Zobrazeno 1 - 10
of 52
pro vyhledávání: '"TTX, tetrodotoxin"'
Autor:
Aimee G Kim, Melissa N. Orr, Robert O. Heuckeroth, Kendall M. Lawrence, Haiying Li, Heron D. Baumgarten, William H. Peranteau, Marcus G. Davey, Grace Hwang, Ali Y. Mejaddam, Lauren J. Brown, Christina M. Wright, Alan W. Flake, Barbara E. Coons, Zoya Butt, Patrick E. McGovern, Ronald C. Rubenstein, Avery C. Rossidis, Antoneta Radu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 623-637 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 623-637 (2020)
Background and Aims The Extra-Uterine Environment for Neonatal Development (EXTEND) aims to avoid the complications of prematurity, such as NEC. Our goal was to determine if bowel development occurs normally in EXTEND-supported lambs, with specific e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e844cee198714a018c7bd1873f98d86e
https://doi.org/10.1016/j.jcmgh.2020.05.006
https://doi.org/10.1016/j.jcmgh.2020.05.006
Publikováno v:
Neurobiology of Pain, Vol 11, Iss, Pp 100082-(2022)
Neurobiology of Pain
Neurobiology of Pain
Highlights • NaV1.7 is a prized pain target for which few drugs exist. • Allosteric regulation of NaV1.7 via the interacting protein CRMP2 is antinociceptive. • Small molecule 194, which blocks CRMP2 SUMOylation, decreases NaV1.7 to achieve ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0236138d6c1cd3053d94b10d523c4714
http://www.sciencedirect.com/science/article/pii/S2452073X21000234
http://www.sciencedirect.com/science/article/pii/S2452073X21000234
Autor:
Hiroshi Yamada, Ryo Taiji, Shunji Tsutsui, Terumasa Nakatsuka, Naoko Nishio, Wataru Taniguchi, Manabu Yamanaka
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101130-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Riluzole (2-amino-6-(trifluoromethoxy)benzothiazole) is a drug known for its inhibitory effect on glutamatergic transmission and its anti-nociceptive and anti-allodynic effects in neuropathic pain rat models. Riluzole also has an enhancing effect on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d3549535d30d1ec684d846de041289
http://www.sciencedirect.com/science/article/pii/S2405580821002247
http://www.sciencedirect.com/science/article/pii/S2405580821002247
Autor:
Zhenyi Li, Yali Wang, Sanya Ahmed, Martin Vreugdenhil, Yujiao Zhang, Jianbin Wen, Georgiana Neagu, Chunjie Liu
Publikováno v:
IBRO Reports
IBRO Reports, Vol 6, Iss, Pp 122-131 (2019)
IBRO Reports, Vol 6, Iss, Pp 122-131 (2019)
Highlights • CA3 gamma oscillation (γ) drives CA1 gamma and suppresses CA1 intrinsic fast γ. • μ-opioid receptor (MOR) activation reduces γ frequency in CA3 and CA1. • MOR activation in CA1 phase-uncouples CA1 γ from CA3 γ. • Uncoupling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8867c275a463eabf2fe3c82f772d7b
https://doi.org/10.1016/j.ibror.2019.01.004
https://doi.org/10.1016/j.ibror.2019.01.004
Autor:
Daijiro Chiba, Yuka Jinno, Måns Aspåker, Natsuki Eguchi, Masaki Hashimoto, Risa Mori-Kreiner, Atsuo Nishino, Takafumi Kawai, Junko M. Nishino, Akira Kawanabe, Yukio Ohtsuka, Yasushi Okamura
Publikováno v:
The Journal of Biological Chemistry
Voltage-gated sodium channels (Nav1s) are responsible for the initiation and propagation of action potentials in neurons, muscle, and endocrine cells. Many clinically used drugs such as local anesthetics and antiarrhythmics inhibit Nav1s, and a varie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9518a87f22f41224fcbde20eff4edff
http://europepmc.org/articles/PMC8192821
http://europepmc.org/articles/PMC8192821
Autor:
Timothy F. Osborne, Elnaz Karimian Azari, Paula P Veldhuis, Traci E. LaMoia, Richard E. Pratley, Veronika Vargova, Kathleen R. Smith, Juan Pablo Arnoletti, Sebastian G. de la Fuente, Katalin Karolyi, Tania Hussain, George Kyriazis
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 17, Iss, Pp 98-111 (2018)
Molecular Metabolism, Vol 17, Iss, Pp 98-111 (2018)
Objective Beyond the taste buds, sweet taste receptors (STRs; T1R2/T1R3) are also expressed on enteroendocrine cells, where they regulate gut peptide secretion but their regulatory function within the intestine is largely unknown. Methods Using T1R2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9872398a06c983e36404d615b501e9ec
http://europepmc.org/articles/PMC6197762
http://europepmc.org/articles/PMC6197762
Autor:
Emma V. Bird, Veselin I. Andreev, Anne King, Claire R. Christmas, Fiona M. Boissonade, Ilona Obara, Tommaso Iannitti
Publikováno v:
Neuroscience
Highlights • We identified XCR1 in the peripheral and central nervous systems and demonstrated its upregulation following nerve injury. • In injured nerve, XCR1 is present in nerve fibers, CD45-positive leucocytes and Schwann cells. • In Vc, XC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bcb4a7cea2f85b2d557bea86bf7c0e
https://doi.org/10.1016/j.neuroscience.2018.03.030
https://doi.org/10.1016/j.neuroscience.2018.03.030
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 10, Iss C, Pp 145-151 (2017)
Biochemistry and Biophysics Reports, Vol 10, Iss C, Pp 145-151 (2017)
Although the endocrine disruptor bisphenol A (BPA) is reported to inhibit nerve conduction, the underlying mechanisms are unclear. Therefore, in the present study, we examined the effect of BPA on compound action potentials (CAPs) recorded from the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5924bc55099daafd268a18d55c2f91
https://doi.org/10.1016/j.bbrep.2017.03.006
https://doi.org/10.1016/j.bbrep.2017.03.006
Autor:
Salaun, Christine, Ritchie, Louise, Greaves, Jennifer, Bushell, Trevor J., Chamberlain, Luke H.
Publikováno v:
Molecular and Cellular Neurosciences
The S-acyltransferase zDHHC2 mediates dynamic S-acylation of PSD95 and AKAP79/150, which impacts synaptic targeting of AMPA receptors. zDHHC2 is responsive to synaptic activity and catalyses the increased S-acylation of PSD95 that occurs following ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2e53e1224bd6c043f7ca53b49bce73e9
http://europepmc.org/articles/PMC5711357
http://europepmc.org/articles/PMC5711357
Autor:
Shu Fun Josephine Ng, Jack H. Howden, Christopher E. Bope, Miguel A. Rodriguez Santos, Jake S. Dengler, Matt R. Kelley, Qiu Ren, Paul Davies, Ross A. Cardarelli, Catherine Choi, Josef T. Kittler, Joshua L. Smalley, Stephen J. Moss, Georgina Kontou, Nicholas J. Brandon
Publikováno v:
The Journal of Biological Chemistry
The K+/Cl− cotransporter KCC2 (SLC12A5) allows mature neurons in the CNS to maintain low intracellular Cl− levels that are critical in mediating fast hyperpolarizing synaptic inhibition via type A γ-aminobutyric acid receptors (GABAARs). In acco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99424a7f43e3b1d015f02bb407fe0519
https://doi.org/10.1016/j.jbc.2021.100364
https://doi.org/10.1016/j.jbc.2021.100364