Výsledky vyhledávání - "TRYPTOPHAN HYDROXYLASE-2 (TPH2)"

Akademický článek

Predation Stress Causes Excessive Aggression in Female Mice with Partial Genetic Inactivation of Tryptophan Hydroxylase-2: Evidence for Altered Myelination-Related Processes

Autor: Evgeniy Svirin, Ekaterina Veniaminova, João Pedro Costa-Nunes, Anna Gorlova, Aleksei Umriukhin, Allan V. Kalueff, Andrey Proshin, Daniel C. Anthony, Andrey Nedorubov, Anna Chung Kwan Tse, Susanne Walitza, Lee Wei Lim, Klaus-Peter Lesch, Tatyana Strekalova

Publikováno v: Cells, Vol 11, Iss 6, p 1036 (2022)

The interaction between brain serotonin (5-HT) deficiency and environmental adversity may predispose females to excessive aggression. Specifically, complete inactivation of the gene encoding tryptophan hydroxylase-2 (Tph2) results in the absence of n

Externí odkaz: https://doaj.org/article/1d928175d94c41c88d9ce9c1c27ddaf2

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Akademický článek

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Stress -induced aggression in heterozygous TPH2 mutant mice is associated with alterations in serotonin turnover and expression of 5-HT6 and AMPA subunit 2A receptors

Autor: Allan V. Kalueff, Natalia Bazhenova, Ekaterina Veniaminova, Daniel C. Anthony, Klaus-Peter Lesch, Anna Gorlova, Andrey Proshin, G. Ortega, Tatyana Strekalova, Jonas Waider

Publikováno v: Journal of Affective Disorders, 272, 440-451. Elsevier
Journal of Affective Disorders

Background: The contribution of gene-environment interactions that lead to excessive aggression is poorly understood. Environmental stressors and mutations of the gene encoding tryptophan hydroxylase-2 (TPH2) are known to influence aggression. For ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a6bc81796f91ca5d7de4bc08360e3a
https://doi.org/10.1016/j.jad.2020.04.014

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REVERSE phenotyping—Can the phenotype following constitutive Tph2 gene inactivation in mice be transferred to children and adolescents with and without adhd?

Autor: Akhrif, Atae, Roy, Arunima, Peters, Katharina, Lesch, Klaus‐Peter, Romanos, Marcel, Schmitt‐Böhrer, Angelika, Neufang, Susanne

Publikováno v: Brain and Behavior, Vol 11, Iss 5, Pp n/a-n/a (2021)
Brain and Behavior, 11(5):e02054. John Wiley & Sons Inc.
Brain and Behavior

Introduction Experimental models of neuropsychiatric disorders, for example, ADHD, are used to mimic specific phenotypic traits of a complex human disorder. However, it remains unresolved to what extent the animal phenotype reflects the specific huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::200977d5b7da58910606161afac693cc
https://doaj.org/article/b7726cf528804cab8a2e50aa7b6ee12b

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Altered behaviour, dopamine and norepinephrine regulation in stressed mice heterozygous in TPH2 gene

Autor: Anna Gorlova, Igor Pomytkin, Allan V. Kalueff, Tatyana Strekalova, Evgeniy Svirin, Daniel C. Anthony, Klaus-Peter Lesch, Angelika G. Schmitt-Boehrer, Raymond Cespuglio, Jonas Waider

Publikováno v: Progress in Neuro-Psychopharmacology & Biological Psychiatry, 108:110155. Elsevier Science
Prog. Neuro-Psychopharmacol. Biol. Psychiatry
Progress in Neuro-Psychopharmacology and Biological Psychiatry

Gene-environment interaction (GxE) determines the vulnerability of an individual to a spectrum of stress-related neuropsychiatric disorders. Increased impulsivity, excessive aggression, and other behavioural characteristics are associated with varian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82431af1b146735da1d6d95450df27c4
https://pubmed.ncbi.nlm.nih.gov/33127424

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REVERSE phenotyping-Can the phenotype following constitutive Tph2 gene inactivation in mice be transferred to children and adolescents with and without adhd?

Publikováno v: Brain and Behavior. 11(5)

Introduction: Experimental models of neuropsychiatric disorders, for example, ADHD, are used to mimic specific phenotypic traits of a complex human disorder. However, it remains unresolved to what extent the animal phenotype reflects the specific hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::ac99113a3860390a4814b2b999a2c9e9
https://doi.org/10.1002/brb3.2054

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Akademický článek

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Akademický článek

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Prenatal stress and subsequent exposure to chronic mild stress in rats; interdependent effects on emotional behavior and the serotonergic system

Autor: Nicole Leibold, Koen Schruers, M. Martinez-Claros, D.L.A. van den Hove, Klaus-Peter Lesch, Jos Prickaerts, Eveline Strackx, Harry W.M. Steinbusch

Publikováno v: European Neuropsychopharmacology, 24(4), 595-607. Elsevier

Exposure to prenatal stress (PS) can predispose individuals to the development of psychopathology later in life. We examined the effects of unpredictable chronic mild stress (CMS) exposure during adolescence on a background of PS in male and female S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b0450287301cb1aca4c42ca2a62586
https://cris.maastrichtuniversity.nl/en/publications/0d9487b5-b9d8-4eb9-b7b6-7718b0e03df4

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