Zobrazeno 1 - 10
of 54
pro vyhledávání: '"TSA, trichostatin A"'
Autor:
Andrew M. Piggott, Samantha J. Emery-Corbin, Daniel Vuong, Aaron R. Jex, Ernest Lacey, Alexander Y.F. Lam
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss, Pp 68-80 (2021)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
Trichomonas vaginalis is a neglected urogenital parasitic protist that causes 170 million cases of trichomoniasis annually, making it the most prevalent non-viral, sexually transmitted disease. Trichomoniasis treatment relies on nitroheterocyclics, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1638caa9d9810a926a7ef989e12ee1
https://doi.org/10.1016/j.ijpddr.2021.01.001
https://doi.org/10.1016/j.ijpddr.2021.01.001
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 391-418 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims The miR-34a gene is a direct target of p53 and is commonly silenced in colorectal cancer (CRC). Here we identified the receptor tyrosine kinase CSF1R as a direct miR-34a target and characterized CSF1R as an effector of p53/miR-34a-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd6f32982ca09e25e86801417a279b4
http://www.sciencedirect.com/science/article/pii/S2352345X20300461
http://www.sciencedirect.com/science/article/pii/S2352345X20300461
Autor:
Tram Anh Tran, Qing-Jun Zhang, Lei Wang, Christopher Gonzales, Luc Girard, Herman May, Thomas Gillette, Zhi-Ping Liu, Elisabeth D. Martinez
Publikováno v:
The Journal of Biological Chemistry
Hypertrophic/dilated cardiomyopathy, often a prequel to heart failure, is accompanied by maladaptive transcriptional changes that contribute to arrythmias and contractile misfunction. Transgenic mice constitutively expressing high levels of calcineur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112f854788555475bb177a80293d9bd2
https://pubmed.ncbi.nlm.nih.gov/34933013
https://pubmed.ncbi.nlm.nih.gov/34933013
Autor:
Jiemin Wong, Yuanyong Huang, Qingqing Guan, Jiwen Li, Li Kang, Xiaoya Duan, Lan Fang, Zhen Wang, Yimei Sun, Qiao Zhang
Publikováno v:
The Journal of Biological Chemistry
Sox2 (SRY-box 2) is a transcription factor with critical roles in maintaining embryonic and adult stem cell functions and in tumorigenesis. However, how Sox2 exerts its transcriptional function remains unclear. Here we used an in vitro protein-protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc871e08c423a1d049bce37de141753
http://europepmc.org/articles/PMC8668987
http://europepmc.org/articles/PMC8668987
Publikováno v:
The Journal of Biological Chemistry
Histone deacetylase 3 (HDAC3) plays an important role in signal-dependent transcription and is dysregulated in diseases such as cancer. Previous studies have shown that the function of HDAC3 requires an activation step, which is mediated by the inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c2fa0a0fef5e2df0798785326bc631
http://europepmc.org/articles/PMC8502911
http://europepmc.org/articles/PMC8502911
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 880-901 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 880-901 (2019)
The trend toward designing large hydrophobic molecules for lead optimization is often associated with poor drug-likeness and high attrition rates in drug discovery and development. Structural simplification is a powerful strategy for improving the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb376b89b70d546819c6896fcd6d927
https://doi.org/10.1016/j.apsb.2019.05.004
https://doi.org/10.1016/j.apsb.2019.05.004
Autor:
Bernhard Biersack
Publikováno v:
Non-coding RNA Research, Vol 3, Iss 4, Pp 161-173 (2018)
Non-coding RNA Research
Non-coding RNA Research
Malignant mesothelioma diseases feature an increasing risk due to their severe forms and their association with asbestos exposure. Platinum(II) complexes such as cisplatin and carboplatin are clinically approved for the therapy of mesothelioma often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cf66f02600358bbd458691c22858d9
http://www.sciencedirect.com/science/article/pii/S2468054018300763
http://www.sciencedirect.com/science/article/pii/S2468054018300763
Autor:
Mengxue Zhang, Go Urabe, Christopher Little, Lian-Wang Guo, Yitao Huang, Alycia Kent, Bowen Wang, K. Craig Kent
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 782-795 (2018)
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 782-795 (2018)
Visual Abstract
Highlights • Distinct from other histone deacetylases, HDAC6 primarily resides in the cytosol. • Unexpectedly, HDAC6-selective inhibition (or silencing) enhances the nuclear activity of SRF. • HDAC6 inhibition elevates acet
Highlights • Distinct from other histone deacetylases, HDAC6 primarily resides in the cytosol. • Unexpectedly, HDAC6-selective inhibition (or silencing) enhances the nuclear activity of SRF. • HDAC6 inhibition elevates acet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88948908b31bd909f037f62bf67192c
http://europepmc.org/articles/PMC6314972
http://europepmc.org/articles/PMC6314972
Autor:
Michelangelo Foti, Olivia Bejuy, Christine Maeder, Marta Correia de Sousa, Monika Gjorgjieva, Claudio De Vito, Laura Rubbia-Brandt, Dobrochna Dolicka, Margot Fournier, Cyril Sobolewski, Didier J. Colin, Flavien Berthou, Perry J. Blackshear
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology (2020)
Cellular and Molecular Gastroenterology and Hepatology (2020)
Background & Aims Tristetraprolin (TTP) is a key post-transcriptional regulator of inflammatory and oncogenic transcripts. Accordingly, TTP was reported to act as a tumor suppressor in specific cancers. Herein, we investigated how TTP contributes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04acdfadc7dd7cf24b47a30be60cc1a
https://pubmed.ncbi.nlm.nih.gov/32987153
https://pubmed.ncbi.nlm.nih.gov/32987153
Autor:
Bernhard Biersack
Publikováno v:
Non-coding RNA Research
Non-coding RNA Research, Vol 3, Iss 4, Pp 213-225 (2018)
Non-coding RNA Research, Vol 3, Iss 4, Pp 213-225 (2018)
Gemcitabine and pemetrexed are clinically approved antimetabolites for the therapy of mesothelioma diseases. These drugs are often applied in combination with platinum complexes and other drugs. The activity of antimetabolites depended on the express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4aef9ba27f26bc625d6368297e1e44
http://europepmc.org/articles/PMC6257890
http://europepmc.org/articles/PMC6257890