Zobrazeno 1 - 10
of 699
pro vyhledávání: '"TRPM4"'
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-4 (2024)
Abstract TRPM4 is a non-selective cation channel activated by intracellular Ca2+ but only permeable to monovalent cations, its activation regulates membrane potential and intracellular calcium. This channel participates in the migration and adhesion
Externí odkaz:
https://doaj.org/article/3f2c6afdef1e48a6999d4bdc957a0b60
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
TRPM4 is a calcium activated non-selective cation channel, impermeable to Ca2+, in neurons it has been implicated in the regulation of the excitability and in the persistent firing. Cholinergic stimulation is also implicated in changes in excitabilit
Externí odkaz:
https://doaj.org/article/b97ebc942cb74cf08aa2d9eebde9c12d
Autor:
Zhan Gao, Jing Lv, Ting-Ting Tong, Kai Zhang, Yu-Xuan Han, Yu Zhao, Mei-Mei Shen, Yang Liu, Tao Ban, Yu Sun
Publikováno v:
PeerJ, Vol 12, p e17559 (2024)
Background To investigate the effects of arsenic trioxide (ATO) on human colorectal cancer cells (HCT116) growth and the role of transient receptor potential melastatin 4 (TRPM4) channel in this process. Methods The viability of HCT116 cells was asse
Externí odkaz:
https://doaj.org/article/85466df57f11457dbb05692efee327c3
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e31871- (2024)
Background: Transient receptor potential melastatin 4 (TRPM4) affects immune responses by regulating calcium homeostasis, but its role in calcific aortic valve inflammation remains unclear. This study aimed to assess the expression and function of TR
Externí odkaz:
https://doaj.org/article/c53e198d94f64ef1880248245f287642
Autor:
Charlene P. Poore, Nurul A.M.N. Hazalin, Shunhui Wei, See Wee Low, Bo Chen, Bernd Nilius, Zurina Hassan, Ping Liao
Publikováno v:
Neurobiology of Disease, Vol 191, Iss , Pp 106408- (2024)
Excitotoxicity arises from unusually excessive activation of excitatory amino acid receptors such as glutamate receptors. Following an energy crisis, excitotoxicity is a major cause for neuronal death in neurological disorders. Many glutamate antagon
Externí odkaz:
https://doaj.org/article/0afdc4161e954daa850a94231c7a4c52
Akademický článek
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Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6875 (2024)
Enhanced electrical activity in detrusor smooth muscle (DSM) cells is a key factor in detrusor overactivity which causes overactive bladder pathological disorders. Transient receptor potential melastatin-4 (TRPM4) channels, which are calcium-activate
Externí odkaz:
https://doaj.org/article/5c21630989ab4c4e8763385c7c8202f5
Autor:
Yadong Xue, Tingting Tong, Yuyao Zhang, Haijun Huang, Ling Zhao, Hongzhao Lv, Lingzhao Xiong, Kai Zhang, Yuxuan Han, Yuyang Fu, Yongzhen Wang, Rong Huo, Ning Wang, Tao Ban
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Background: Vascular endothelial injury is a contributing factor to the development of atherosclerosis and the resulting cardiovascular diseases. One particular factor involved in endothelial cell apoptosis and atherosclerosis is palmitic acid (PA),
Externí odkaz:
https://doaj.org/article/eae598952d024f3c844bc1b2add31e2f
Autor:
Laura Mundrucz, Angéla Kecskés, Nóra Henn-Mike, Péter Kóbor, Péter Buzás, Rudi Vennekens, Miklós Kecskés
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Mossy cells comprise a large fraction of excitatory neurons in the hippocampal dentate gyrus, and their loss is one of the major hallmarks of temporal lobe epilepsy (TLE). The vulnerability of mossy cells in TLE is well known in a
Externí odkaz:
https://doaj.org/article/2fa58a8e8bb1442582ab107ed173e007