Zobrazeno 1 - 10
of 1 191
pro vyhledávání: '"TUMOR EVOLUTION"'
Autor:
Tingjie Wang, Lingxi Tian, Bing Wei, Jun Li, Cuiyun Zhang, Ruitao Long, Xiaofei Zhu, Yougai Zhang, Bo Wang, Guangbo Tang, Jun Yang, Yongjun Guo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Tumor heterogeneity is associated with poor prognosis and drug resistance, leading to therapeutic failure. Here, we used tumor evolution analysis to determine the intra- and intertumoral heterogeneity of high-grade serous ovarian cancer (HGS
Externí odkaz:
https://doaj.org/article/03f94c1274544b01b09a80e388bb034c
Autor:
Thale K. Olsen, Jörg Otte, Shenglin Mei, Bethel Tesfai Embaie, Polina Kameneva, Huaitao Cheng, Teng Gao, Vasilios Zachariadis, Ioanna Tsea, Åsa Björklund, Emil Kryukov, Ziyi Hou, Anna Johansson, Erik Sundström, Tommy Martinsson, Susanne Fransson, Jakob Stenman, Shahrzad Shirazi Fard, John Inge Johnsen, Per Kogner, Igor Adameyko, Martin Enge, Peter V. Kharchenko, Ninib Baryawno
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Neuroblastoma (NB) is a heterogeneous embryonal malignancy and the deadliest tumor of infancy. It is a complex disease that can result in diverse clinical outcomes. In some children, tumors regress spontaneously. Others respond we
Externí odkaz:
https://doaj.org/article/1d5da37f62bb4e9c8494a94bf33d81b4
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Glioblastoma (GBM) is the most common malignant brain tumor and has a dismal prognosis even under the current first-line treatment, with a 5-year survival rate less than 7%. Therefore, it is important to understand the mechanism of treatment
Externí odkaz:
https://doaj.org/article/779856a2e1d140eaaa016ecc68d920a9
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Cancers are spatially heterogenous, thus their clonal evolution, especially following anti-cancer treatments, depends on where the mutated cells are located within the tumor tissue. For example, cells exposed to different concentr
Externí odkaz:
https://doaj.org/article/c5b39ee40d63426db1a417f59d4011d5
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 3919-3942 (2024)
Wenshe Sun,1– 3,* Shaowei Xie,4,* Shi Feng Liu,1,* Xiaokun Hu,1 Dongming Xing1,2 1The Affiliated Hospital of Qingdao University, Qingdao, 266071, People’s Republic of China; 2Qingdao Cancer Institute, Qingdao University, Qingdao, 2660
Externí odkaz:
https://doaj.org/article/b658722fb4c14c8c905aa09712dc6bbe
Autor:
Mariangela Russo
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 241-244 (2024)
Drug resistance represents a major limitation to the long‐term efficacy of anti‐cancer treatments. The commonly accepted view is that the selection of inheritable genetic mechanisms governs the development of secondary resistance. However, compel
Externí odkaz:
https://doaj.org/article/b22c5c49e04042bb8d19f823b8c005b9
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Akademický článek
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Publikováno v:
Heliyon, Vol 10, Iss 6, Pp e27733- (2024)
Extrachromosomal DNAs (ecDNAs) are a pervasive feature found in cancer and contain oncogenes and their corresponding regulatory elements. Their unique structural properties allow a rapid amplification of oncogenes and alter chromatin accessibility, l
Externí odkaz:
https://doaj.org/article/672bee21b6554527b2256e4e820b0ec4
Autor:
Pavel Vladimirovich NIKITIN, Guzel Railevna MUSINA, Valery Nikolaevich POLOZOV, Dmitry Nikolaevich GOREIKO, Vladimir Mikhailovich KRASNOVSKY, Leonard WERKENBARK, Mauric KJELIN, Piotr Sergeevich TIMASHEV,,
Publikováno v:
Türk Patoloji Dergisi, Vol 39, Iss 2, Pp 117-132 (2023)
Objective: IDH wild-type glioblastomas (GBM) are one of the most malignant and complex tumors for treatment. The urgent question of new therapeutic and diagnostic tools searching should be resolved based on cellular and molecular pathogenesis mechani
Externí odkaz:
https://doaj.org/article/2c1a01c3aad140fe8b143c8e953fdbcc