomohiro Kikuchi, Azuma Nirei, Hirokazu Okayama, Kosaku Mimura, Hiroyuki Hanayama, Wataru Sakamoto, Tomoyuki Momma, Zenichiro Saze, Koji Kono
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) gastric cancer (GC) exhibits an immune-active tumor microenvironment (TME) compared to MMR proficient (pMMR)/microsatellite stable/Epstein-Barr virus-negative [EBV (−
Externí odkaz:
https://doaj.org/article/57decaa1a5db4788a29f6759405f3d95