Zobrazeno 1 - 4
of 4
pro vyhledávání: '"TT Wlodkowski"'
Autor:
Olaf Riess, M Michaud, Bernd J. Pichler, LE Clemens, R Pruss, Jonasz J. Weber, Schamim H. Eckert, Janett Eckmann, Carsten Calaminus, Libo Yu-Taeger, TT Wlodkowski, Andreas Weiss, H Phuc Nguyen, Nicolas Casadei, Jcd Magg, Thierry Bordet, Gunter P. Eckert
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry 85(Suppl 1), A96-A96 (2014). doi:10.1136/jnnp-2014-309032.278
Background Proteolytic cleavage of the mutant huntingtin protein (mHtt) leads to toxic N-terminal mHtt fragments, which are known to disrupt mitochondrial function. Olesoxime, a small cholesterol-like molecule, targets mitochondria and has demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f86f00ca5171a184e4a4df18b5150b
https://doi.org/10.1136/jnnp-2014-309032.278
https://doi.org/10.1136/jnnp-2014-309032.278
Autor:
E Portal, M Michaud, Olaf Riess, Schamim H. Eckert, Janett Eckmann, L Yu, LE Clemens, Huu P. Nguyen, Thierry Bordet, TT Wlodkowski, Gunter P. Eckert, R Pruss
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 83:A53.3-A54
Background Olesoxime, a cholesterol-oxime, is a neuroprotective compound initially developed for the treatment of ALS (Bordet et al 2007). It interacts with proteins on the outer membrane of mitochondria (OMM) and inhibits the opening of the mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5cc021ac5dea88c1fc4817214569373
https://doi.org/10.1136/jnnp-2012-303524.168
https://doi.org/10.1136/jnnp-2012-303524.168
Autor:
Eich G; Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany., Bartosova M; Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany., Tischer C; The European Molecular Biology Laboratory, Heidelberg, Germany., Wlodkowski TT; Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany., Schaefer B; Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany., Pichl S; Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany., Kraewer N; Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany., Ranchin B; Service de Néphrologie Pédiatrique, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, France., Vondrak K; Department of Pediatrics, University Hospital Motol, Prague, Czech Republic., Liebau MC; Pediatric Nephrology, Department of Pediatrics and Center for Molecular Medicine, University Hospital of Cologne, Cologne, Germany., Hackert T; Department of Surgery, University Hospital Heidelberg, Heidelberg, Germany., Schmitt CP; Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Publikováno v:
PloS one [PLoS One] 2017 Dec 18; Vol. 12 (12), pp. e0189903. Date of Electronic Publication: 2017 Dec 18 (Print Publication: 2017).
Autor:
Clemens LE; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany., Weber JJ; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany., Wlodkowski TT; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany., Yu-Taeger L; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany., Michaud M; 3 Trophos SA., Parc Scientifique de Luminy Case 931, 13288 Marseille Cedex 9, France., Calaminus C; 4 Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Roentgenweg 13, 72076 Tuebingen, Germany., Eckert SH; 5 Department of Pharmacology, Goethe University Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt, Germany., Gaca J; 5 Department of Pharmacology, Goethe University Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt, Germany., Weiss A; 6 Novartis Institutes for BioMedical Research, Klybeckstrasse 141, 4057 Basel, Switzerland., Magg JC; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany., Jansson EK; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany., Eckert GP; 5 Department of Pharmacology, Goethe University Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt, Germany., Pichler BJ; 4 Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Roentgenweg 13, 72076 Tuebingen, Germany., Bordet T; 3 Trophos SA., Parc Scientifique de Luminy Case 931, 13288 Marseille Cedex 9, France., Pruss RM; 3 Trophos SA., Parc Scientifique de Luminy Case 931, 13288 Marseille Cedex 9, France., Riess O; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany., Nguyen HP; 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany hoa.nguyen@med.uni-tuebingen.de.
Publikováno v:
Brain : a journal of neurology [Brain] 2015 Dec; Vol. 138 (Pt 12), pp. 3632-53. Date of Electronic Publication: 2015 Oct 21.