Výsledky vyhledávání - "TSPO (18 kda translocator protein)"

Akademický článek

Sex-driven variability in TSPO-expressing microglia in MS patients and healthy individuals

Autor: Sini Laaksonen, Maija Saraste, Marjo Nylund, Rainer Hinz, Anniina Snellman, Juha Rinne, Markus Matilainen, Laura Airas

Publikováno v: Frontiers in Neurology, Vol 15 (2024)

BackgroundMales with multiple sclerosis (MS) have a higher risk for disability progression than females, but the reasons for this are unclear.ObjectiveWe hypothesized that potential differences in TSPO-expressing microglia between female and male MS

Externí odkaz: https://doaj.org/article/bb2c25aefce34018ae3df5e06f9c47e6

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Akademický článek

Assessing organ-level immunoreactivity in a rat model of sepsis using TSPO PET imaging

Autor: Neysha Martinez-Orengo, Sarine Tahmazian, Jianhao Lai, Zeping Wang, Sanhita Sinharay, William Schreiber-Stainthorp, Falguni Basuli, Dragan Maric, William Reid, Swati Shah, Dima A. Hammoud

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

There is current need for new approaches to assess/measure organ-level immunoreactivity and ensuing dysfunction in systemic inflammatory response syndrome (SIRS) and sepsis, in order to protect or recover organ function. Using a rat model of systemic

Externí odkaz: https://doaj.org/article/2512f36b07e448e9b9e028795ea14033

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Akademický článek

Comparative Assessment of TSPO Modulators on Electroencephalogram Activity and Exploratory Behavior

Autor: Rochelle M. Hines, Elaine A. Aquino, Matthew I. Khumnark, Maria P. Dávila, Dustin J. Hines

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Network communication in the CNS relies upon multiple neuronal and glial signaling pathways. In addition to synaptic transmission, other organelles such as mitochondria play roles in cellular signaling. One highly conserved mitochondrial signaling me

Externí odkaz: https://doaj.org/article/e30fea4d836d42d8855c0d6532d9deb0

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Akademický článek

ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease – Study Protocol and Baseline Characteristics

Autor: Anniina Snellman, Laura L. Ekblad, Mikko Koivumäki, Noora Lindgrén, Jouni Tuisku, Merja Perälä, Lila Kallio, Riina Lehtonen, Virva Saunavaara, Jani Saunavaara, Vesa Oikonen, Richard Aarnio, Eliisa Löyttyniemi, Riitta Parkkola, Mira Karrasch, Henrik Zetterberg, Kaj Blennow, Juha O. Rinne

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

BackgroundDetailed characterization of early pathophysiological changes in preclinical Alzheimer's disease (AD) is necessary to enable development of correctly targeted and timed disease-modifying treatments. ASIC-E4 study (“Beta-Amyloid, Synaptic

Externí odkaz: https://doaj.org/article/1fb4379f44584a3c8dca82e7d8965833

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Akademický článek

Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An in vivo PET Study With Neuropathological Comparison

Autor: Paul Wright, Mattia Veronese, Ndabezinhle Mazibuko, Federico E. Turkheimer, Eugenii A. Rabiner, Clive G. Ballard, Steven C. R. Williams, Avinash Kumar Hari Narayanan, Bahiya Osrah, Ricky Williams, Tiago R. Marques, Oliver D. Howes, Federico Roncaroli, Michael J. O'Sullivan

Publikováno v: Frontiers in Neurology, Vol 11 (2020)

Small vessel disease (SVD) is associated with cognitive impairment in older age and be implicated in vascular dementia. Post-mortem studies show proliferation of activated microglia in the affected white matter. However, the role of inflammation in S

Externí odkaz: https://doaj.org/article/29e9fbcaf5e44f6bb48a11cbfb8b5dc5

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PET Imaging of Neuroinflammation in Alzheimer's Disease

Autor: Rong, Zhou, Bin, Ji, Yanyan, Kong, Limei, Qin, Wuwei, Ren, Yihui, Guan, Ruiqing, Ni

Publikováno v: Frontiers in Immunology

Neuroinflammation play an important role in Alzheimer’s disease pathogenesis. Advances in molecular imaging using positron emission tomography have provided insights into the time course of neuroinflammation and its relation with Alzheimer’s dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ecf99ff3895adcabded9044f77890924
https://pubmed.ncbi.nlm.nih.gov/34603323

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PET Imaging of Neuroinflammation in Alzheimer's Disease

Autor: Zhou, Rong, Ji, Bin, Kong, Yanyan, Qin, Limei, Ren, Wuwei, Guan, Yihui, Ni, Ruiqing

Publikováno v: Frontiers in Immunology, 12

Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in molecular imaging using positron emission tomography have provided insights into the time course of neuroinflammation and its relation with Alzheimer's disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ee4d65b9c5168556250e106f188728

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