Zobrazeno 1 - 10
of 2 863
pro vyhledávání: '"TUBULIN POLYMERIZATION"'
Publikováno v:
Shipin gongye ke-ji, Vol 45, Iss 16, Pp 85-93 (2024)
To examine the regulatory mechanisms of oligopeptides derived from soft-shelled turtle protein on tubulin activity in tumor cells, this study employed three specific oligopeptides D-7-A, E-7-W, and G-8-V obtained from soft-shelled turtle protein. The
Externí odkaz:
https://doaj.org/article/0f224eea98a84d9e8739b95bbabef391
Biological Profile of Synthetic and Natural Indole Derivatives: Paving New Paths in Cancer Treatment
Publikováno v:
Drugs and Drug Candidates, Vol 3, Iss 3, Pp 488-511 (2024)
The indole scaffold is considered a privileged framework in the design and synthesis of several active pharmaceutical ingredients, particularly as promising anticancer agents. Its presence in several bioactive natural compounds has caught the attenti
Externí odkaz:
https://doaj.org/article/78de1831557a4ad2ad40e4e34d067dca
Publikováno v:
BMC Microbiology, Vol 24, Iss 1, Pp 1-22 (2024)
Abstract Epothilone derivatives have been recognized as one of the most powerful anticancer drugs towards solid tumors, for their unique affinity to bind with β-tubulin microtubule arrays, stabilizing their disassembly, causing cell death. Sornagium
Externí odkaz:
https://doaj.org/article/1343bdba233749bc8198e2a5db746264
Autor:
Hung-Yu Lin, Tsen-Ni Tsai, Kai-Cheng Hsu, Yu-Ming Hsu, Lin-Chien Chiang, Mohamed El-Shazly, Ken-Ming Chang, Yu-Hsuan Lin, Shang-Yi Tu, Tony Eight Lin, Ying-Chi Du, Yi-Chang Liu, Mei-Chin Lu
Publikováno v:
Marine Drugs, Vol 22, Iss 7, p 323 (2024)
Marine natural products offer immense potential for drug development, but the limited supply of marine organisms poses a significant challenge. Establishing aquaculture presents a sustainable solution for this challenge by facilitating the mass produ
Externí odkaz:
https://doaj.org/article/06e5b0f350b54c1aadff47f1f180258b
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 8, Pp 6272-6282 (2023)
Avermectins are a group of macrocyclic lactones that are commonly used as pesticides to treat pests and parasitic worms. Some members of the avermectin family, such as ivermectin, have been found to exhibit anti-proliferative activity toward cancer c
Externí odkaz:
https://doaj.org/article/1f58233cd425498eb1ee535d70d1d133
Autor:
Yingying Tian, Ailin Yang, Huiming Huang, Jinxin Xie, Longyan Wang, Dongxiao Liu, Xuejiao Wei, Peng Tan, Pengfei Tu, Dongjun Fu, Zhongdong Hu
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 2, Pp 105550- (2024)
Hepatocellular carcinoma (HCC) is a major global cause of carcinoma-related fatality. The inhibition of tubulin polymerization holds significant potential in the development of cancer drugs. In our study, we synthesized a novel pyrrolidine-2,5-dione
Externí odkaz:
https://doaj.org/article/233dc90ca6da49c782bc5eb374252ad8
Autor:
Denitsa Yancheva, Maria Argirova, Irina Georgieva, Vanya Milanova, Maya Guncheva, Miroslav Rangelov, Nadezhda Todorova, Rumiana Tzoneva
Publikováno v:
Molecules, Vol 29, Iss 10, p 2400 (2024)
(1) Background: The aim of the work is the evaluation of in vitro antiproliferative and pro-apoptotic activity of four benzimidazole derivatives containing colchicine-like and catechol-like moieties with methyl group substitution in the benzimidazole
Externí odkaz:
https://doaj.org/article/a92ac4c02fa04138847d7d3934b2f048
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 10, Pp 105146- (2023)
Some novel 4-aryl-9H-carbazoles were designed as potential tubulin polymerization inhibitors through structural optimization and bioisosteric strategy. These compounds showed effective antiproliferative activities against a diverse set of cancer cell
Externí odkaz:
https://doaj.org/article/fef20283db844083b3465c663f87a13c
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