Výsledky vyhledávání - "TRXR, thioredoxin reductase"

Thioredoxin reductase: An emerging pharmacologic target for radiosensitization of cancer

Autor: Raghavendra S. Patwardhan, Deepak Sharma, Santosh K. Sandur

Publikováno v: Translational Oncology, Vol 17, Iss, Pp 101341-(2022)
Translational Oncology

Highlights • Thioredoxin reductase (TrxR), a seleno enzyme, regulates cellular redox. • Several human cancers are known to overexpress TrxR. • Inhibitors of TrxR have enhanced radiation induced cytotoxicity in multiple cancers. • TrxR could b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aaf62bdf3583fc4416746fca6cdfb01
http://www.sciencedirect.com/science/article/pii/S1936523322000031

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Corrigendum to ‘Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity’ [Redox Biol. 14 (2018) 237–249]

Autor: Huihui Zeng, Yuxi Liu, Hanwei Yin, Xiaoqing Zheng, Weiwei Ma, Wei Xu, Ruoxuan Sun, Fei Lin

Publikováno v: Redox Biology, Vol 32, Iss, Pp-(2020)
Redox Biology

Hepatocellular carcinoma (HCC) accounts for most of primary liver cancer, of which five-year survival rate remains low and chemoprevention has become a strategy to reduce disease burden of HCC. We aim to explore the in vivo chemopreventive effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80eb373f3f3770341d44824dda53c2b3
http://www.sciencedirect.com/science/article/pii/S2213231720304936

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Hepatic cell sheets engineered from human mesenchymal stem cells with a single small molecule compound IC-2 ameliorate acute liver injury in mice

Autor: Kaori Okinaka, Goshi Shiota, Hiroyuki Oka, Tsuyoshi Yokobata, Shizuma Okazaki, Ikuya Noda, Minoru Morimoto, Noriko Itaba, Yohei Kono

Publikováno v: Regenerative Therapy, Vol 9, Iss, Pp 45-57 (2018)
Regenerative Therapy

Introduction We previously reported that transplantation of hepatic cell sheets from human bone marrow-derived mesenchymal stem cells (BM-MSCs) with hexachlorophene, a Wnt/β-catenin signaling inhibitor, ameliorated acute liver injury. In a further p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d56c4d56ae22c9ffa2f008940c3783
http://www.sciencedirect.com/science/article/pii/S2352320418300142

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Effects of feeding pregnant beef cows selenium-enriched alfalfa hay on passive transfer of ovalbumin in their newborn calves

Autor: Gene J. Pirelli, Gerd Bobe, William R. Vorachek, Jean A. Hall, K. Denise Apperson, Brian P. Dolan

Publikováno v: Journal of Trace Elements in Medicine and Biology

Intestinal absorption of immunoglobulins is critical for health and survival of newborn calves because there is no transfer of immunoglobulins in utero. The objective of this study was to determine if feeding beef cows Se-enriched alfalfa hay during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8b2db0f4ee77e022bf093543dd6b6f
https://doi.org/10.1016/j.jtemb.2018.05.014

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Redox regulation by reversible protein S-thiolation in Gram-positive bacteria

Autor: Marcel Imber, Agnieszka J. Pietrzyk-Brzezinska, Haike Antelmann

Publikováno v: Redox Biology
Redox Biology, Vol 20, Iss, Pp 130-145 (2019)

Low molecular weight (LMW) thiols play an important role as thiol-cofactors for many enzymes and are crucial to maintain the reduced state of the cytoplasm. Most Gram-negative bacteria utilize glutathione (GSH) as major LMW thiol. However, in Gram-po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f489c6dc700b786fd74ac141fe7a87
http://europepmc.org/articles/PMC6178380

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Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes

Autor: Shanlin Fu, Luke Carroll, Clare L. Hawkins, David I. Pattison, Michael J. Davies, Carl H. Schiesser

Publikováno v: Redox Biology, Vol 12, Iss, Pp 872-882 (2017)
Carroll, L, Pattison, D I, Fu, S, Schiesser, C H, Davies, M J & Hawkins, C L 2017, ' Catalytic oxidant scavenging by selenium-containing compounds : Reduction of selenoxides and N-chloramines by thiols and redox enzymes ', Redox Biology, vol. 12, pp. 872-882 . https://doi.org/10.1016/j.redox.2017.04.023
Redox Biology

Myeloperoxidase produces strong oxidants during the immune response to destroy invading pathogens. However, these oxidants can also cause tissue damage, which contributes to the development of numerous inflammatory diseases. Selenium containing compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5e5218fd8874c2ffff8165ab4d70e2
http://www.sciencedirect.com/science/article/pii/S2213231717302136

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Non-linear impact of glutathione depletion on C. elegans life span and stress resistance

Autor: Michael Ristow, Katrin Erler, Vanessa Stein, Dimitrios Tsitsipatis, Katrin Kreuzer, Nadine Urban, Lars-Oliver Klotz, Holger Steinbrenner, Franziska Hausig

Publikováno v: Redox Biology, Vol 11, Iss, Pp 502-515 (2017)
Redox Biology, 11
Redox Biology

The redox environment in cells and organisms is set by low-molecular mass and protein-bound thiols, with glutathione (GSH) representing a major intracellular redox buffer. Subtle thiol oxidation elicits signal transduction processes and adaptive resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3d0f5a81c28796cc1effeb8046a536
https://doi.org/10.1016/j.redox.2016.12.003

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Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

Autor: Hyejin Jang, Daiha Shin, Jong-Lyel Roh, Eun Hye Kim

Publikováno v: Redox Biology, Vol 11, Iss, Pp 254-262 (2017)
Redox Biology
REDOX BIOLOGY(11)

Artesunate, an anti-malarial drug, has been repurposed as an anticancer drug due to its induction of cell death via reactive oxygen species (ROS) production. However, the molecular mechanisms regulating cancer cell death and the resistance of cells t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65a5ee84666c1b2e71bee510cc6398f
https://doi.org/10.1016/j.redox.2016.12.010

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Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone

Autor: Nan Shu, Qing Cheng, Elias S.J. Arnér, Michael J. Davies

Publikováno v: Shu, N, Cheng, Q, Arner, E S J & Davies, M J 2020, ' Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone ', Redox Biology, vol. 28, 101335 . https://doi.org/10.1016/j.redox.2019.101335
Redox Biology
Redox Biology, Vol 28, Iss, Pp-(2020)

Quinones are common in nature, and often cytotoxic. Their proposed toxicity mechanisms involve redox cycling with radical generation, and/or reactions with nucleophiles, such as protein cysteine (Cys) residues, forming adducts via Michael addition re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deff0ff237c1dbe23349174a540bc470
https://curis.ku.dk/portal/da/publications/inhibition-and-crosslinking-of-the-selenoprotein-thioredoxin-reductase1-by-pbenzoquinone(eca1d1e1-ad99-41d7-8ae2-ef2076fe9b7e).html

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gRASping the redox lever to modulate cancer cell fate signaling

Autor: Chuan Han Jonathan Foo, Shazib Pervaiz

Publikováno v: Redox Biology, Vol 25, Iss, Pp-(2019)
Redox Biology

RAS proteins are critical regulators of signaling networks controlling diverse cellular functions such as cell proliferation and survival and its mutation are among the most powerful oncogenic drivers in human cancers. Despite intense efforts, direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11cd3c78529b5f4eae7369f41a3e411
http://www.sciencedirect.com/science/article/pii/S2213231718311558

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